Activation Systems for Latent Matrix Metalloproteinase-2 are Upregulated Immediately after Focal Cerebral Ischemia

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94

2000 • 593 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

1999 • 548 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

1999 • 403 citations

Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.

1994 • 391 citations

Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

2001 • 382 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Blood vessel maturation in a 3‐dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness

2001 • 357 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia

1997 • 319 citations

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1997 • 304 citations

Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity.

1996 • 298 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Vascular Endothelial Growth Factor Increases Release of Gelatinase A and Decreases Release of Tissue Inhibitor of Metalloproteinases by Microvascular Endothelial Cellsin Vitro

1998 • 287 citations

Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.

1996 • 278 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Vascular endothelial groth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatininase a activation and cell proliferation

1998 • 274 citations

Cerebral Infarction

1974 • 266 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors

1994 • 223 citations

Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion.

1994 • 207 citations

Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases

1988 • 199 citations

Hypoxia-mediated stimulation of carcinoma cell invasivenessvia upregulation of urokinase receptor expression

1999 • 195 citations

MMP-2: Expression, Activation and Inhibition

1996 • 195 citations

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.

1989 • 182 citations

Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells

1990 • 182 citations

Dual expression of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase in fibrotic human livers

1997 • 178 citations

Experimental acute thrombotic stroke in baboons.

1986 • 178 citations

Proteolysis, Cell Adhesion, Chemotaxis, and Invasiveness Are Regulated by the u-PA-u-PAR-PAI-1 System

1999 • 175 citations

Peptide-Derived Antagonists of the Urokinase Receptor. Affinity Maturation by Combinatorial Chemistry, Identification of Functional Epitopes, and Inhibitory Effect on Cancer Cell Intravasation

2001 • 174 citations

Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases.

1990 • 173 citations

Plasmin activates pro‐matrix metalloproteinase‐2 with a membrane‐type 1 matrix metalloproteinase‐dependent mechanism

2002 • 154 citations

Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

1992 • 151 citations

Activated Microvessels Express Vascular Endothelial Growth Factor and Integrin α_vβ₃ During Focal Cerebral Ischemia

1999 • 148 citations

Rapid Loss of Microvascular Integrin Expression during Focal Brain Ischemia Reflects Neuron Injury

2001 • 141 citations

Microglia isolated from rat brain secrete a urokinase-type plasminogen activator

1992 • 127 citations

Localization of tissue plasminogen activator in the endothelium of a limited number of vessels.

1994 • 125 citations

Matrix Metalloproteinases in the Neocortex and Spinal Cord of Amyotrophic Lateral Sclerosis Patients

1996 • 123 citations

Expression of Three Membrane-type Matrix Metalloproteinases (MT-MMPs) in Rat Vascular Smooth Muscle Cells and Characterization of MT3-MMPs with and without Transmembrane Domain

1997 • 117 citations

Detection of vitronectin mRNA in tissues and cells of the mouse.

1991 • 116 citations

Increased Expression of Membrane-Type Matrix Metalloproteinase and Preferential Localization of Matrix Metalloproteinase-2 to the Neointima of Balloon-Injured Rat Carotid Arteries

1998 • 116 citations

Rapid Differential Endogenous Plasminogen Activator Expression After Acute Middle Cerebral Artery Occlusion

2001 • 110 citations

DNA Scission After Focal Brain Ischemia

1997 • 107 citations

Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation.

1995 • 102 citations

Role and Localization of Urokinase Receptor in the Formation of New Microvascular Structures in Fibrin Matrices

1999 • 97 citations

Transforming growth factor‐βl as a regulator of the serpins/t‐PA axis in cerebral ischemia

1999 • 97 citations

Urokinase‐type Plasminogen Activator Expression by Neurons and Oligodendrocytes During Process Outgrowth in Developing Rat Brain

1993 • 95 citations

Transient Focal Ischemia in Subhuman Primates

1983 • 85 citations

White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues

1995 • 78 citations

Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice

1999 • 73 citations

Histologic assessment of neurons in rat models of cerebral ischemia.

1990 • 72 citations

Stromelysin-1 and gelatinase A are upregulated before TNF-α in LPS-stimulated neuroinflammation

2002 • 70 citations

Modulated expression of plasminogen activator system components in cultured cells from dissociated mouse dorsal root ganglia

1996 • 65 citations

Developmental transition in plasticity properties of differentiating astrocytes: Age‐related biochemical profile of plasminogen activators in astroglial cultures

1990 • 63 citations

Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: An immunohistochemical study

2000 • 59 citations

Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain

1996 • 55 citations

Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinase

1998 • 51 citations

Up-regulation of urokinase-type plasminogen activator and its receptor correlates with enhanced invasion activity of human glioma cells mediated by transforming growth factor-alpha or basic fibroblast growth factor.

2000 • 48 citations

Cell-surface plasminogen activation causes a retraction of in vitro cultured human umbilical vein endothelial cell monolayer

1994 • 47 citations

Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues

1998 • 39 citations

Expression of the activation marker urokinase plasminogen-activator receptor in cultured human central nervous system microglia

1996 • 38 citations

Regulation of plasminogen activators and type‐1 plasminogen activator inhibitor by cyclic AMP and phorbol ester in rat astrocytes

1992 • 34 citations

Expression of Membrane-Type Matrix Metalloproteinase in Rabbit Neointimal Tissue and Its Correlation with Matrix-Metalloproteinase-2 Activation

1998 • 33 citations

Synthesis of Urokinase‐Type Plasminogen Activator and of Type‐ 1 Plasminogen Activator Inhibitor in Neuronal Cultures of Human Fetal Brain: Stimulation by Phorbol Ester

1990 • 32 citations

Urokinase‐type plasminogen activator up‐regulates the expression of its cellular receptor

2000 • 24 citations

Brain Injury and Cerebrovascular Fibrin Deposition Correlate with Reduced Antithrombotic Brain Capillary Functions in a Hypertensive Stroke Model

2000 • 22 citations

Elevation of mRNA levels of tissue-type plasminogen activator and urokinase-type plasminogen activator in hippocampus and cerebral cortex following middle cerebral artery occlusion in rats

2000 • 17 citations

Epitope Mapping of the Anti-Urokinase Monoclonal Antibody 5B4 by Isolated Domains of Urokinase

1989 • 8 citations

Deleted Work

1955 • 0 citations