Regulation of Insulin-Like Growth Factor (IGF)-I Action by Matrix Metalloproteinase-3 Involves Selective Disruption of IGF-I/IGF-Binding Protein-3 Complexes

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

2003 • 4,348 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

The Family of Matrix Metalloproteinases^a

1994 • 437 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Insulin-like growth factor binding protein proteolysis

2003 • 235 citations

Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

1994 • 218 citations

Identification of Insulin-like Growth Factor-binding Protein-1 as a Potential Physiological Substrate for Human Stromelysin-3

1997 • 208 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin.

1996 • 163 citations

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

1995 • 158 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex.

1992 • 141 citations

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases

1995 • 135 citations

Extracellular matrix regulation of growth factor and protease activity

1991 • 128 citations

Complex Roles of Matrix Metalloproteinases in Tumor Progression

1996 • 121 citations

Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1

1999 • 106 citations

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

1994 • 106 citations

The Role of the Tyrosine Kinase Domain of the Insulin-like Growth Factor-I Receptor in Intracellular Signaling, Cellular Proliferation, and Tumorigenesis

1995 • 106 citations

Folding and characterization of the amino‐terminal domain of human tissue inhibitor of metalloproteinases‐1 (TIMP‐1) expressed at high yield in E. coli

1996 • 101 citations

Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

1995 • 100 citations

INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS IN GROWTH

1996 • 97 citations

Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability

2002 • 77 citations

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

1994 • 65 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex

1992 • 64 citations

Aluminum-Induced Mitogenesis in MC3T3-E1 Osteoblasts: Potential Mechanism Underlying Neoosteogenesis*

1991 • 58 citations

Insulinlike Growth Factor-Binding Protein Proteolysis

1997 • 54 citations

Properties of glycosylated and non-glycosylated human recombinant IGF binding protein-3 (IGFBP-3).

1993 • 37 citations

Characterization of the 46-kDa Intermediates of Matrix Metalloproteinase 3 (Stromelysin 1) Obtained by Site-directed Mutation of Phenylalanine 83

1996 • 27 citations