Jekyll–Hyde neurotrophins: the story of proNGF

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system

2000 • 1,053 citations

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

1999 • 797 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

2001 • 538 citations

Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth

1999 • 516 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

1998 • 476 citations

The Precursor Pro-Nerve Growth Factor Is the Predominant Form of Nerve Growth Factor in Brain and Is Increased in Alzheimer's Disease

2001 • 473 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

1999 • 452 citations

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

1999 • 396 citations

p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins

1993 • 359 citations

Neurotrophin Signaling via Trks and p75

1999 • 356 citations

Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

1994 • 319 citations

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1994 • 313 citations

P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors

1998 • 303 citations

Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

2000 • 286 citations

Neurotrophins

2002 • 272 citations

The uniqueness of being a neurotrophin receptor

2001 • 194 citations

p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

1999 • 193 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.

1991 • 148 citations

Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase

2002 • 127 citations

The three-dimensional solution structure and dynamic properties of the human FADD death domain 1 1Edited by A. Fersht

2000 • 96 citations

Pro-sequence assisted folding and disulfide bond formation of human nerve growth factor††Dedicated to Rita Levi-Montalcini.22Edited by R. Huber

2001 • 96 citations

A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor

1999 • 40 citations