Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

A New Look at T Cells

1998 • 269 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

LIGAND RECOGNITION BY T CELL RECEPTORS

1998 • 207 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics

1999 • 194 citations

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands

1997 • 183 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

1997 • 169 citations

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

1990 • 136 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

1998 • 117 citations

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain

1994 • 115 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

1996 • 99 citations

Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events

1992 • 94 citations

CD8β Increases CD8 Coreceptor Function and Participation in TCR–Ligand Binding

1996 • 93 citations

Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro.

1996 • 87 citations

An immunological role for the CD8 β-chain

1992 • 76 citations

Signal extinction and T cell repolarization in T helper cell‐antigen‐presenting cell conjugates

1996 • 76 citations

A role for the cytoplasmic tail of the β chain of CD8 in thymic selection

1994 • 70 citations

Resting and activated T cells display different requirements for CD8 molecules.

1994 • 64 citations

The p56^lck SH2 domain mediates recruitment of CD8/p56^lck to the activated T cell receptor/CD3/ζ complex

1996 • 62 citations

Evidence for CD8-independent T cell maturation in transgenic mice.

1990 • 53 citations

Cutting Edge: A Test of the Dominant Negative Signal Model for TCR Antagonism

1999 • 46 citations

Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck

1998 • 39 citations

Distinct Functions of CD8(CD4) are Utilized at Different Stages of T‐Lymphocyte Differentiation

1989 • 35 citations

Affinity enhancement and transmembrane signaling are associated with distinct epitopes on the CD8 alpha beta heterodimer.

1991 • 18 citations

CD8 and antigen-specific T cell adhesion cascades

1993 • 5 citations