Expression of Signal-Transducing Zeta Chain in Peripheral Blood T Cells and Natural Killer Cells in Patients with Hodgkin's Disease in Different Phases of the Disease

Clinical Cancer Research

1941 • 1,358 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Epstein-Barr Virus (EBV)-Specific Cytotoxic T Lymphocytes for the Treatment of Patients With EBV-Positive Relapsed Hodgkin's Disease

1998 • 295 citations

Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

1995 • 217 citations

Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma.

1996 • 216 citations

Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites.

1996 • 215 citations

Journal of the National Cancer Institute

1969 • 199 citations

Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.

1990 • 169 citations

Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.

1996 • 169 citations

Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.

1995 • 150 citations

Lymphocyte abnormalities in untreated patients with Hodgkin's disease

1976 • 124 citations

Impaired delayed-hypersensitivity responses in 154 patients with untreated Hodgkin's disease.

1973 • 117 citations

Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy.

1996 • 111 citations

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

1996 • 99 citations

T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

1996 • 93 citations

Homologous and Heterologous Skin Transplantation in Patients With Lymphomatous Disease

1961 • 86 citations

T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

1996 • 71 citations

Comparison of multiple in vivo and in vitro parameters in untreated patients with Hodgkin's disease

1976 • 70 citations

Variable expression of CD3‐zeta and associated protein tyrosine kinases in lymphocytes from patients with myeloid malignancies

1998 • 64 citations

Monoclonal antibodies reactive with the T cell receptor zeta chain: production and characterization using a new method.

1989 • 60 citations

High Frequency of Cancer Patients with Abnormal Assembly of the T Cell Receptor‐CD3 Complex in Peripheral Blood T Lymphocytes

1994 • 52 citations

TCR ζ chain in T cell development and selection

1997 • 51 citations

Assembly, intracellular processing, and expression at the cell surface of the human alpha beta T cell receptor/CD3 complex. Function of the CD3-zeta chain.

1989 • 47 citations

T cell immune response to cancer in humans and its relevance for immunodiagnosis and therapy.

1992 • 43 citations

Demonstration of cytoplasmic and nuclear antigens in acute leukaemia using flow cytometry.

1994 • 38 citations

Natural killer cell activity during the course of disease in patients with Hodgkin's disease

1985 • 36 citations

National Cancer Institute Monograph 28

1968 • 35 citations

Correlation between disease activity and T‐cell CD3 chain expression in a B‐cell lymphoma

1994 • 33 citations

DISTRIBUTION OF T‐CELL SIGNALLING MOLECULES IN HUMAN MYELOMA

1997 • 23 citations

Immunologic profile in patients with Hodgkin's disease in complete remission

1987 • 18 citations

Tumor-Induced Suppression of Antitumor Reactivity and Depression of TCRζ Expression in Tumor-Draining Lymph Node Lymphocytes: Possible Relationship to the Th2 Pathway

1997 • 15 citations

Impairment in proliferation, lymphokine production and frequency distribution of mitogen-responsive and interleukin-2-producing cells in Hodgkin's disease

1991 • 11 citations

Expression and Signal Transduction of T‐Cell Antigen Receptor (TCR)/CD3 Complexes on Fresh or In Vitro Expanded T Lymphocytes from Patients with Hodgkin's and Non‐Hodgkin's Lymphomas

1997 • 8 citations

Decreased production of interferon gamma by anti‐CD3 monoclonal antibody and interleukin‐2 ‐stimulated peripheral blood mononuclear cells in Hodgkin's disease

1995 • 5 citations