HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.

1986 • 1,242 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

Neural mechanisms of learning and memory

1977 • 864 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia

1995 • 663 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Dementia Associated with the Acquired Immunodeficiency Syndrome

1995 • 465 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dememtia

1993 • 418 citations

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

1997 • 403 citations

HIV-1 Protein Tat Induces Apoptosis of Hippocampal Neurons by a Mechanism Involving Caspase Activation, Calcium Overload, and Oxidative Stress

1998 • 400 citations

Transient Exposure to HIV-1 Tat Protein Results in Cytokine Production in Macrophages and Astrocytes

1999 • 351 citations

Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

1996 • 310 citations

Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1

1991 • 305 citations

Human immunodeficiency virus type 1 tat activates non—N‐methyl‐<scp>D</scp>‐aspartate excitatory amino acid receptors and causes neurotoxicity

1995 • 277 citations

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

1999 • 268 citations

Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: Protection by memantine

2000 • 259 citations

Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials

1999 • 234 citations

Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus.

1989 • 233 citations

Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis

1990 • 212 citations

Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes.

1997 • 205 citations

Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia

1999 • 204 citations

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells

1997 • 200 citations

Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8

1999 • 191 citations

Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion

1993 • 186 citations

Neuronal Death Induced by Brain-Derived Human Immunodeficiency Virus Type 1 Envelope Genes Differs between Demented and Nondemented AIDS Patients

1998 • 177 citations

Human Immunodeficiency Virus and the Brain: Investigation of Virus Load and Neuropathologic Changes in Pre-AIDS Subjects

1993 • 153 citations

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

1998 • 143 citations

Glioma invasionin vitro: regulation by matrix metalloprotease-2 and protein kinase C

1996 • 137 citations

Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes

1996 • 127 citations

A model of human immunodeficiency virus encephalitis in scid mice.

1993 • 121 citations

Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro

1999 • 119 citations

Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity

2000 • 97 citations

Presence of Matrix Metalloproteinase‐9 Activity in the Cerebrospinal Fluid of Human Immunodeficiency Virus—Infected Patients

1998 • 97 citations

Cytotoxicity by Matrix Metalloprotease-1 in Organotypic Spinal Cord and Dissociated Neuronal Cultures

2000 • 83 citations

HIV-1 Tat-mediated Inhibition of the Tyrosine Hydroxylase Gene Expression in Dopaminergic Neuronal Cells

2000 • 81 citations

HIV-1 Tat Molecular Diversity and Induction of TNF-α: Implications for HIV-Induced Neurological Disease

1998 • 80 citations

Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat

1995 • 79 citations

Human immunodeficiency virus type-1 Nef protein induces blood–brain barrier disruption in the rat: role of matrix metalloproteinase-9

2000 • 76 citations

Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas

1999 • 73 citations

Neurovirulence in Feline Immunodeficiency Virus-Infected Neonatal Cats Is Viral Strain Specific and Dependent on Systemic Immune Suppression

1998 • 68 citations

Excitotoxic Cell Death Dependent on Inhibitory Receptor Activation

1999 • 65 citations

Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants

1999 • 59 citations

Human immunodeficiency virus‐1‐tat induces matrix metalloproteinase‐9 in monocytes through protein tyrosine phosphatase‐mediated activation of nuclear transcription factor NF‐κB

1999 • 58 citations

Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines

2000 • 51 citations

Feline immunodeficiency virus causes increased glutamate levels and neuronal loss in brain

1997 • 49 citations

Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity

1998 • 48 citations

Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains

1998 • 36 citations

Inhibition of matrix metalloproteinase MMP-2 activates chloride current in human airway epithelial cells

1999 • 36 citations

Increased activity of matrix metalloproteinase-2 in human glial and neuronal cell lines treated with HIV-1 gp41 peptides

1998 • 23 citations

A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro

1999 • 22 citations

Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells

1997 • 14 citations

Antisense Oligodeoxynucleotides Targeting Internal Exon Sequences Efficiently Regulate TNF-α Expression

1999 • 10 citations