Multiple roles for MMPs and TIMPs in cerebral ischemia

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2003 • 4,348 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Tissue inhibitors of metalloproteinases: evolution, structure and function

2000 • 1,873 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain

2000 • 1,218 citations

Metalloproteinase inhibitors: biological actions and therapeutic opportunities

2002 • 1,159 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Matrix metalloproteinases in neuroinflammation

2002 • 830 citations

Role of angiogenesis in patients with cerebral ischemic stroke.

1994 • 820 citations

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

2001 • 677 citations

A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

2003 • 643 citations

Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia

2000 • 641 citations

Matrix metalloproteinases: multifunctional contributors to tumor progression

2000 • 639 citations

Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94

2000 • 593 citations

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

1999 • 548 citations

Matrix Metalloproteinase-9 Pretreatment Level Predicts Intracranial Hemorrhagic Complications After Thrombolysis in Human Stroke

2003 • 534 citations

TIMP-2 Mediated Inhibition of Angiogenesis

2003 • 494 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Cortical spreading depression activates and upregulates MMP-9

2004 • 446 citations

Plasmin and Matrix Metalloproteinases in Vascular Remodeling

2001 • 436 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Cortical spreading depression activates and upregulates MMP-9

2004 • 413 citations

Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

2001 • 382 citations

Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

2001 • 382 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.

2001 • 365 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

Matrix Metalloproteinases in Cerebrovascular Disease

1998 • 353 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Matrix Metalloproteinase Expression After Human Cardioembolic Stroke

2001 • 334 citations

Structural properties of matrix metalloproteinases

1999 • 324 citations

TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix

2000 • 323 citations

Matrix Metalloproteinase Expression Is Related to Hemorrhagic Transformation After Cardioembolic Stroke

2001 • 297 citations

The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family

1995 • 295 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

Hemorrhagic Transformation and Microvascular Integrity during Focal Cerebral Ischemia/Reperfusion

1996 • 291 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

2004 • 271 citations

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

1999 • 268 citations

Neutrophil Infiltration Increases Matrix Metalloproteinase-9 in the Ischemic Brain after Occlusion/Reperfusion of the Middle Cerebral Artery in Rats

2003 • 247 citations

Role of Matrix Metalloproteinases in Delayed Neuronal Damage after Transient Global Cerebral Ischemia

2004 • 239 citations

Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain

2004 • 238 citations

Gelatinase B modulates selective opening of the blood-brain barrier during inflammation

1998 • 233 citations

Matrix Metalloproteinases in Brain Injury

1995 • 228 citations

Cloning of the cDNA Encoding Human Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) and Mapping of the TIMP3 Gene to Chromosome 22

1994 • 214 citations

Regulation of Matrix Metalloproteinase Expression in Astrocytes, Microglia and Neurons

1996 • 211 citations

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

2001 • 211 citations

Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury

2002 • 205 citations

Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium

2000 • 190 citations

Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo

2000 • 187 citations

Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications.

2001 • 187 citations

Exploitation of Astrocytes by Glioma Cells to Facilitate Invasiveness: A Mechanism Involving Matrix Metalloproteinase-2 and the Urokinase-Type Plasminogen Activator–Plasmin Cascade

2003 • 187 citations

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

2003 • 184 citations

Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells.

1990 • 180 citations

Neuronal activity‐dependent increase of net matrix metalloproteinase activity is associated with MMP‐9 neurotoxicity after kainate

2003 • 174 citations

Matrix‐degrading proteases and angiogenesis during development and tumor formation

1999 • 169 citations

Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia

2000 • 159 citations

Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia

2001 • 154 citations

Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke.

1999 • 153 citations

Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

2002 • 149 citations

Fas/CD95/APO‐1 Can Function as a Death Receptor for Neuronal Cells in Vitro and in Vivo and is Upregulated Following Cerebral Hypoxic‐Ischemic Injury to the Developing Rat Brain

2000 • 144 citations

Differential Inhibition of Membrane Type 3 (MT3)-Matrix Metalloproteinase (MMP) and MT1-MMP by Tissue Inhibitor of Metalloproteinase (TIMP)-2 and TIMP-3 Regulates Pro-MMP-2 Activation

2004 • 139 citations

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases

1995 • 135 citations

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

1994 • 135 citations

Activation Systems for Latent Matrix Metalloproteinase-2 are Upregulated Immediately after Focal Cerebral Ischemia

2003 • 133 citations

Essential role for ERK mitogen‐activated protein kinase in matrix metalloproteinase‐9 regulation in rat cortical astrocytes

2003 • 131 citations

Tumor progression: Defining the soil round the tumor seed

2001 • 130 citations

HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors

2001 • 127 citations

Fas Receptor and Neuronal Cell Death after Spinal Cord Ischemia

2000 • 127 citations

Upregulation of the Fas Receptor Death-Inducing Signaling Complex after Traumatic Brain Injury in Mice and Humans

2002 • 126 citations

Matrix Metalloproteinases and Neuroinflammation in Multiple Sclerosis

2002 • 125 citations

Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin

1998 • 124 citations

Jekyll–Hyde neurotrophins: the story of proNGF

2002 • 123 citations

Dynamic Changes in Cerebral Blood Flow and Angiogenesis After Transient Focal Cerebral Ischemia in Rats

2002 • 121 citations

Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro

1999 • 119 citations

Angiogenesis in Ischemic Disease

1999 • 112 citations

Induction of matrix metalloproteinase‐9 (MMP‐9) in lipopolysaccharide‐stimulated primary astrocytes is mediated by extracellular signal‐regulated protein kinase 1/2 (Erk1/2)

2002 • 112 citations

Hemorrhagic Transformation of Cerebral Infarction – Possible Mechanisms

1999 • 109 citations

Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.

2001 • 105 citations

Regulation of tissue inhibitor of metalloproteinase‐1 by astrocytes: Links to HIV‐1 dementia

2003 • 95 citations

Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.

2002 • 90 citations

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

2003 • 89 citations

Tissue inhibitor of metalloproteinases‐3 and matrix metalloproteinase‐3 regulate neuronal sensitivity to doxorubicin‐induced apoptosis

2003 • 88 citations

Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons

2003 • 83 citations

β-Amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes

2003 • 81 citations

Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding

1997 • 76 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

Regulation of Insulin-Like Growth Factor (IGF)-I Action by Matrix Metalloproteinase-3 Involves Selective Disruption of IGF-I/IGF-Binding Protein-3 Complexes

2003 • 66 citations

Matrix metalloproteinase-9 expression in post-hypoxic human brain capillary endothelial cells: H2O2 as a trigger and NF-κB as a signal transducer

2003 • 65 citations

Matrix Metalloproteinase 1 Interacts with Neuronal Integrins and Stimulates Dephosphorylation of Akt

2004 • 65 citations

New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors

1999 • 64 citations

The tight-junction-specific protein ZO-l is a component of the human and rat blood-brain barriers

1991 • 63 citations

Fas-Mediated Apoptosis in Ewing's Sarcoma Cell Lines by Metalloproteinase Inhibitors

1999 • 53 citations

MMPs Are IGFBP‐Degrading Proteinases: Implications for Cell Proliferation and Tissue Growth

1999 • 51 citations

The Rev axis of HIV-1 and its associated host cofactors: A viral window onto the workings of eukaryotic posttranscriptional RNA processing

1996 • 46 citations

Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells

1998 • 45 citations

Tissue Inhibitor of Metalloproteinase-3 is Associated with Neuronal Death in Reperfusion Injury

2002 • 44 citations

Novel Processing of β-Amyloid Precursor Protein Catalyzed by Membrane Type 1 Matrix Metalloproteinase Releases a Fragment Lacking the Inhibitor Domain against Gelatinase A

2003 • 43 citations

Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem cells

1999 • 41 citations

Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia.

2001 • 34 citations

Matrix metalloproteinase‐1 activates a pertussis toxin‐sensitive signaling pathway that stimulates the release of matrix metalloproteinase‐9

2002 • 33 citations

Matrix Metalloproteinases in Neuroinflammation and Cerebral Ischemia

2004 • 33 citations

Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases

2004 • 18 citations