Comparison between the effects of the microsomal Ca2+-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

‘Quanta’ Ca²⁺ release and the control of Ca²⁺ entry by inositol phosphates ‐ a possible mechanism

1990 • 743 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

1989 • 520 citations

A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells

1988 • 344 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

Receptor-mediated calcium entry in fura-2-loaded human platelets stimulated with ADP and thrombin. Dual-wavelengths studies with Mn2+

1989 • 248 citations

Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells

1990 • 207 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.

1990 • 147 citations

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover.

1990 • 144 citations

Calcium mediates the interconversion between two states of the liver inositol 1,4,5-trisphosphate receptor.

1990 • 127 citations

Ca²⁺ influx in human T lymphocytes is induced independently of inositol phosphate production by mobilization of intracellular Ca²⁺ stores. A study with the Ca²⁺ endoplasmic reticulum‐ATPase inhibitor thapsigargin

1990 • 106 citations

The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

1987 • 103 citations

Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

1990 • 90 citations

Ca2+ transients and Mn2+ entry in human neutrophils induced by thapsigargin

1989 • 80 citations

Ca2+-Mobilizing Hormones Stimulate Ca2+ Efflux from Hepatocytes

1989 • 63 citations

Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relations to AIDS

1988 • 55 citations

Ca2+ entry in T cells is activated by emptying the inositol 1,4,5-trisphosphate sensitive Ca2+ pool

1990 • 33 citations