Elevated Intracellular Calcium Blocks Programmed Neuronal Death

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.

1987 • 1,290 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

1960 • 651 citations

Death and the cell

1986 • 616 citations

Calcium regulation of the neuronal growth cone

1988 • 581 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

The signal for capacitative calcium entry

1993 • 423 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1976 • 311 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

Sustained increase in intracellular calcium promotes neuronal survival

1991 • 213 citations

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

1980 • 210 citations

Advances in pharmacology

1999 • 209 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

1992 • 157 citations

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro

1987 • 156 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

NGF and the Treatment of Alzheimer's Disease

1993 • 140 citations

Neuronal Ca2+ signalling takes the local route

1992 • 127 citations

The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival

1989 • 127 citations

Potassium concentration and number of neurons in cultures of dissociated ganglia

1970 • 124 citations

Effects of high K+ concentrations on the growth and development of ciliary ganglion neurons in cell culture

1981 • 116 citations

Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins. Detection, partial purification, and characterization in PC12 cells.

1990 • 116 citations

Elevated potassium induces morphological differentiation of dorsal root ganglionic neurons in dissociated cell culture

1980 • 105 citations

Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity

1993 • 103 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

Long-term regulation of neuronal calcium currents by prolonged changes of membrane potential

1992 • 96 citations

Alterations in the fine structure of nucleoli in sympathetic neurons following NGF-antiserum treatment

1969 • 66 citations

Excess K⁺ and Phorbol Ester Activate Protein Kinase C and Support the Survival of Chick Sympathetic Neurons in Culture

1988 • 58 citations

Suppression of programmed neuronal death by a thapsigargin‐induced Ca²⁺ influx

1995 • 58 citations

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons.

1990 • 53 citations

Fibroblast Growth Factors, Depolarization, and Substratum Interact in a Combinatorial Way to Promote Neuronal Survival

1993 • 38 citations

Suppression of thein vitro andin vivo cytotoxic effects of guanethidine in sympathetic neurons by nerve growth factor

1974 • 38 citations

Imaging Preterminal Calcium Concentration Microdomains in the Squid Gaint Synapse

1991 • 15 citations