Renal cell carcinoma–derived gangliosides suppress nuclear factor-κB activation in T cells
Data up to Jan 2025
Total Citations Per Year
Abstract
References (54)
NF-κB: Ten Years After
1996 • 3,008 citations
Quantitive estimation of sialic acids
1957 • 2,782 citations
Signal transduction through NF-κB
1998 • 1,103 citations
Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.
1996 • 985 citations
Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.
1990 • 889 citations
Biosynthesis and Function of Gangliosides
1976 • 748 citations
Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice
1992 • 650 citations
Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link
1990 • 517 citations
Functional Role of Glycosphingolipids in Cell Recognition and Signaling
1995 • 393 citations
Impaired in Vitro Lymphocyte Transformation in Hodgkin's Disease
1965 • 379 citations
Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity
1996 • 364 citations
Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.
1986 • 319 citations
Human interleukin-10 can directly inhibit T-cell growth
1993 • 283 citations
Modulation of T-cell function by gliomas
1991 • 241 citations
A solvent partition method for microscale ganglioside purification
1985 • 175 citations
The Suppressor-Cell Network in Cancer
1978 • 172 citations
Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.
1994 • 166 citations
T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.
1993 • 158 citations
Mechanisms of apoptosis in T cells from patients with renal cell carcinoma.
1999 • 145 citations
Expression of transforming growth factor alpha in normal human adult kidney and enhanced expression of transforming growth factors alpha and beta 1 in renal cell carcinoma.
1989 • 143 citations
Human interleukin-10 can directly inhibit T-cell growth
1993 • 143 citations
[23] Thin-layer chromatography of glycosphingolipids
1994 • 139 citations
Lack of interleukin‐2 (IL‐2) expression and selective expression of IL‐10 mRNA in human renal cell carcinoma
1995 • 129 citations
Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.
1992 • 117 citations
Ceramide structure predicts tumor gangliosideimmunosuppressive activity.
1994 • 110 citations
Characterization of a Human Renal Cell Carcinoma Specific Cytotoxic CD8+ T Cell Line
1992 • 100 citations
Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells.
1996 • 98 citations
Preferential clonogenic deficit of CD8-positive T-lymphocytes infiltrating human solid tumors.
1988 • 95 citations
Selective cytokine gene expression in renal cell carcinoma tumor cells and tumor‐infiltrating lymphocytes
1995 • 93 citations
T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.
1994 • 84 citations
Alterations in NF B Activation in T Lymphocytes of Patients With Renal Cell Carcinoma
1999 • 83 citations
Ganglioside GM3 inhibition of EGF receptor mediated signal transduction
1996 • 83 citations
IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes.
1996 • 80 citations
Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line.
1994 • 79 citations
Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.
1998 • 77 citations
An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage.
1993 • 71 citations
Human tumor gangliosides inhibit murine immune responses in vivo.
1995 • 70 citations
Natural forms of shed tumor gangliosides
1998 • 68 citations
Disialosyl galactosylgloboside as an adhesion molecule expressed on renal cell carcinoma and its relationship to metastatic potential.
1996 • 65 citations
Gangliosides block antigen presentation by human monocytes
1996 • 65 citations
Gangliosides suppress tumor necrosis factor production in human monocytes.
1992 • 64 citations
Impaired Activation of NFκB in T Cells From a Subset of Renal Cell Carcinoma Patients Is Mediated by Inhibition of Phosphorylation and Degradation of the Inhibitor, IκB
1998 • 59 citations
Changes in glycolipids in human renal‐cell carcinoma and their clinical significance
1991 • 55 citations
Relationship of Glycosyltransferases and mRNA Levels to Ganglioside Expression in Neuroblastoma and Melanoma Cells
1999 • 47 citations
T cell immune response to cancer in humans and its relevance for immunodiagnosis and therapy.
1992 • 43 citations
Expression of Globo‐series Gangliosides in Human Renal Cell Carcinoma
1997 • 43 citations
Aberrant Expression of Gangliosides in Human Renal Cell Carcinomas
1993 • 42 citations
Modulation of a Ca2+ signaling pathway by GM1 ganglioside in PC12 cells.
1992 • 39 citations
Abrogation of shedding of immunosuppressive neuroblastoma gangliosides.
1996 • 30 citations
Distinctive glycolipid patterns in Wilms' tumor and renal cell carcinoma
1991 • 23 citations
Brain-derived gangliosides induce cell cycle arrest in a murine T cell line
1998 • 21 citations
Inhibition of immune cell proliferation and cytokine production by lipoprotein-bound gangliosides
1994 • 21 citations
Gangliosides and antitumor immunity
1993 • 20 citations
Sphingolipid-Dependent Protein Kinases
1996 • 13 citations