Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin‐10

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Interleukin-10

1993 • 1,820 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

1996 • 1,105 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.

1995 • 756 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.

1997 • 443 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells

1995 • 282 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor

1997 • 244 citations

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

1994 • 205 citations

IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells.

1995 • 194 citations

Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression.

1995 • 162 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Dendritic cells hold promise for immunotherapy

1997 • 135 citations

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.

1996 • 47 citations

CD40 engagement induces monocyte procoagulant activity through an interleukin‐10 resistant pathway

1996 • 38 citations