Role of Calpain‐ and Interleukin‐1β Converting Enzyme‐Like Proteases in the β‐Amyloid‐Induced Death of Rat Hippocampal Neurons in Culture

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Nuclear changes in apoptosis

1995 • 538 citations

Interfering with Apoptosis: Ca ²⁺ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

1996 • 481 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Calcium and Excitotoxic Neuronal Injury

1994 • 351 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Disease^a

1994 • 254 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

Induction of CPP32-like Activity in PC12 Cells by Withdrawal of Trophic Support

1996 • 146 citations

Apoptotic cell death induced by intracellular proteolysis.

1994 • 124 citations

The Ca²⁺ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

1995 • 123 citations

Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons

1995 • 91 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

A phospholipase C inhibitor ameliorates postischemic neuronal damage in rats.

1992 • 30 citations