Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases.

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

1989 • 580 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Apoptosis in pressure overload-induced heart hypertrophy in the rat.

1996 • 416 citations

Programmed Myocyte Cell Death Affects the Viable Myocardium after Infarction in Rats

1996 • 340 citations

Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

1996 • 335 citations

Calcium‐dependent proteases: an enzyme system active at cellular membranes?

1987 • 308 citations

Role of the calpain system in muscle growth

1992 • 297 citations

Calpain inhibition: an overview of its therapeutic potential

1994 • 280 citations

[4] Estimation of biomass in growing cell lines by adenosine triphosphate assay

1986 • 234 citations

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

1996 • 233 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

[15] cAMP analog antagonists of cAMP action

1988 • 184 citations

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1995 • 170 citations

Calpain II Involvement in Mitosis

1988 • 163 citations

Intrinsic Myofilament Alterations Underlying the Decreased Contractility of Stunned Myocardium

1996 • 158 citations

Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA

1994 • 158 citations

Calcium channels and calcium channel antagonists

1987 • 141 citations

Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?

1993 • 135 citations

Calpain as a novel target for treating acute neurodegenerative disorders

1995 • 122 citations

Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle

1993 • 103 citations

Role of Calcium-Activated Neutral Protease (Calpain) in Cell Death in Cultured Neonatal Rat Cardiomyocytes During Metabolic Inhibition

1995 • 98 citations

[2] Extraction of adenosine triphosphate from microbial and somatic cells

1986 • 94 citations

Response of isolated rat heart cells to hypoxia, re-oxygenation, and acidosis.

1981 • 91 citations

Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid.

1985 • 90 citations

Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1

1997 • 89 citations

Inhomogeneous Disappearance of Myofilament-Related Cytoskeletal Proteins in Stunned Myocardium of Guinea Pig

1996 • 89 citations

An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes

1990 • 79 citations

Active recombinant rat calpain II. Bacterially produced large and small subunits associate both in vivo and in vitro.

1994 • 72 citations

Elevated DNase I Levels in Human Idiopathic Dilated Cardiomyopathy: an Indicator of Apoptosis ?

1996 • 63 citations

Apoptosis and pleomorphic micromitochondriosis in the sinus nodes surgically excised from five patients with the long QT syndrome.

1993 • 62 citations

Tandemly Reiterated Negative Enhancer-like Elements Regulate Transcription of a Human Gene for the Large Subunit of Calcium-dependent Protease

1989 • 60 citations

Cardiomyocyte Troponin T Immunoreactivity Is Modified by Cross-linking Resulting From Intracellular Calcium Overload

1996 • 56 citations

Effects of Thiol Protease Inhibitors on Fodrin Degradation During Hypoxia in Cultured Myocytes

1993 • 50 citations

Calpain Translocation during Muscle Fiber Necrosis and Regeneration in Dystrophin-Deficient Mice

1996 • 43 citations

Analysis of Events Associated with Serum Deprivation-Induced Apoptosis in C3H/Sol8 Muscle Satellite Cells

1996 • 43 citations

A selective Ca2+calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells

1991 • 35 citations

Catalase and hydrogen peroxide cytotoxicity in cultured cardiac myocytes

1995 • 28 citations

KT5926 selectively inhibits nerve growth factor-dependent neurite elongation

1994 • 17 citations

Changes in shape and viability of cultured adult rabbit cardiac myocytes during ischemia/reperfusion injury.

1994 • 12 citations