Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological Therapy

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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The Biology of Vascular Endothelial Growth Factor

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CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

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Viral Hepatitis and Liver Disease

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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

T-Cell Function and Migration — Two Sides of the Same Coin

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Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Manual of Clinical Laboratory Immunology

1992 • 1,243 citations

Control of apoptosis by Rel/NF-κB transcription factors

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The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

High-Dose Interferon Alfa-2b Significantly Prolongs Relapse-Free and Overall Survival Compared With the GM2-KLH/QS-21 Vaccine in Patients With Resected Stage IIB-III Melanoma: Results of Intergroup Trial E1694/S9512/C509801

2001 • 905 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Important Advances in Oncology

1991 • 768 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

High-fidelity mRNA amplification for gene profiling

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Rapid Effector Function in CD8+ Memory T Cells

1997 • 652 citations

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

1996 • 650 citations

Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

1998 • 576 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

2001 • 535 citations

Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells.

1998 • 524 citations

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

1994 • 522 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

1998 • 505 citations

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals

1999 • 497 citations

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

1998 • 440 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1

1998 • 400 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection

2001 • 374 citations

Mechanisms of interleukin‐10‐mediated immune suppression

2001 • 368 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

2000 • 363 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Use of overlapping peptide mixtures as antigens for cytokine flow cytometry

2001 • 358 citations

High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer.

1997 • 347 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity

1998 • 338 citations

NF- κ B and the innate immune response

2000 • 332 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive.

2000 • 314 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

Real‐time reverse transcriptase–polymerase chain reaction (RT–PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I

2001 • 306 citations

A phase I trial of a recombinant vaccinia virus expressing prostate-specific antigen in advanced prostate cancer.

2000 • 300 citations

T-cell epitope mapping by flow cytometry

1998 • 295 citations

Target Structures of the CD8⁺-T-Cell Response to Human Cytomegalovirus: the 72-Kilodalton Major Immediate-Early Protein Revisited

1999 • 291 citations

Increased Vaccine-Specific T Cell Frequency After Peptide-Based Vaccination Correlates with Increased Susceptibility to In Vitro Stimulation But Does Not Lead to Tumor Regression

1999 • 290 citations

Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry

1998 • 285 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 282 citations

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

2000 • 281 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Maintenance of Large Numbers of Virus-Specific CD8+ T Cells in HIV-Infected Progressors and Long-Term Nonprogressors

2000 • 271 citations

Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides

2000 • 269 citations

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients.

2001 • 258 citations

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

1999 • 257 citations

T cell clonal anergy

1997 • 257 citations

Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptidesin vivo: Implications for tumor vaccines with melanoma-associated antigens

1996 • 250 citations

T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function

1999 • 248 citations

Effects of Interleukin-12 on the Immune Response to a Multipeptide Vaccine for Resected Metastatic Melanoma

2001 • 243 citations

Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection

1998 • 238 citations

Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood

1998 • 234 citations

Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma

2000 • 232 citations

Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.

1987 • 227 citations

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

1999 • 227 citations

The anatomy of T-cell activation and tolerance.

1996 • 225 citations

Phase I trial of a melanoma vaccine with gp100(280-288) peptide and tetanus helper peptide in adjuvant: immunologic and clinical outcomes.

2001 • 223 citations

Phase I trial of a MART-1 peptide vaccine with incomplete Freund's adjuvant for resected high-risk melanoma.

1999 • 223 citations

Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma.

1996 • 216 citations

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin‐10

1997 • 210 citations

Functional Analysis of Antigen-Specific T Lymphocytes by Serial Measurement of Gene Expression in Peripheral Blood Mononuclear Cells and Tumor Specimens

1999 • 206 citations

Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule

2000 • 205 citations

Normal Human CD4+ Memory T Cells Display Broad Heterogeneity in Their Activation Threshold for Cytokine Synthesis

1998 • 202 citations

Death the Fas way: regulation and pathophysiology of CD95 and its ligand

2000 • 201 citations

Frequencies of Memory T Cells Specific for Varicella‐Zoster Virus, Herpes Simplex Virus, and Cytomegalovirus by Intracellular Detection of Cytokine Expression

2000 • 200 citations

Specificity of CTL Interactions with Peptide-MHC Class I Tetrameric Complexes Is Temperature Dependent

1999 • 197 citations

An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (Ctl)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific Ctls but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions

1999 • 197 citations

Control of SIV Rebound Through Structured Treatment Interruptions During Early Infection

2000 • 192 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 189 citations

The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype

1997 • 182 citations

Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35).

1996 • 182 citations

Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor α in response to HLA-A2.1-binding melanoma and viral peptide antigens

1996 • 179 citations

A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia.

1999 • 177 citations

Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity

2000 • 174 citations

Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-10

2001 • 173 citations

The influence of granulocyte macrophage colony-stimulating factor and prior chemotherapy on the immunological response to a vaccine (ALVAC-CEA B7.1) in patients with metastatic carcinoma.

2001 • 173 citations

Dysfunctional Epstein-Barr virus (EBV)–specific CD8+T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

2001 • 169 citations

Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.

1996 • 169 citations

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.

1999 • 167 citations

Assays for monitoring cellular immune responses to active immunotherapy of cancer.

2001 • 167 citations

Signaling defects in T lymphocytes of patients with malignancy

1999 • 166 citations

Negative Selection during the Peripheral Immune Response to Antigen

2000 • 165 citations

Clinical and Immune Responses in Resected Colon Cancer Patients Treated With Anti-Idiotype Monoclonal Antibody Vaccine That Mimics the Carcinoembryonic Antigen

1999 • 163 citations

Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving polyvalent melanoma cell vaccine.

1998 • 162 citations

The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

1996 • 161 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 161 citations

Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience

1999 • 161 citations

Putative Immunodominant Human Immunodeficiency Virus-Specific CD8⁺T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

2000 • 156 citations

Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile

1998 • 154 citations

Requirements for the Maintenance of Th1 Immunity In Vivo Following DNA Vaccination: A Potential Immunoregulatory Role for CD8+ T Cells

2000 • 150 citations

Lipid Vesicle Size Determines the Th1 or Th2 Response to Entrapped Antigen

1998 • 150 citations

Direct enumeration ofBorrelia-reactive CD4 T cellsex vivoby using MHC class II tetramers

2000 • 149 citations

Quantification of Human Cytomegalovirus DNA by Real-Time PCR

2001 • 147 citations

Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma.

1998 • 147 citations

Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo

1999 • 146 citations

Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity

2000 • 146 citations

Optimization of whole blood antigen-specific cytokine assays for CD4+ T cells

2000 • 145 citations

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma.

1999 • 145 citations

Quantitative Analysis of Cytomegalovirus Load Using a Real-Time PCR Assay

2001 • 143 citations

Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells.

1994 • 142 citations

The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor α spots in response to peptide antigens

1997 • 142 citations

Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue

1998 • 141 citations

Inhibition of Activated/Memory (CD45RO+) T Cells by Oxidative Stress Associated with Block of NF-κB Activation

2001 • 140 citations

Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer.

2000 • 139 citations

T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors.

1997 • 139 citations

Quantitation of antigen-reactive T cells in peripheral blood by IFNγ-ELISPOT assay and chromium-release assay: a four-centre comparative trial

2000 • 135 citations

Anti-Tyrosinase-Related Protein-2 Immune Response in Vitiligo Patients and Melanoma Patients Receiving Active-Specific Immunotherapy

1998 • 134 citations

Human melanoma cells do not express Fas (Apo-1/CD95) ligand.

1999 • 133 citations

Evaluation of the interferon-γ ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood

1997 • 133 citations

Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells

1992 • 132 citations

Mechanisms Responsible for Signaling and Functional Defects

1998 • 132 citations

Phase 2 Trial of Vaccination With Tyrosinase Peptides and Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Metastatic Melanoma

2000 • 131 citations

Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.

1990 • 130 citations

Generation of PSA-reactive effector cells after vaccination with a PSA-based vaccine in patients with prostate cancer

2000 • 127 citations

Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection

1998 • 126 citations

HLA-DQ Tetramers Identify Epitope-Specific T Cells in Peripheral Blood of Herpes Simplex Virus Type 2-Infected Individuals: Direct Detection of Immunodominant Antigen-Responsive Cells

2000 • 126 citations

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition

1999 • 126 citations

CD4+CD8dim T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens

2001 • 125 citations

Renal cell carcinoma–derived gangliosides suppress nuclear factor-κB activation in T cells

1999 • 124 citations

A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients.

1997 • 124 citations

Caspase-mediated degradation of T-cell receptor zeta-chain.

1999 • 118 citations

Prolonged Exposure of T Cells to TNF Down-Regulates TCRζ and Expression of the TCR/CD3 Complex at the Cell Surface

2001 • 118 citations

Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth

1995 • 117 citations

The role of Fas/FasL in immunosuppression induced by human tumors

1998 • 115 citations

Evaluation of peptide vaccine immunogenicity in draining lymph nodes and peripheral blood of melanoma patients

2001 • 114 citations

Loss of Cytomegalovirus‐Specific CD4⁺T Cell Responses in Human Immunodeficiency Virus Type 1–Infected Patients with High CD4⁺T Cell Counts and Recurrent Retinitis

2001 • 113 citations

Immunization of patients with melanoma peptide vaccines: immunologic assessment using the ELISPOT assay.

1998 • 112 citations

A T Cell Clone’s Avidity Is a Function of Its Activation State

2001 • 112 citations

Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity.

2002 • 110 citations

Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma.

2000 • 110 citations

Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity

2000 • 107 citations

Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients

1999 • 107 citations

Evaluation of CD8+ T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide

2000 • 107 citations

Contribution of serotype-specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae

1999 • 104 citations

Use of fluorogenic histocompatibility leukocyte antigen-A*0201/HPV 16 E7 peptide complexes to isolate rare human cytotoxic T-lymphocyte-recognizing endogenous human papillomavirus antigens.

2000 • 104 citations

Real-Time Quantitative Polymerase Chain Reaction Assessment of Immune Reactivity in Melanoma Patients After Tumor Peptide Vaccination

2000 • 104 citations

Limiting dilution analysis of virus-specific memory B cells by an ELISPOT assay

1996 • 103 citations

Cytomegalovirus (CMV) DNA Load in Plasma for the Diagnosis of CMV Disease before Engraftment in Hematopoietic Stem‐Cell Transplant Recipients

2001 • 102 citations

Evaluation of the Modified ELISPOT Assay for Gamma Interferon Production in Cancer Patients Receiving Antitumor Vaccines

2000 • 101 citations

Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1.

2001 • 101 citations

Rapid Determination of Epstein-Barr Virus–Specific CD8+T-Cell Frequencies by Flow Cytometry

1999 • 100 citations

Direct Measurement of CD4+ and CD8+ T-Cell Responses to CMV in HIV-1-Infected Subjects

2001 • 96 citations

Clonotypic Structure of the Human CD4+ Memory T Cell Response to Cytomegalovirus

2001 • 93 citations

Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events

2000 • 92 citations

Factors Affecting the Efficiency of CD8+ T Cell Cross-Priming with Exogenous Antigens

2001 • 92 citations

Rapid quantitation of proinflammatory and chemoattractant cytokine expression in small tissue samples and monocyte-derived dendritic cells: validation of a new real-time RT-PCR technology

2000 • 91 citations

Short-Term Kinetics of Tumor Antigen Expression in Response to Vaccination

2001 • 90 citations

Brefeldin A, but not monensin, completely blocks CD69 expression on mouse lymphocytes:

1999 • 90 citations

True

2000 • 90 citations

Assessing Cd8 T Cell Number and Dysfunction in the Presence of Antigen

2001 • 87 citations

Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life

2001 • 86 citations

Critical Role for CD8 in Binding of MHC Tetramers to TCR: CD8 Antibodies Block Specific Binding of Human Tumor- Specific MHC-Peptide Tetramers to TCR

2001 • 86 citations

Alterations in NF B Activation in T Lymphocytes of Patients With Renal Cell Carcinoma

1999 • 83 citations

Gamma Interferon Expression in CD8⁺T Cells Is a Marker for Circulating Cytotoxic T Lymphocytes That Recognize an HLA A2-Restricted Epitope of Human Cytomegalovirus Phosphoprotein pp65

2001 • 82 citations

Induction of MAGE-3 expression in lung and esophageal cancer cells

2001 • 81 citations

The use of a rapid ELISPOT assay to analyze peptide-specific immune responses in carcinoma patients to peptide vs. recombinant poxvirus vaccines

2000 • 79 citations

IgM Anti-Ganglioside Antibodies Induced by Melanoma Cell Vaccine Correlate with Survival of Melanoma Patients

1999 • 79 citations

Flow cytometric determination of intracellular or secreted IFNγ for the quantification of antigen reactive T cells

2001 • 77 citations

EXPRESSION AND FUNCTIONAL ANALYSIS OF CHEMOKINE RECEPTORS IN HUMAN PERIPHERAL BLOOD LEUKOCYTE POPULATIONS

2001 • 75 citations

Application of the IFN-γ ELISPOT assay to quantify T cell responses against proteins

2001 • 74 citations

Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma.

2001 • 70 citations

Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset

2001 • 70 citations

A natural history of melanoma: serial gene expression analysis

2000 • 69 citations

Dendritic Cell/Peptide Cancer Vaccines: Clinical Responsiveness and Epitope Spreading

2000 • 69 citations

Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8⁺T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation

2001 • 68 citations

Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women

1998 • 67 citations

Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen

2001 • 67 citations

IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response

1999 • 66 citations

Stimulation of CD8+ T cell responses to MAGE-3 and Melan A/MART-1 by immunization to a polyvalent melanoma vaccine

1997 • 65 citations

Antigenic Response to Booster Dose of Diphtheria and Tetanus Toxoids: Seven to Thirteen Years after Primary Inoculation of Noninstitutionalized Children

1962 • 63 citations

Flow cytometric measurement of intracellular cytokines detects immune responses in MUC1 immunotherapy.

2000 • 62 citations

CD3ζ and CD28 down-modulation on CD8 T cells during viral infection

2000 • 61 citations

Unique T Cell Effector Functions Elicited by Plasmodium falciparum Epitopes in Malaria-Exposed Africans Tested by Three T Cell Assays

2001 • 59 citations

Elevated caspase-3 activity in peripheral blood T cells coexists with increased degree of T-cell apoptosis and down-regulation of TCR zeta molecules in patients with gastric cancer.

2001 • 59 citations

In vivo tracking of tumor-specific T cells

2001 • 59 citations

A rapid real-time quantitative polymerase chain reaction for hepatitis B virus

2001 • 59 citations

Immune response to polyvalent melanoma cell vaccine in AJCC stage III melanoma: An immunologic survival model

1996 • 59 citations

Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization

2001 • 58 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells.

2001 • 55 citations

Cytomegalovirus (CMV)–Specific CD4⁺T Lymphocyte Immune Function in Long‐Term Survivors of AIDS‐Related CMV End‐Organ Disease Who Are Receiving Potent Antiretroviral Therapy

2001 • 55 citations

Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness

2001 • 55 citations

Transient expansion of peptide-specific lymphocytes producing IFN-gamma after vaccination with dendritic cells pulsed with MAGE peptides in patients with mage-A1/A3-positive tumors.

2001 • 55 citations

Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients

2001 • 53 citations

Competition of peptide-MHC class I tetrameric complexes with anti-CD3 provides evidence for specificity of peptide binding to the TCR complex

2000 • 52 citations

High frequencies of circulating melanoma-reactive CD8+ T cells in patients with advanced melanoma

2000 • 51 citations

Immunofluorescence analysis of T-cell responses in health and disease.

2000 • 49 citations

Direct Functional Analysis of Epitope-Specific CD8⁺T Cells in Peripheral Blood

2001 • 49 citations

Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules

1998 • 49 citations

A comparison between ELISPOT methods for the detection of cytokine producing cells: greater sensitivity and specificity using ELISA plates as compared to nitrocellulose membranes

1997 • 48 citations

Differential Effect of Human Immunodeficiency Virus Infection on the IgA and IgG Antibody Responses to Pneumococcal Vaccine

1995 • 48 citations

Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics

2001 • 48 citations

Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression.

2001 • 45 citations

New insights into T-cell antigen receptor structure and signal transduction

1992 • 45 citations

Melanoma vaccines: the paradox of T cell activation without clinical response

2000 • 45 citations

Enhancement of HIV Type 1 Antigen-Specific CD4⁺T Cell Memory in Subjects with Chronic HIV Type 1 Infection Receiving an HIV Type 1 Immunogen

2000 • 43 citations

Mechanisms of Tumor-Induced Immunosuppression: Evidence for Contact-Dependent T Cell Suppression by Monocytes

1996 • 43 citations

Transient expansion of peptide-specific lymphocytes producing IFN-γ after vaccination with dendritic cells pulsed with MAGE peptides in patients with mage-A1/A3-positive tumors

2001 • 40 citations

Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules

1998 • 39 citations

Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice.

2000 • 39 citations

Rapid quantification of SIV-specific CD8 T cell responses with recombinant vaccinia virus ELISPOT or cytokine flow cytometry

2000 • 38 citations

Method for quantitation of IgG subclass antibodies in mouse serum by enzyme-linked immunosorbent assay

1995 • 38 citations

Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients.

2000 • 37 citations

Ehrlich tumor stimulates extramedullar hematopoiesis in mice without secreting identifiable colony-stimulating factors and without engagement of host T cells

1999 • 36 citations

A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity

1995 • 35 citations

Alterations in Signal Transduction in T Cells from Cancer Patients

1995 • 35 citations

Expression of CD3-ζ on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes

1999 • 34 citations

Measurement of Anti-Human Cytomegalovirus T Cell Reactivity in Transplant Recipients and Its Potential Clinical Use: A Mini-Review

1999 • 33 citations

Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay

2001 • 33 citations

Quantitative Monitoring of Circulating Epstein-Barr Virus DNA for Predicting the Development of Posttransplantation Lymphoproliferative Disease

2001 • 32 citations

Detection and quantification of CD8+ T cells specific for HLA-A*0201-binding melanoma and viral peptides by the IFN-?-elispot assay

2001 • 32 citations

Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy

2000 • 32 citations

Detection of CD4 T-cell responses to a tumor vaccine by cytokine flow cytometry.

2001 • 31 citations

Application of IL-5 ELISPOT assays to quantification of antigen-specific T helper responses

2002 • 31 citations

Tumor cells regulate the lytic activity of tumor-specific cytotoxic t lymphocytes by modulating the inhibitory natural killer receptor function.

2001 • 30 citations

Human Prostate Cancer Blocks the Generation of Dendritic Cells from CD34+ Hematopoietic Progenitors

2001 • 30 citations

Expression of Signal-Transducing Zeta Chain in Peripheral Blood T Cells and Natural Killer Cells in Patients with Hodgkin's Disease in Different Phases of the Disease

1999 • 29 citations

Restoration of expression of signal-transduction molecules in lymphocytes from patients with metastatic renal cell cancer after combination immunotherapy

1999 • 28 citations

Renal cell carcinoma : molecular biology, immunology, and clinical management

2000 • 27 citations

Insect cells as HLA-restricted antigen-presenting cells for the IFN-γ Elispot assay

2000 • 24 citations

cDNA arrays and the enigma of melanoma immune responsiveness.

2001 • 24 citations

Application of the Intracellular Gamma Interferon Assay To Recalculate the Potency of CD8⁺T-Cell Responses to Herpes Simplex Virus

2000 • 24 citations

An assessment of the immunological status of patients with renal cell carcinoma based on the relative abundance of T‐helper 1‐ and ‐2 cytokine‐producing CD4⁺ cells in peripheral blood

2001 • 23 citations

A longitudinal study of in vitro IFNγ production and cytotoxic T cell responses of tuberculosis patients in The Gambia

2000 • 23 citations

Computer-Assisted, Quantitative Cytokine Enzyme-Linked Immunospot Analysis of Human Immune Effector Cell Function

1997 • 22 citations

TGF-?-based immunotherapy for cancer: Breaching the tumor firewall

2000 • 22 citations

PBLs of Early Breast Carcinoma Patients with a High Nuclear Grade Tumor Unlike PBLs of Cervical Carcinoma Patients Do Not Show a Decreased TCRξ Expression but Are Functionally Impaired

1998 • 21 citations

Regulation of Activator Protein-1 and NF-κB in CD8+ T Cells Exposed To Peripheral Self-Antigens

2001 • 21 citations

Monitoring Specific T-Cell Responses to Melanoma Vaccines: ELISPOT, Tetramers, and Beyond

2000 • 21 citations

Immunological Effects of BCG as an Adjuvant in Autologous Tumor Vaccines

2000 • 20 citations

Cellular immunotherapy for patients with metastatic colorectal carcinoma using lymph node lymphocytes localized in vivo by radiolabeled monoclonal antibody

1999 • 18 citations

Molecular Mechanisms of Immune Dysfunction in Renal Cell Carcinoma

2000 • 18 citations

Application of quantitative RT-PCR using "TaqMan" technology to evaluate the expression of CK 18 mRNA in various cell lines.

2000 • 15 citations

High frequency of circulating HBcAg-specific CD8 T cells in hepatitis B infection: a flow cytometric analysis

2001 • 12 citations

Direct detection of cellular immune responses to cancer vaccines

2001 • 11 citations

Characterization of tumor vaccines during product development

2000 • 9 citations

Detection of Mycobacterium‐specific interferon‐gamma‐producing human T lymphocytes by flow cytometry

2000 • 9 citations

Immunology and immunotherapy of melanoma

1993 • 9 citations

Combination vaccines : development, clinical research, and approval

1999 • 7 citations

Diagnostic and Therapeutic Immunology of Renal Cell Cancer

1979 • 6 citations

Immunological Correlates for Efficacy of Combination Vaccines

1999 • 5 citations