Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

1998 • 731 citations

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

1998 • 687 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94

2000 • 593 citations

Generation of Biologically Active IL-1β by Matrix Metalloproteinases: A Novel Caspase-1-Independent Pathway of IL-1β Processing

1998 • 556 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Numerous candidate plasticity-related genes revealed by differential cDNA cloning

1993 • 522 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

1999 • 403 citations

Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

1986 • 380 citations

Degradation of Interleukin 1β by Matrix Metalloproteinases

1996 • 374 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on Morphological and Motor Outcomes after Traumatic Brain Injury

2000 • 362 citations

Matrix Metalloproteinases in Cerebrovascular Disease

1998 • 353 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Membrane‐type matrix metalloproteinases

1999 • 303 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

1999 • 268 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss

1987 • 232 citations

Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2

2000 • 218 citations

Regulation of Matrix Metalloproteinase Expression in Astrocytes, Microglia and Neurons

1996 • 211 citations

A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice

1996 • 200 citations

Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo

2000 • 187 citations

Spatiotemporal Expression Patterns of Metalloproteinases and Their Inhibitors in the Postnatal Developing Rat Cerebellum

1999 • 185 citations

Increased production of gelatinase B (matrix metalloproteinase‐9) and interleukin‐6 by activated rat microglia in culture

1995 • 154 citations

Glial changes following an excitotoxic lesion in the CNS—II. Astrocytes

1991 • 148 citations

The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth.

1996 • 142 citations

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1999 • 141 citations

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Is Differentially Induced in Neurons and Astrocytes after Seizures: Evidence for Developmental, Immediate Early Gene, and Lesion Response

1997 • 137 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Regional and differential expression of gelatinases in rat brain after systemic kainic acid or bicuculline administration

1998 • 112 citations

Metalloproteinase-Dependent Neurite Outgrowth within a Synthetic Extracellular Matrix Is Induced by Nerve Growth Factor

1994 • 111 citations

Evaluation of Some Newer Matrix Metalloproteinases

1999 • 98 citations

Extraction of collagenase from the involuting rat uterus

1976 • 96 citations

Distribution of ischemic neuronal damage in the dorsal hippocampus of rat

1988 • 84 citations

Regulation of Matrix Metalloproteinases and Their Inhibitor Genes in Lipopolysaccharide-Induced Endotoxemia in Mice

2000 • 78 citations

Neuronal Excitation-driven and AP-1-dependent Activation of Tissue Inhibitor of Metalloproteinases-1 Gene Expression in Rodent Hippocampus

1999 • 66 citations

Subtractive Cloning Identifies Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) Increased Gene Expression Following Focal Stroke

1998 • 59 citations

The Rev axis of HIV-1 and its associated host cofactors: A viral window onto the workings of eukaryotic posttranscriptional RNA processing

1996 • 46 citations

Cytokines secreted by glial cells infected with HTLV-I modulate the expression of matrix metalloproteinases (MMPs) and their natural inhibitor (TIMPs): possible involvement in neurodegenerative processes

1997 • 44 citations

Estimation of Gelatinase Content in Rat Brain: Effect of Focal Ischemia

2000 • 38 citations

Models for Gain-of-Function and Loss-of-Function of MMPs: Transgenic and Gene Targeted Mice

2003 • 31 citations

Regulation of gelatinase B (MMP‐9) in leukocytes by plant lectins

1998 • 28 citations

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Neuronal Plasticity and Pathology

1999 • 9 citations