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Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders

Data up to Jan 2025

Published2002
Citations246
References213

Total Citations Per Year

Abstract

References (213)

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Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia

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Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

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Delivery of Neurotrophic Factors to the Central Nervous System

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VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1999 • 457 citations

Amyotrophic Lateral Sclerosis

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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)

1995 • 435 citations

Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease

2002 • 409 citations

A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1

1998 • 408 citations

Correlation of VEGF and Angiopoietin Expression with Disruption of Blood–Brain Barrier and Angiogenesis after Focal Cerebral Ischemia

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The role of the 5′ untranslated region of an mRNA in translation regulation during development

1999 • 369 citations

Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor

2000 • 369 citations

Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration

2000 • 364 citations

Neuropilin-2 Regulates the Development of Select Cranial and Sensory Nerves and Hippocampal Mossy Fiber Projections

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Effect of recombinant human insulin-like growth factor-I on progression of ALS

1997 • 359 citations

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Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders

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Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.

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A placebo‐controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis

1996 • 340 citations

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

1998 • 338 citations

Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia

2002 • 335 citations

Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

2000 • 323 citations

Linkage of Familial Amyotrophic Lateral Sclerosis With Frontotemporal Dementia to Chromosome 9q21-q22

2000 • 316 citations

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

2002 • 313 citations

Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats

1997 • 311 citations

Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia

1998 • 308 citations

Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide

2000 • 308 citations

Reversal of experimental diabetic neuropathy by VEGF gene transfer

2001 • 302 citations

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

1994 • 297 citations

Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity

2000 • 297 citations

Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA

1998 • 290 citations

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

2000 • 289 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy

2000 • 287 citations

Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt

2002 • 285 citations

VEGF and flt

1996 • 276 citations

Vascular endothelial growth factor rescues hippocampal neurons from glutamate‐induced toxicity: signal transduction cascades

2001 • 267 citations

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling

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Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System

2002 • 267 citations

Induction of Astrocyte Differentiation by Endothelial Cells

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Proliferation of Parenchymal Neural Progenitors in Response to Injury in the Adult Rat Spinal Cord

2001 • 251 citations

A dose‐dependent facilitation and inhibition of peripheral nerve regeneration by brain‐derived neurotrophic factor

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Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain

2000 • 241 citations

Cell Type Specific Upregulation of Vascular Endothelial Growth Factor in an MCA-occlusion Model of Cerebral Infarct

1999 • 240 citations

Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury

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Small Vessel Disease and Alzheimer’s Dementia: Pathological Considerations

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Expression of Vascular Endothelial Growth Factor (VEGF) and its Receptors (Flt-1 and Flk-1) following Permanent and Transient Occlusion of the Middle Cerebral Artery in the Rat

1998 • 236 citations

Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy

2000 • 235 citations

Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures

1999 • 234 citations

Interindividual Heterogeneity in the Hypoxic Regulation of VEGF

1999 • 232 citations

In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord

2002 • 231 citations

Familial amyotrophic lateral sclerosis

2002 • 231 citations

Semaphorin 3A–Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor

2001 • 227 citations

Molecular Changes in Normal Appearing White Matter in Multiple Sclerosis are Characteristic of Neuroprotective Mechanisms Against Hypoxic Insult

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From Charcot to SOD1

1999 • 224 citations

Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults.

1998 • 217 citations

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

2001 • 214 citations

Neurotrophic Effects of Vascular Endothelial Growth Factor on Organotypic Cortical Explants and Primary Cortical Neurons

2003 • 202 citations

The Blood‐Brain Barrier and Cerebrovascular Pathology in Alzheimer's Disease

1999 • 200 citations

Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF)

1999 • 199 citations

Lymphangiogenesis and tumor metastasis

2003 • 195 citations

The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids

1999 • 193 citations

Riluzole enhances expression of brain‐derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus

2002 • 192 citations

VEGF is a chemoattractant for FGF-2–stimulated neural progenitors

2003 • 191 citations

Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect

2001 • 190 citations

Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia

1998 • 190 citations

Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts

1999 • 188 citations

Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain

2002 • 183 citations

Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability

1998 • 182 citations

Increased Survival and Function of SOD1 Mice After Glial Cell-Derived Neurotrophic Factor Gene Therapy

2002 • 177 citations

Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression

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Pathology and pathogenetic mechanisms of diabetic neuropathy

1995 • 177 citations

Altered angioarchitecture in selected areas of brains with Alzheimer's disease

1990 • 176 citations

Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells

2002 • 176 citations

Vascular Endothelial Growth Factor Is Expressed in Multiple Sclerosis Plaques and Can Induce Inflammatory Lesions in Experimental Allergic Encephalomyelitis Rats

2002 • 175 citations

Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral Sclerosis

1998 • 171 citations

Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2

1999 • 160 citations

Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor

2001 • 156 citations

Spinal Cord Ischemia

2000 • 153 citations

Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke.

1999 • 153 citations

Expression of vascular endothelial growth factor and its receptors in rat neural stem cells

2003 • 151 citations

VPF/VEGF and the angiogenic response

2000 • 150 citations

Role of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trauma

1997 • 149 citations

VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death

2003 • 142 citations

Reactive oxygen species and the neurodegenerative disorders.

1997 • 141 citations

Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair

2003 • 138 citations

A Novel Locus for Familial Amyotrophic Lateral Sclerosis, on Chromosome 18q

2002 • 138 citations

Lymphangiogenic growth factors, receptors and therapies

2003 • 136 citations

Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen‐induced and collagen‐induced models of arthritis

2003 • 135 citations

Identification of Two Novel Loci for Dominantly Inherited Familial Amyotrophic Lateral Sclerosis

2003 • 131 citations

Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor

2002 • 124 citations

Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat

1998 • 119 citations

Improvement in Chronic Ischemic Neuropathy After Intramuscular phVEGF165 Gene Transfer in Patients With Critical Limb Ischemia

2001 • 118 citations

Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism

2002 • 118 citations

Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats

1999 • 116 citations

Vascular Endothelial Growth Factor Rescues HN33 Neural Cells from Death Induced by Serum Withdrawal

2000 • 116 citations

VEGF mRNA and Its Receptorflt-1Are Expressed in Reactive Astrocytes Following Neural Grafting and Tumor Cell Implantation in the Adult CNS

1998 • 116 citations

Neurodegeneration: a failure of neuroregeneration?

2001 • 115 citations

Oxidative stress in amyotrophic lateral sclerosis

2000 • 113 citations

VEGF mRNA Induction Correlates With Changes in the Vascular Architecture Upon Spinal Cord Damage in the Rat

1997 • 113 citations

New Vascular Endothelial Growth Factor Isoform Generated by Internal Ribosome Entry Site-Driven CUG Translation Initiation

2001 • 113 citations

Autosomal dominant juvenile amyotrophic lateral sclerosis

1999 • 113 citations

Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice

2001 • 108 citations

Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration

2000 • 108 citations

Cell Type-Specific Expression of Neuropilins in an MCA-Occlusion Model in Mice Suggests a Potential Role in Post-Ischemic Brain Remodeling

2002 • 106 citations

DIABETIC NEUROPATHY

1998 • 102 citations

VEGF and vascular changes in chronic neuroinflammation

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Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume

2003 • 95 citations

Neural stem cells

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Cerebral Hypoperfusion, Capillary Degeneration, and Development of Alzheimer Disease

2000 • 88 citations

Two Families with Familial Amyotrophic Lateral Sclerosis Are Linked to a Novel Locus on Chromosome 16q

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Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: A SPECT study

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The vascular endothelial growth factor mRNA contains an internal ribosome entry site

1998 • 82 citations

VEGF165 therapy exacerbates secondary damage following spinal cord injury.

2003 • 82 citations

The genetic and molecular mechanisms of motor neuron disease

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Similar Ultrastructural Breakdown of Cerebrocortical Capillaries in Alzheimer's Disease, Parkinson's Disease, and Experimental Hypertension: What is the Functional Link?

2000 • 68 citations

Development and Remodeling of Cerebral Blood Vessels and Their Flow in Postnatal Mice Observed with in vivo Videomicroscopy

1992 • 67 citations

Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells

2003 • 61 citations

Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension

2002 • 60 citations

Glial cell line‐derived neurotrophic factor increases calcitonin gene‐related peptide immunoreactivity in sensory and motoneurons in vivo

2003 • 60 citations

Expression of vascular endothelial growth factor (VEGF) and VEGF receptor-1 (Flt-1) in Graves disease possibly correlated with increased vascular density

2001 • 59 citations

Enhancement of ischemia‐induced tyrosine phosphorylation of Kv1.2 by vascular endothelial growth factor via activation of phosphatidylinositol 3‐kinase

2003 • 58 citations

Role of vascular endothelial growth factor in neuronal DNA damage and repair in rat brain following a transient cerebral ischemia

2002 • 58 citations

Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension

2003 • 55 citations

VEGF gene transfer for diabetic neuropathy.

2001 • 55 citations

Chronic ischemic monomelic neuropathy from critical limb ischemia

2001 • 52 citations

Vascular endothelial growth/permeability factor in spinal cord injury

1999 • 49 citations

The aetiology of idiopathic Parkinson's disease.

2001 • 47 citations

Vascular endothelial growth factor inhibits outward delayed-rectifier potassium currents in acutely isolated hippocampal neurons

2003 • 43 citations

Vascular endothelial growth factor‐B and retinal vascular development in the mouse

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Molecular Targeting of Lymphatics for Therapy

2004 • 36 citations

Expression of angiogenic factors in rabbit spinal cord after transient ischaemia

1999 • 36 citations

Vascular and metabolic reserve in Alzheimer’s disease

2000 • 34 citations

Vascular Endothelial Growth Factor in Brains With Periventricular Leukomalacia

1998 • 33 citations

The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis

2003 • 29 citations

Morphological Changes of Microvessels in the Brain with Alzheimer's Disease

1988 • 23 citations

Animal models for motor neuron disease.

1999 • 22 citations

Regeneration in vascularized and free nerve grafts

1986 • 21 citations

Immunohistochemical nitrotyrosine distribution in neonatal rat cerebrocortical slices during and after hypoxia

1999 • 19 citations

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex (DDPAC) is a non-Alzheimer’s frontotemporal dementia

1997 • 17 citations

Ischemic Peripheral Neuropathy

2001 • 16 citations

Local cerebral blood flow in motor neuron disease: correlation with clinical findings

1996 • 15 citations

Ischemic stroke syndromes: classification, pathophysiology and clinical features.

1998 • 1 citations

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