VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain

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1986 • 3,711 citations

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FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

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Magnetic resonance imaging of perfusion using spin inversion of arterial water.

1992 • 1,497 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

A Functional MRI Study of Subjects Recovered From Hemiparetic Stroke

1997 • 998 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Role of angiogenesis in patients with cerebral ischemic stroke.

1994 • 820 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

Untitled

1996 • 780 citations

Individual patterns of functional reorganization in the human cerebral cortex after capsular infraction

1993 • 741 citations

Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System

1999 • 732 citations

The Rotarod Test: An Evaluation of Its Effectiveness in Assessing Motor Deficits Following Traumatic Brain Injury

1994 • 616 citations

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

1994 • 616 citations

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

1996 • 500 citations

Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link?

1993 • 474 citations

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1999 • 457 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

Enhanced Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery With <scp>d</scp> -Amphetamine Therapy After Neocortical Infarction in Rats

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A rat model of focal embolic cerebral ischemia

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Tactile extinction: Distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage

1982 • 323 citations

Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats

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Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia

1998 • 308 citations

Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion

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Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.

1985 • 300 citations

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1996 • 280 citations

VEGF and flt

1996 • 276 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

1996 • 245 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and its Receptors (Flt-1 and Flk-1) following Permanent and Transient Occlusion of the Middle Cerebral Artery in the Rat

1998 • 236 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy

2000 • 235 citations

VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway

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Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF ₁₂₁ and VEGF ₁₆₅ but not VEGF ₁₈₉

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A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*

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Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

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Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor

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1990 • 176 citations

Microtubule‐Associated Protein 2 as an Early Indicator of Ischemia‐Induced Neurodegeneration in the Gerbil Forebrain

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Role of vascular endothelial cell growth factor in Ovarian Hyperstimulation Syndrome.

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Molecular analysis of blood vessel formation and disease

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Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence.

1993 • 155 citations

Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.

1995 • 118 citations

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

1996 • 117 citations

Quantitative measurement of motor and somatosensory impairments after mild (30 min) and severe (2 h) transient middle cerebral artery occlusion in rats

2000 • 113 citations

Prediction of Impending Hemorrhagic Transformation in Ischemic Stroke Using Magnetic Resonance Imaging in Rats

1998 • 111 citations

Diffusion-, T₂-, and Perfusion-Weighted Nuclear Magnetic Resonance Imaging of Middle Cerebral Artery Embolic Stroke and Recombinant Tissue Plasminogen Activator Intervention in the Rat

1998 • 97 citations

Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia

1988 • 97 citations

Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat

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The temporal evolution of MRI tissue signatures after transient middle cerebral artery occlusion in rat

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Blood flow through cerebral collateral vessels one month after middle cerebral artery occlusion.

1987 • 86 citations

Vascular endothelial growth factor. 20th-century mechanisms, 21st-century therapies.

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The role of polypeptide growth factors in recovery from stroke.

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Regeneration of cerebral microvessels: a morphologic and histochemical study after local freeze-injury.

1979 • 62 citations

Quantitation of Microvascular Plasma Perfusion and Neuronal Microtubule-Associated Protein in Ischemic Mouse Brain by Laser-Scanning Confocal Microscopy

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Outward K+ current in epithelial cells isolated from intermediate portion of endolymphatic sac of guinea pigs

1996 • 52 citations

Correlation Between Fibroblast Growth Factor Expression and Cell Proliferation in Experimental Brain Infarct: Studied with Proliferating Cell Nuclear Antigen Immunohistochemistry

1994 • 52 citations

Imaging System for Three-Dimensional Mapping of Cerebrocortical Capillary Networks in Vivo

1993 • 50 citations

Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats

1993 • 48 citations

Substantially attenuated hemodynamic responses to Escherichia coli-derived vascular endothelial growth factor given by intravenous infusion compared with bolus injection.

1998 • 45 citations

The microvascular system in ischemic cortical lesions

1996 • 39 citations

Combined effects of magnetization transfer and gadolinium in cranial MR imaging and MR angiography.

1995 • 37 citations

Role of blood-brain barrier permeability in focal ischemic brain edema.

1990 • 33 citations

Three-dimensional morphological study of microvascular regeneration in cavity wall of the rat cerebral cortex using the scanning electron microscope: Implications for delayed neural grafting into brain cavities

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Effects of Vascular Permeability Factor on the Permeability of Cultured Endothelial Cells from Brain Capillaries

1998 • 28 citations

Analysis of the evolution of focal cerebral ischemia in the rat using the eigenimage filter

1992 • 25 citations

Characterization of a protein product of human malignant glial tumors that induces microvascular permeability.

1990 • 24 citations

Reorganizing the brain

1998 • 7 citations