Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Determination and analysis of the 2 Å structure of copper, zinc superoxide dismutase

1982 • 932 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

Clinical limits of amyotrophic lateral sclerosis.

1982 • 372 citations

Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

1985 • 369 citations

Human motor neuron diseases.

1982 • 352 citations

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

1990 • 336 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Fine Structural Study of Neurofibrillary Changes in a Family with Amyotrophic Lateral Sclerosis

1984 • 300 citations

Familial Amyotrophic Lateral Sclerosis

1967 • 235 citations

Inciting Excitotoxic Cytocide Among Central Neurons

1986 • 231 citations

Excitotoxicity, free radicals, and cell membrane changes

1994 • 228 citations

Enzyme function of copper, zinc superoxide dismutase as a free radical generator.

1993 • 224 citations

Rapid Communication: Cu/Zn Superoxide Dismutase Activity in Familial and Sporadic Amyotrophic Lateral Sclerosis

1994 • 161 citations

Amyotrophic Lateral Sclerosis

1986 • 105 citations

AN INHERITED DISEASE SIMILAR TO AMYOTROPHIC LATERAL SCLEROSIS WITH A PATTERN OF POSTERIOR COLUMN INVOLVEMENT. AN INTERMEDIATE FORM?

1959 • 95 citations

Some sulfhydryl properties and primary structure of human erythrocyte superoxide dismutase

1980 • 87 citations

A Novel Mutation in Cu/Zn Superoxide Dismutase Gene in Japanese Familial Amyotrophic Lateral Sclerosis

1994 • 84 citations

The complete amino acid sequence of human Cu/Zn superoxide dismutase

1980 • 84 citations

Identification of a new missense point mutation in exon 4 of the Cu/Zn superoxide dismutase (SOD-1) gene in a family with amyotrophic lateral sclerosis

1994 • 70 citations

SOD1 missense mutation in an Italian family with ALS

1994 • 59 citations

Familial motor neuron diseases.

1982 • 53 citations

Excitatory amino acids, free radicals and the pathogenesis of motor neuron disease

1994 • 38 citations

Excitatory amino acid neurotoxicity in the hippocampal slice preparation

1988 • 34 citations

Molecular genetics of familial amyotrophic lateral sclerosis.

1991 • 25 citations

Pathophysiology of ischemic brain injury.

1989 • 20 citations

Pathnophysiology of Ischemic Brain Injury

1989 • 17 citations

The role of the active site amino acid residues on the catalytic activity of Cu2Zn2SOD

1993 • 7 citations