Angiogenesis in Ischemic Disease

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

1998 • 1,239 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Constitutive Expression of phVEGF ₁₆₅ After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

1998 • 1,109 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

VEGF is required for growth and survival in neonatal mice

1999 • 901 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

1996 • 788 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

1998 • 680 citations

Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

1998 • 662 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1998 • 638 citations

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

1994 • 616 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

1998 • 572 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Vascular endothelial growth factor C induces angiogenesis in vivo

1998 • 558 citations

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1998 • 551 citations

Induction of Neoangiogenesis in Ischemic Myocardium by Human Growth Factors

1998 • 541 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

1999 • 501 citations

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

1998 • 496 citations

Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

1999 • 490 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

1997 • 459 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2

1998 • 434 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors

1998 • 418 citations

A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain

1998 • 412 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Direct Intramuscular Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor Augments Collateral Development and Tissue Perfusion

1996 • 396 citations

Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death

1999 • 393 citations

Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border

1998 • 389 citations

Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia

1998 • 379 citations

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

1997 • 368 citations

Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia

1998 • 353 citations

Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor

1991 • 352 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

Angiogenesis in ischemic heart disease

1997 • 322 citations

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

1998 • 320 citations

Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.

1996 • 315 citations

Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats

1997 • 311 citations

Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

1994 • 310 citations

Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia

1998 • 308 citations

Molecular Cloning of a Novel Vascular Endothelial Growth Factor, VEGF-D

1997 • 305 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

Vascular endothelial grouth facter B, a novel growth facter for endothelial cells

1996 • 279 citations

VEGF and flt

1996 • 276 citations

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

1999 • 276 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Vascular endothelial growth factor administration in chronic myocardial ischemia

1996 • 246 citations

Cell Type Specific Upregulation of Vascular Endothelial Growth Factor in an MCA-occlusion Model of Cerebral Infarct

1999 • 240 citations

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

1996 • 239 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and its Receptors (Flt-1 and Flk-1) following Permanent and Transient Occlusion of the Middle Cerebral Artery in the Rat

1998 • 236 citations

Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures

1999 • 234 citations

Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L

1999 • 209 citations

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1998 • 207 citations

Arteriogenesis Versus Angiogenesis: Two Mechanisms of Vessel Growth

1999 • 198 citations

Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity

1998 • 195 citations

Direct Intramuscular Injection of Plasmid DNA Encoding Angiopoietin-1 but not Angiopoietin-2 Augments Revascularization in the Rabbit Ischemic Hindlimb

1998 • 189 citations

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

1999 • 183 citations

Increased brain capillaries in chronic hypoxia

1999 • 182 citations

Hypoxic Regulation of Vascular Endothelial Growth Factor mRNA Stability Requires the Cooperation of Multiple RNA Elements

1999 • 176 citations

Therapeutic Angiogenesis Following Arterial Gene Transfer of Vascular Endothelial Growth Factor in a Rabbit Model of Hindlimb Ischemia

1996 • 170 citations

Cloning and characterization of a novel human gene related to vascular endothelial growth factor.

1996 • 147 citations

VEGF deprivation-induced apoptosis is a component of programmed capillary regression

1999 • 144 citations

血小板由来増殖因子/血管内皮増殖因子ファミリーと相関するc‐fos誘導性遺伝子の同定

1996 • 138 citations

Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion

1998 • 131 citations

Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures

1995 • 125 citations

Nucleotide Sequence, Chromosomal Assignment and mRNA Expression of Mouse Hypoxia-Inducible Factor-1α

1996 • 123 citations

Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat

1998 • 119 citations

VEGF mRNA and Its Receptorflt-1Are Expressed in Reactive Astrocytes Following Neural Grafting and Tumor Cell Implantation in the Adult CNS

1998 • 116 citations

Hypoxia‐induced brain angiogenesis in the adult rat.

1995 • 104 citations

Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain

1999 • 89 citations

The vascular endothelial growth factor mRNA contains an internal ribosome entry site

1998 • 82 citations

Expression of vascular endothelial growth factor mRNA following transient forebrain ischemia in rats

1999 • 76 citations

What, if anything, is an angiogenic factor?

1996 • 70 citations

Angiogenesis and Vasculogenesis in Treatment of Cardiovascular Disease

1998 • 60 citations

Vascular Endothelial Growth Factor-C A Growth Factor for Lymphatic and Blood Vascular Endothelial Cells

1998 • 52 citations

Functions of the VEGF Receptor-1 (FLT-1) in the Vasculature

1998 • 49 citations