Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

1993 • 827 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

1981 • 566 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia [see comments]

1995 • 379 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.

1987 • 227 citations

Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma.

1995 • 218 citations

Defined Flanking Spacers and Enhanced Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine

2001 • 178 citations

Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16‐induced tumors

1995 • 168 citations

A mouse mutant p53 product recognized by CD4+ and CD8+ T cells.

1994 • 168 citations

In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

1999 • 157 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

T Cell Recognition of Human Tumors: Implications for Molecular Immunotherapy of Cancer

1993 • 137 citations

Immunosuppressive Factors in Human Cancer

1992 • 131 citations

Myeloid differentiation treatment to diminish the presence of immune-suppressive CD34+ cells within human head and neck squamous cell carcinomas.

1997 • 86 citations

Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells.

1993 • 85 citations

Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.

1994 • 82 citations

Involvement of nitric oxide in bone marrow-derived natural suppressor activity. Its dependence on IFN-gamma.

1995 • 80 citations

Genetic Immunotherapy of Established Tumors with Adenovirus-Murine Granulocyte-Macrophage Colony-Stimulating Factor

1997 • 79 citations

Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses.

1995 • 63 citations

Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction

1999 • 56 citations

Direct effects of 13-cis and all-trans retinoic acid on normal bone marrow (BM) progenitors: Comparative study on BM mononuclear cells and on isolated CD 34+ BM cells

1993 • 46 citations

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

1981 • 40 citations

IL-12 and Mutant P53 Peptide-Pulsed Dendritic Cells for the Specific Immunotherapy of Cancer

1996 • 39 citations

Detection of leukemic clone maturation in vivo by premature chromosome condensation

1988 • 29 citations

ALL-TransRetinoic Acid and Hematopoietic Growth Factors Regulating the Growth and Differentiation of Blast Progenitors in Acute Promyelocytic Leukemia

1999 • 18 citations

Modulation of Growth Factor Receptors on Acute Myeloblastic Leukemia Cells by Retinoic Acid

1994 • 9 citations

Detection of leukemic clone maturation in vivo by premature chromosome condensation

1988 • 4 citations