β-Amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

Textbook of Rheumatology

1985 • 1,671 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Matrix metalloproteinases: they're not just for matrix anymore!

2001 • 1,257 citations

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

2001 • 975 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Quantitative Zymography: Detection of Picogram Quantities of Gelatinases

1994 • 866 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Textbook of Rheumatology.

1988 • 593 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.

1992 • 329 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

A central role for astrocytes in the inflammatory response to β-amyloid; chemokines, cytokines and reactive oxygen species are produced

1999 • 313 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates

2000 • 289 citations

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.

1992 • 208 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

Plasminogen activator secretion by granule neurons in cultures of developing cerebellum.

1981 • 188 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Fibronectin profiles in normal and chronic wound fluid.

1990 • 158 citations

Increased Production of Matrix Metalloproteinases in Enriched Astrocyte and Mixed Hippocampal Cultures Treated with β‐Amyloid Peptides

1996 • 153 citations

Fibronectin fragments in osteoarthritic synovial fluid.

1992 • 146 citations

Synergistic Induction of Nitric Oxide by β-Amyloid and Cytokines in Astrocytes

1996 • 134 citations

Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A

1994 • 129 citations

Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain

2000 • 123 citations

Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification

1997 • 117 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

β-Amyloid neurotoxicity: A discussion of in vitro findings

1992 • 113 citations

Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.

1992 • 112 citations

Characterization of Neutral Proteinases from Alzheimer‐Affected and Control Brain Specimens: Identification of Calcium‐Dependent Metalloproteinases from the Hippocampus

1992 • 109 citations

Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease

2000 • 86 citations

White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues

1995 • 78 citations

Release of Biological Activities from Quiescent Fibronectin by a Conformational Change and Limited Proteolysis by Matrix Metalloproteinases

1995 • 76 citations

Localization of Tissue Inhibitor of Matrix Metalloproteinases in Alzheimerʼs Disease and Normal Brain

1995 • 74 citations

Glial hyaluronate-binding protein: a product of metalloproteinase digestion of versican?

1995 • 74 citations

Fibronectin fragments bind to and penetrate cartilage tissue resulting in proteinase expression and cartilage damage

1993 • 68 citations

Stromelysin generates a fibronectin fragment that inhibits Schwann cell proliferation.

1992 • 63 citations

Commentary and perspective on studies of beta amyloid neurotoxicity

1992 • 40 citations

Differential expression of fibronectin, tenascin-C and NCAMs in cultured hippocampal astrocytes activated by kainate, bacterial lipopolysaccharide or basic fibroblast growth factor

1997 • 21 citations

Appearance of localized immunoreactivity for the α4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls

1994 • 16 citations