Induction ofHSP70 gene expression by modulation of Ca+2 ion and cellular p53 protein by curcumin in colorectal carcinoma cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs

1974 • 1,189 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent

1973 • 681 citations

Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

1994 • 550 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation.

1991 • 429 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.

1991 • 381 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Perspectives on mammalian cell death

1988 • 334 citations

Induction of thermotolerance and enhanced heat shock protein synthesis in chinese hamster fibroblasts by sodium arsenite and by ethanol

1983 • 306 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

1993 • 252 citations

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1995 • 242 citations

Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin

1993 • 228 citations

THE BIOLOGY OF CELL DEATH IN TUMOURS

1973 • 222 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

Perspectives on mammalian cell death.

1987 • 183 citations

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression

1987 • 179 citations

Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: A study using electron microscopy and DNA gel electrophoresis

1991 • 162 citations

DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells.

1990 • 143 citations

Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

1995 • 137 citations

Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation

1992 • 134 citations

Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.

1994 • 133 citations

Induction ofp53 andp21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells

1996 • 130 citations

Calcium/magnesium-dependent endonuclease from human spleen: Purification, properties, and role in apoptosis

1993 • 123 citations

Polypeptide Synthesis in Simian Virus 5-Infected Cells

1977 • 116 citations

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.

1992 • 113 citations

The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock

1988 • 109 citations

Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NJH3T3 cells

1994 • 82 citations

Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis

1993 • 65 citations

Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice.

1992 • 64 citations

Rapid turnover of endogenous endonuclease activity in thymocytes: Effects of inhibitors of macromolecular synthesis

1990 • 60 citations

Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relations to AIDS

1988 • 55 citations

Dual control of heat shock response: involvement of a constitutive heat shock element-binding factor.

1993 • 49 citations

The Retinoblastoma Gene Product Is Bound in the Nucleus in Early G1 Phase

1993 • 45 citations

Alterations in protein kinase C type III-α during heat shock of rat embryo fibroblasts

1991 • 25 citations

Receptor‐Effector Coupling

1991 • 8 citations