Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

The molecular biology of apoptosis.

1996 • 963 citations

Regulators of cell death

1995 • 647 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

The Role of Calcium in the Regulation of Apoptosis

1997 • 460 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

1997 • 280 citations

A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro

1997 • 237 citations

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1996 • 164 citations

Chapter 31 Egg Extracts for Nuclear Import and Nuclear Assembly Reactions

1991 • 143 citations

Techniques in apoptosis: A user's guide

1997 • 134 citations

Relationships between DNA Fragmentation, Chromatin Condensation, and Changes in Flow Cytometry Profiles Detected during Apoptosis

1995 • 99 citations

Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

1994 • 98 citations

Apoptosis: lessons from in vitro systems

1995 • 87 citations

Calcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1 and DNA Fragmentation in Isolated Thymocyte Nuclei

1996 • 65 citations

Existence of an inactive pool of acetylcholinesterase in chicken brain.

1993 • 47 citations

Role of proteases in activation of apoptosis

1997 • 30 citations