Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Apoptotic Pathways

2000 • 993 citations

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.

1988 • 871 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

The proprotein convertases

1998 • 648 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Mechanisms for pro matrix metalloproteinase activation

1999 • 436 citations

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

1999 • 428 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

1996 • 358 citations

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

2000 • 350 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

Caspases – controlling intracellular signals by protease zymogen activation

2000 • 329 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation

2000 • 310 citations

Regulation of Membrane Type-1 Matrix Metalloproteinase Activation by Proprotein Convertases

2000 • 307 citations

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

1998 • 295 citations

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.

1997 • 281 citations

A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase

2000 • 268 citations

Epilysin, a Novel Human Matrix Metalloproteinase (MMP-28) Expressed in Testis and Keratinocytes and in Response to Injury

2001 • 265 citations

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP

1999 • 261 citations

Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.

1999 • 257 citations

Maturation and Pro-peptide Cleavage of β-Secretase

2000 • 247 citations

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

1999 • 226 citations

Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface

1998 • 223 citations

Expression and Tissue Localization of Membrane-Type 1, 2, and 3 Matrix Metalloproteinases in Human Astrocytic Tumors

1999 • 220 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin

1983 • 208 citations

Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage

1999 • 203 citations

Cell surface activation of progelatinase A (proMMP-2) and cell migration

1998 • 201 citations

Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family

2001 • 188 citations

Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)

1999 • 155 citations

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.

1994 • 151 citations

Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.

1993 • 149 citations

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate

1988 • 142 citations

Matrix Metalloproteinase Inhibition: From The Jurassic To The Third Millennium

1999 • 134 citations

Regulation of Human ADAM 12 Protease by the Prodomain

1999 • 125 citations

Expression of Three Membrane-type Matrix Metalloproteinases (MT-MMPs) in Rat Vascular Smooth Muscle Cells and Characterization of MT3-MMPs with and without Transmembrane Domain

1997 • 117 citations

Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase-dependent Human Melanoma Invasion into Type I Collagen

2001 • 99 citations

Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor

1998 • 97 citations

Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the amino-terminal end of the activated enzyme

1988 • 91 citations

The PC6B Cytoplasmic Domain Contains Two Acidic Clusters That Direct Sorting to Distincttrans-Golgi Network/Endosomal Compartments

2000 • 79 citations

Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

1996 • 74 citations

The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast

1993 • 63 citations

Functional characterization of MT3‐MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3‐D collagen lattice

2000 • 54 citations

CA‐MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch

1999 • 53 citations

EXPRESSION OF MESSENGER RNAS FOR MEMBRANE-TYPE 1, 2, AND 3 MATRIX METALLOPROTEINASES IN HUMAN RENAL CELL CARCINOMAS

1999 • 40 citations

Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues

1998 • 39 citations

Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa.

2000 • 32 citations

A High-Level Mammalian Expression System Based on the Madin–Darby Canine Kidney Cell Line

1998 • 17 citations

What Structure and Function of Avian Plasminogen Activator and Matrix Metalloproteinase-2 Reveal about Their Counterpart Mammalian Enzymes, Their Regulation and Their Role in Tumor Invasion

1996 • 10 citations