Lipid Vesicle Size Determines the Th1 or Th2 Response to Entrapped Antigen

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose

1984 • 1,697 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

AN EXTENSION OF THE51Cr-RELEASE ASSAY FOR THE ESTIMATION OF MOUSE CYTOTOXINS

1968 • 707 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Professional and non-professional phagocytes: an introduction

1995 • 521 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

1994 • 383 citations

Towards a comprehensive view of immunoglobulin class switching

1993 • 373 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Role of Contractile Microfilaments in Macrophage Movement and Endocytosis

1971 • 353 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Immunology of Leishmaniasis

1993 • 337 citations

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

1995 • 300 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production.

1997 • 265 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Role of interleukin 1 in the activation of T lymphocytes.

1988 • 231 citations

In interleukin‐4‐deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production

1996 • 230 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1971 • 230 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion technique

1989 • 193 citations

Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation.

1991 • 164 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells.

1995 • 150 citations

The immune response to Plasmodium chabaudi malaria in interleukin‐4‐deficient mice

1994 • 138 citations

The adjuvant activity of non-ionic surfactant vesicles (niosomes) on the BALB/c humoral response to bovine serum albumin.

1992 • 123 citations

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo.

1993 • 98 citations

Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles.

1992 • 93 citations

Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS

1995 • 88 citations

Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors.

1989 • 85 citations

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.

1996 • 84 citations

In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation.

1995 • 79 citations

Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens.

1993 • 77 citations

Post-formation fluorescent labelling of liposomal membranes

1992 • 62 citations

Congenital toxoplasmosis in the Balb/c mouse: prevention of vertical disease transmission and fetal death by vaccination

1994 • 53 citations

Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization.

1984 • 52 citations

The demonstration of an essential role for macrophages in the in vivo generation of IgG2a antibodies

1994 • 43 citations

Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis.

1991 • 30 citations

Distinct antigen presenting cell-derived signals induce T_H cell proliferation and expression of effector cytokines

1992 • 29 citations

Histologic analysis of T lymphocyte activation in reactive lymph nodes.

1991 • 24 citations

Accurate determination of adjuvant-associated protein or peptide by ninhydrin assay

1995 • 23 citations

Rapid establishment of a stable IL-4/IFN-γ production profile in the antigen-specific CD4⁺ T cell response to protein immunization

1994 • 21 citations

Immunodetection of recombinant proteins based on antibodies directed against a metal binding peptide engineered for purification by immobilized metal affinity chromatography

1992 • 12 citations

Trichuris update '93

1993 • 7 citations

Differentiation of V beta 8.2+ CD4+ T cells induced by a superantigen: roles of antigen-presenting cells and cytokines.

1994 • 5 citations