Matrix Metalloproteinases and Neuroinflammation in Multiple Sclerosis

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Multiple Sclerosis

2000 • 2,813 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Molecular architecture of basement membranes

1990 • 937 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Quantitative Zymography: Detection of Picogram Quantities of Gelatinases

1994 • 866 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

1998 • 731 citations

Collagenase-induced intracerebral hemorrhage in rats.

1990 • 584 citations

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

1999 • 583 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

1999 • 548 citations

Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

1997 • 534 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis

1996 • 444 citations

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

1935 • 433 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Targeting leukocyte MMPs and transmigration

2002 • 413 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

1947 • 398 citations

SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS

1988 • 397 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

2001 • 382 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis

2003 • 354 citations

Matrix Metalloproteinases in Cerebrovascular Disease

1998 • 353 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

A comparison of the pathology of primary and secondary progressive multiple sclerosis

1994 • 289 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Multiple sclerosis: gadolinium enhancement in MR imaging.

1986 • 276 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system

1999 • 268 citations

XVIII.–The Histology of Disseminated Sclerosis

1916 • 268 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Blood–brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis

2004 • 265 citations

Extracellular Matrix Degradation

1991 • 262 citations

Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window

1995 • 260 citations

Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions

1999 • 259 citations

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

2003 • 258 citations

Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

2000 • 252 citations

Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis

1998 • 248 citations

THE HISTOLOGY OF DISSEMINATED SCLEROSIS.

1916 • 245 citations

BLOOD-BRAIN BARRIER DAMAGE IN ACUTE MULTIPLE SCLEROSIS PLAQUES

1991 • 235 citations

Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis

1999 • 232 citations

Extracellular matrix degradation by metalloproteinases and central nervous system diseases

1999 • 230 citations

Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis

2001 • 225 citations

Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction.

1975 • 224 citations

Binswanger's disease--revisited

1995 • 223 citations

Multiple Sclerosis: Current Pathophysiological Concepts

2001 • 221 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia

1999 • 204 citations

White Matter Damage Is Associated With Matrix Metalloproteinases in Vascular Dementia

2001 • 199 citations

Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

1999 • 199 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium

2000 • 190 citations

Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)

1996 • 182 citations

Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

1997 • 169 citations

Matrix metalloproteinases in inflammatory demyelination

1999 • 168 citations

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis

2001 • 165 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

PROTEOLYTIC ACTIVITY AND BASIC PROTEIN LOSS IN AND AROUND MULTIPLE SCLEROSIS PLAQUES: COMBINED BIOCHEMICAL AND EIISTOCHEMICAL OBSERVATIONS

1972 • 162 citations

Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity

1992 • 149 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases

2001 • 144 citations

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

1999 • 127 citations

Downregulation of Matrix Metalloproteinase-9 and Attenuation of Edema via Inhibition of ERK Mitogen Activated Protein Kinase in Traumatic Brain Injury

2002 • 127 citations

Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon‐β therapy in relapsing and secondary‐progressive multiple sclerosis patients

2001 • 125 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

1980 • 114 citations

Chronic Cerebral Hypoperfusion Induces MMP-2 but Not MMP-9 Expression in the Microglia and Vascular Endothelium of White Matter

2001 • 111 citations

Experimental allergic encephalomyelitis: role of fibrin deposition in immunopathogenesis of inflammation in rats.

1976 • 109 citations

Overexpression of Copper and Zinc Superoxide Dismutase in Transgenic Mice Prevents the Induction and Activation of Matrix Metalloproteinases after Cold Injury-Induced Brain Trauma

2000 • 107 citations

Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis

2002 • 103 citations

Proteolysis and myelin breakdown: a review of recent histochemical and biochemical studies

1969 • 101 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Protease production by cultured microglia: Substrate gel analysis and immobilized matrix degradation

1993 • 83 citations

Matrix metalloproteinase expression during experimental autoimmune neuritis

1998 • 83 citations

Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases

2000 • 82 citations

The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis

1995 • 76 citations

The inflammatory response in the CNS

1992 • 72 citations

Active Multiple Sclerosis

1978 • 71 citations

Neutral proteases and disruption of the blood–brain barrier in rat

1997 • 70 citations

VASCULAR ARCHITECTURE OF THE LESIONS OF MULTIPLE SCLEROSIS

1937 • 69 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis.

1972 • 67 citations

Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFα inhibitor in SCID mice with HIV-1 encephalitis

2001 • 64 citations

Synthetic Inhibitors of Matrix Metalloproteinases

1998 • 64 citations

Immunological effects of oral high‐dose methylprednisolone in acute optic neuritis and multiple sclerosis

2000 • 63 citations

IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS

1947 • 52 citations

Action of proteolytic and glycolytic enzymes on the permeability of the blood-brain barrier.

1974 • 44 citations

Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis.

1996 • 43 citations

The Up-regulation of Stromelysin-1 (MMP-3) in a Spontaneously Demyelinating Transgenic Mouse Precedes Onset of Disease

2002 • 40 citations

Observations on the effects of protease inhibitors on the suppression of experimental allergic encephalomyelitis

1982 • 38 citations

v-Ha-RaS oncogene upregulates the 92-kDa type IV collagenase (MMP-9) gene by increasing cellular superoxide production and activating NF-κB

2001 • 37 citations

Matrix metalloproteinase 9 (gelatinase B) in cerebrospinal fluid of HTLV‐1 infected patients with tropical spastic paraparesis

1998 • 34 citations

Fibrinolytic Activity of Plaques and White Matter in Multiple Sclerosis

1981 • 22 citations

Demyelinating diseases: from pathogenesis to repair strategies

2001 • 10 citations

Fibrinolytic activity of venous blood of patients with multiple sclerosis

1969 • 5 citations

Deleted Work

1955 • 0 citations