Cortical spreading depression activates and upregulates MMP-9

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

2002 • 1,179 citations

Matrix metalloproteinases: a tail of a frog that became a prince

2002 • 1,082 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Migraine as a Risk Factor for Subclinical Brain Lesions

2004 • 935 citations

Matrix metalloproteinases in neuroinflammation

2002 • 830 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94

2000 • 593 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Lipoprotein receptor–mediated induction of matrix metalloproteinase by tissue plasminogen activator

2003 • 449 citations

Spreading and Synchronous Depressions of Cortical Activity in Acutely Injured Human Brain

2002 • 423 citations

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

1999 • 403 citations

Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester

1993 • 388 citations

Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus

2002 • 383 citations

Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

2001 • 382 citations

Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

2001 • 382 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Spreading depression is not associated with neuronal injury in the normal brain

1988 • 365 citations

Matrix Metalloproteinase-9 Is Necessary for the Regulation of Smooth Muscle Cell Replication and Migration After Arterial Injury

2002 • 325 citations

PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

1944 • 319 citations

Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases

2002 • 313 citations

Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

1993 • 305 citations

Simulated Seizures and Spreading Depression in a Neuron Model Incorporating Interstitial Space and Ion Concentrations

2000 • 302 citations

Cortical Negative DC Deflections following Middle Cerebral Artery Occlusion and KCl-Induced Spreading Depression: Effect on Blood Flow, Tissue Oxygenation, and Electroencephalogram

1994 • 297 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

1997 • 281 citations

Matrix Metalloproteinases Contribute to Brain Damage in Experimental Pneumococcal Meningitis

2000 • 259 citations

Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells

1996 • 253 citations

Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

2000 • 252 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

Perspectives on spreading depression

2000 • 242 citations

Neuronal and glial activity during spreading depression in cerebral cortex of cat

1975 • 225 citations

Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator

1996 • 219 citations

Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury

2002 • 205 citations

Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo

2000 • 187 citations

Spatiotemporal Expression Patterns of Metalloproteinases and Their Inhibitors in the Postnatal Developing Rat Cerebellum

1999 • 185 citations

Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels

1999 • 171 citations

Cortical Spreading Depression Induces Proinflammatory Cytokine Gene Expression in the Rat Brain

2001 • 166 citations

Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

2002 • 149 citations

Impaired blood–brain barrier function in angiotensinogen-deficient mice

1998 • 143 citations

Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?

2003 • 130 citations

Transient global amnesia: a review emphasizing pathogenic aspects

2000 • 124 citations

Photothrombotic Infarction Triggers Multiple Episodes of Cortical Spreading Depression in Distant Brain Regions

1994 • 111 citations

Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle‐derived cell line

1993 • 105 citations

Multiple-Dose Mannitol Reduces Brain Water Content in a Rat Model of Cortical Infarction

1997 • 98 citations

Calcium Ion Transients in Peri-Infarct Depolarizations May Deteriorate Ion Homeostasis and Expand Infarction in Focal Cerebral Ischemia in Cats

2001 • 74 citations

Matrix metalloproteinase-9 is increased and correlates with severity in Guillain-Barré syndrome

1999 • 69 citations

The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat

1997 • 59 citations

Quantitative Analysis of Microvascular Alterations in Traumatic Brain Injury by Endothelial Barrier Antigen Immunohistochemistry

2001 • 52 citations

Quantitative assessment of the normal cerebral microvasculature by endothelial barrier antigen (EBA) immunohistochemistry: application to focal cerebral ischemia

2000 • 51 citations

In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells

2003 • 43 citations

Nitric Oxide Formation during Cortical Spreading Depression is Critical for Rapid Subsequent Recovery of Ionic Homeostasis

2002 • 42 citations

Increases in matrix metalloproteinase‐9 and tissue inhibitor of matrix metalloproteinase‐1 mRNA after cerebral contusion and depolarisation

2003 • 39 citations

Electron microscope study of blood–brain barrier opening induced by immunological targeting of the endothelial barrier antigen

2002 • 37 citations

Cortical Spreading Depression Causes a Long-Lasting Decrease in Cerebral Blood Flow and Induces Tolerance to Permanent Focal Ischemia in Rat Brain

2003 • 18 citations

Directed sampling for electrolyte analysis and water content of micro-punch samples shows large differences between normal and ischemic rat brain cortex

2000 • 18 citations