Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

1996 • 601 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

The AP-1 site and MMP gene regulation: What is all the fuss about?

1997 • 507 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.

1996 • 278 citations

Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan

1998 • 271 citations

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

1999 • 268 citations

Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system

1999 • 268 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

1995 • 252 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.

1995 • 238 citations

Membrane-type 1 Matrix Metalloprotease (MT1-MMP) Enables Invasive Migration of Glioma Cells in Central Nervous System White Matter

1999 • 236 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Human Brain Tumors

1998 • 185 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

Attenuation of Astroglial Reactivity by Interleukin-10

1996 • 182 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS

1998 • 179 citations

Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma.

1999 • 174 citations

Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

1997 • 169 citations

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 • 162 citations

Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury

1997 • 159 citations

Increased production of gelatinase B (matrix metalloproteinase‐9) and interleukin‐6 by activated rat microglia in culture

1995 • 154 citations

Astrogliosis in the Neonatal and Adult Murine Brain Post-Trauma: Elevation of Inflammatory Cytokines and the Lack of Requirement for Endogenous Interferon-γ

1997 • 151 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

1998 • 143 citations

Fas Ligand and Fas Are Expressed Constitutively in Human Astrocytes and the Expression Increases with IL-1, IL-6, TNF-α, or IFN-γ

1999 • 142 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Monoclonal antibodies recognize individual neurofilament triplet proteins.

1982 • 121 citations

Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro

1999 • 119 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Interferon‐β Is a Potent Promoter of Nerve Growth Factor Production by Astrocytes

1997 • 91 citations

Co-expression of mRNA for Neurotrophic Factors in Human Neurons and Glial Cells in Culture

1994 • 77 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis and may be associated with vascularization

1995 • 67 citations

Co-localization of interleukin-1 receptor type I and interleukin-1 receptor antagonist with vasopressin in magnocellular neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus

1999 • 46 citations

Oligodendrocyte‐type 2 Astrocyte Progenitors Use a Metalloendoprotease to Spread and Migrate on CNS Myelin

1997 • 41 citations

Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine

1995 • 40 citations

Biphasic transforming growth factor-β production flanking the pro-inflammatory cytokine response in cerebral trauma

1995 • 38 citations

Biphasic transforming growth factor-β production flanking the pro-inflammatory cytokine response in cerebral trauma

1995 • 37 citations

The potential use of MMP inhibitors to treat CNS diseases

1999 • 36 citations

Differential expression of fibroblast growth factor receptors by human neurones, astrocytes, and microglia

1994 • 31 citations

Expression of extracellular matrix degrading enzymes during migration of xenografted brain cells

1999 • 25 citations

Clinical Neuroimmunology

1988 • 20 citations

Purification of cell populations from human fetal brain using flow cytometric techniques

1995 • 17 citations

Response of astrocytes and oligodendrocytes to injury

1998 • 14 citations

Studies on the binding of vitamin B12 by human saliva

1972 • 5 citations

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