Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

1996 • 650 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.

1993 • 386 citations

Revisiting and revising suppressor T cells

1992 • 256 citations

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

1991 • 201 citations

Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression

1996 • 194 citations

Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.

1996 • 125 citations

Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis.

1993 • 102 citations

Predominance of a type 2 intratumoural immune response in fresh tumour-infiltrating lymphocytes from human gliomas

1996 • 86 citations

IMMUNOLOGIC DYSFUNCTION IN CANCER

1996 • 78 citations

Comparison of multiple in vivo and in vitro parameters in untreated patients with Hodgkin's disease

1976 • 70 citations

Specific and non-specific lymphocyte cytotoxicity in colon carcinoma

1981 • 70 citations

Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture

1996 • 67 citations

Intradermal administration of lipopolysaccharide in treatment of human cancer

1996 • 65 citations

Impact of Hodgkin's disease upon the immune system.

1980 • 62 citations

Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes.

1989 • 49 citations

Displacement of T Lymphocytes with the ‘Helper/Inducer’ Phenotype from Peripheral Blood to Lymphoid Organs in Untreated Patients with Hodgkin's Disease

1983 • 43 citations

Impaired production of tumor necrosis factor in breast cancer

1990 • 28 citations

Does antibody-dependent epitope masking permit progressive tumour growth in the face of cell-mediated cytotoxicity?

1991 • 25 citations

In vitro assessment of immunocompetence in patients with malignant melanoma

1977 • 22 citations

Tumor necrosis factor.

1987 • 19 citations

T lymphocyte subsets in patients with malignant melanoma

1981 • 17 citations

An analysis of skin tests and their relationship to recurrence and survival in stage III and stage IV melanoma patients

1982 • 9 citations

Myelopoietic abnormalities in patients with metastatic carcinoma

1978 • 6 citations

A case report of recurrent cervical cancer which responded to a combination of biological therapies.

1994 • 5 citations

The Prognostic Significance of Recall Antigen Testing in Melanoma Patients

1987 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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