The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

1989 • 487 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

B7, a B-cell-restricted antigen that identifies preactivated B cells.

1987 • 211 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 205 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

Association of p62, a Multifunctional SH2- and SH3-Domain-Binding Protein, with src Family Tyrosine Kinases, Grb2, and Phospholipase Cγ-1

1995 • 198 citations

Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail

1995 • 189 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells.

1994 • 174 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.

1992 • 172 citations

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.

1994 • 169 citations

p21ras mediates control of IL-2 gene promoter function in T cell activation.

1992 • 166 citations

B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct.

1996 • 165 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules.

1995 • 162 citations

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.

1995 • 161 citations

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21^ras

1995 • 155 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

1989 • 143 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.

1993 • 134 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 133 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.

1996 • 123 citations

Role of B7-1 in mediating an immune response to myeloid leukemia cells

1995 • 122 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

Expression of functional B7 and CTLA4 on rheumatoid synovial T cells.

1994 • 103 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 101 citations

Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.

1993 • 99 citations

p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.

1993 • 91 citations

Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.

1996 • 85 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

1995 • 80 citations

Signal Transduction by CD28 Costimulatory Receptor on T Cells

1996 • 77 citations

Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2).

1996 • 77 citations

Defective TCR-mediated signaling in anergic T cells.

1995 • 70 citations

B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation.

1993 • 70 citations

Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

1993 • 66 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

Sphingomyelin‐ceramide turnover in CD28 costimulatory signaling

1995 • 66 citations

Altered protein tyrosine phosphorylation in anergic Th1 cells.

1993 • 65 citations

CD28 costimulation up-regulates long-term IL-2R beta expression in human T cells through combined transcriptional and post-transcriptional regulation.

1995 • 61 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

IL-1 alpha is produced by T lymphocytes activated via the CD2 plus CD28 pathways.

1991 • 53 citations

IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor

1995 • 51 citations

Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin

1995 • 48 citations

Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation.

1991 • 47 citations

Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model.

1994 • 45 citations

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

1993 • 44 citations

Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes.

1994 • 39 citations

Fas Antigen and Sphingomyelin‐Ceramide Turnover‐Mediated Signaling: Role in Life and Death of T Lymphocytes¹

1994 • 37 citations

Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.

1992 • 37 citations

Regulation of interleukin‐4 production in human mononuclear cells

1992 • 35 citations

Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating factor (CSF-1) gene.

1992 • 16 citations