Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

2002 • 1,755 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Metalloproteinase inhibitors: biological actions and therapeutic opportunities

2002 • 1,159 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

Molecular mechanisms of blood vessel growth

2001 • 999 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention

1999 • 840 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

2001 • 692 citations

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

2002 • 638 citations

Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones

2000 • 589 citations

Tumor targeting with a selective gelatinase inhibitor

1999 • 554 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

2001 • 475 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis

2002 • 434 citations

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

2000 • 389 citations

Generation and degradation of human endostatin proteins by various proteinases

2000 • 379 citations

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

2001 • 327 citations

New Functions for Non-collagenous Domains of Human Collagen Type IV

2000 • 308 citations

Human endothelial gelatinases and angiogenesis

2001 • 294 citations

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

1998 • 274 citations

Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance

1999 • 274 citations

Developmental Control of Blood Cell Migration by the Drosophila VEGF Pathway

2002 • 273 citations

Manipulating Angiogenesis

1997 • 260 citations

Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2

2000 • 249 citations

New functional roles for non-collagenous domains of basement membrane collagens

2002 • 228 citations

The role of collagen-derived proteolytic fragments in angiogenesis

2001 • 199 citations

Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells

1999 • 169 citations

Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen

2001 • 144 citations

Matrix Metalloproteinase-9-Dependent Exposure of a Cryptic Migratory Control Site in Collagen is Required before Retinal Angiogenesis

2002 • 133 citations

Regulation of Vascular Growth and Regression by Matrix Metalloproteinases in the Rat Aorta Model of Angiogenesis

2000 • 126 citations

Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.

1999 • 107 citations

Interaction of endostatin with integrins implicated in angiogenesis

2001 • 84 citations

In VivoNeutrophil Recruitment by Granulocyte Chemotactic Protein-2 Is Assisted by Gelatinase B/MMP-9 in the Mouse

2000 • 75 citations

Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck

2002 • 33 citations