Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Specificity of CTL Interactions with Peptide-MHC Class I Tetrameric Complexes Is Temperature Dependent

1999 • 197 citations

Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.

2000 • 192 citations

Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.

1997 • 176 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

1995 • 106 citations

Correlation Between the Number of T Cell Receptors Required for T Cell Activation and TCR–Ligand Affinity

1996 • 103 citations

Interleukin-2-induced, melanoma-specific T cells recognize camel, an unexpected translation product ofLAGE-1

1999 • 103 citations

Peptide-MHC Class I Tetrameric Complexes Display Exquisite Ligand Specificity

2000 • 96 citations

Association of CD8 with p56lck is required for early T cell signalling events.

1991 • 79 citations

Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.

1999 • 71 citations

T cell positive selection by a high density, low affinity ligand

1998 • 69 citations

Effects of Epitope Modification on T Cell Receptor–Ligand Binding and Antigen Recognition by Seven H-2Kd–restricted Cytotoxic T Lymphocyte Clones Specific for a Photoreactive Peptide Derivative

1997 • 51 citations

The cysteine residues in the cytoplasmic tail of CD8 α are required for its coreceptor function

1993 • 20 citations