Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin-10

1993 • 1,820 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Pancreatic Carcinoma

1992 • 1,175 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

1993 • 628 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia.

1992 • 376 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1994 • 335 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Human non-small cell lung cancer cells express a type 2 cytokine pattern

1996 • 263 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

The role of IL-10 in human B cell activation, proliferation, and differentiation.

1995 • 241 citations

Regulation of NK cell functions by TGF-beta 1.

1995 • 241 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor

1995 • 207 citations

Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

1995 • 203 citations

Local expression of antiinflammatory cytokines in cancer.

1993 • 198 citations

Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression

1996 • 194 citations

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

1992 • 181 citations

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.

1995 • 180 citations

Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes

1991 • 176 citations

Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production.

1996 • 160 citations

Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression.

1990 • 159 citations

Antimetastatic and Antitumor Activities of Interleukin 10 in a Murine Model of Breast Cancer

1996 • 157 citations

Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.

1991 • 151 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Immunosuppressive Factors in Human Cancer

1992 • 131 citations

An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

1994 • 130 citations

Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells.

1994 • 124 citations

The glioblastoma‐derived t cell suppressor factor/ transforming growth factor‐β2 inhibits t cell growth without affecting the interaction of interleukin 2 with its receptor

1988 • 123 citations

Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells.

1988 • 117 citations

Further studies of the role of transforming growth factor-beta in human B cell function.

1989 • 108 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

TGFβ₁ and TGFβ₂ are potential growth regulators for low‐grade and malignant gliomas in vitro: Evidence in support of an autocrine hypothesis

1991 • 107 citations

Murine immune response to cells transfected with human MUC1: immunization with cellular and synthetic antigens.

1994 • 79 citations

Expression of cytokine mRNA in human melanoma tissues

1995 • 73 citations

Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-β1

1997 • 70 citations

Factors, including transforming growth factor β, released in the glioblastoma residual cavity, impair activity of adherent lymphokine-activated killer cells

1993 • 64 citations

Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines.

1996 • 63 citations

Co-stimulation of T cell proliferation by transforming growth factor-beta 1.

1991 • 62 citations

Evidence That TGF-β Can Inhibit Human T-Lymphocyte Proliferation through Paracrine and Autocrine Mechanisms

1993 • 60 citations

Production of Cytokines by Human Melanoma Cells and Melanocytes

1995 • 38 citations

Immunoregulatory effects of transforming growth factor-β in a prolonged period of culture

1992 • 11 citations

Simultaneous detection of cytokine and immunophenotype at the single cell level by immunoenzymatic double staining

1996 • 8 citations

Induction and Regulation of CD4 ⁺ T Cell Subsets

2007 • 5 citations