Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration

Mechanisms of angiogenesis

1997 • 5,696 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

1992 • 880 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

1997 • 728 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Astroglia in CNS injury

1991 • 496 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

Interferon-γ: Biology and Role in Pathogenesis

1996 • 433 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord

1999 • 409 citations

Expression of Pro‐Inflammatory Cytokine and Chemokine mRNA Upon Experimental Spinal Cord Injury in Mouse: an In Situ Hybridization Study

1997 • 354 citations

Angiogenesis in malignant gliomas

1995 • 340 citations

Expression of the Gene Encoding the Chemorepellent Semaphorin III Is Induced in the Fibroblast Component of Neural Scar Tissue Formed Following Injuries of Adult But Not Neonatal CNS

1999 • 308 citations

Effects of Transforming Growth Factor β₁, on Scar Production in the Injured Central Nervous System of the Rat

1994 • 302 citations

Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia

1998 • 298 citations

Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.

1999 • 292 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

Deposition of Scar Tissue in the Central Nervous System

1983 • 285 citations

VEGF and flt

1996 • 276 citations

Hypoxia Regulates the Expression of Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) and its Receptors in Human Skin

1997 • 274 citations

Enhanced expression of transforming growth factor β1 in the rat brain after a localized cerebral injury

1992 • 220 citations

Vascular Endothelial Growth Factor (VEGF) Modulates Vascular Permeability and Inflammation in Rat Brain

1999 • 216 citations

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1998 • 207 citations

Meningiomas: Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in Angiogenesis and Peritumoral Edema

1997 • 202 citations

Cyclooxygenase‐2 is induced globally in infarcted human brain

1998 • 193 citations

Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts

1999 • 188 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Peritumoral brain edema associated with meningioma

1999 • 171 citations

Brain Edema in Meningiomas Is Associated with Increased Vascular Endothelial Growth Factor Expression

1997 • 170 citations

Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia

1999 • 169 citations

Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

2000 • 164 citations

A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade

2000 • 160 citations

Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke.

1999 • 153 citations

Role of Cyclooxygenase 2 in Acute Spinal Cord Injury

1998 • 150 citations

Role of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trauma

1997 • 149 citations

Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas

1996 • 142 citations

Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells.

1998 • 132 citations

Gamma-interferon-like immunoreactivity in axotomized rat motor neurons

1989 • 126 citations

Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor‐β2

1999 • 123 citations

VEGF mRNA and Its Receptorflt-1Are Expressed in Reactive Astrocytes Following Neural Grafting and Tumor Cell Implantation in the Adult CNS

1998 • 116 citations

Angiogenesis and Brain Oedema in Intracranial Meningiomas: Influence of Vascular Endothelial Growth Factor

1998 • 116 citations

VEGF mRNA Induction Correlates With Changes in the Vascular Architecture Upon Spinal Cord Damage in the Rat

1997 • 113 citations

Decorin Attenuates Gliotic Scar Formation in the Rat Cerebral Hemisphere

1999 • 105 citations

Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: An experimental study in the rat

1993 • 103 citations

Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature

1999 • 102 citations

Reinnervation of the ventral root L7 from ventral horn neurons following intramedullary axotomy in adult cats

1983 • 100 citations

Macrophage/Microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-beta and basic fibroblast growth factor.

1997 • 97 citations

Expression of vascular endothelial growth factor in human brain tumors

1998 • 94 citations

A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse

1998 • 93 citations

Expression of MHC Class I and β2-Microglobulin in Rat Spinal Motoneurons: Regulatory Influences by IFN-Gamma and Axotomy

1998 • 89 citations

Macrophage/Microglia Regulation of Astrocytic Tenascin: Synergistic Action of Transforming Growth Factor-β and Basic Fibroblast Growth Factor

1997 • 87 citations

Expression of NMDA Receptor mRNAs in Rat Motoneurons is Down‐regulated after Axotomy

1995 • 87 citations

Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors

1998 • 85 citations

Expression of Cyclooxygenase-2 mRNA After Global Ischemia Is Regulated by AMPA Receptors and Glucocorticoids

1999 • 81 citations

Vascular endothelial growth factor (vascular permeability factor) expression in injured rat brain

1997 • 78 citations

Restricted Expression Pattern ofvegf-din the Adult and Fetal Mouse: High Expression in the Embryonic Lung

1999 • 59 citations

SPINAL CORD TRANSECTION: A QUANTITATIVE ANALYSIS OF ELEMENTS OF THE CONNECTIVE TISSUE MATRIX FORMED WITHIN THE SITE OF LESION FOLLOWING ADMINISTRATION OF PIROMEN, CYTOXAN OR TRYPSIN

1979 • 57 citations

Changes in nerve growth factor receptor-like immunoreactivity in the spinal cord after ventral funiculus lesion in adult cats

1992 • 46 citations

Ultrastructural study on meningeal regeneration and meningo-glial relationships after cerebral stab wound in the adult rat

1988 • 45 citations

Topical glucocorticoids modulate the lesion interface after cerebral cortical stab wounds in adult rats

1996 • 39 citations

Nerve Growth Factor Induces Process Formation in Meningeal Cells: Implications for Scar Formation in the Injured CNS

1998 • 38 citations

Adhesive/Repulsive Properties in the Injured Spinal Cord: Relation to Myelin Phagocytosis by Invading Macrophages

1994 • 36 citations

MHC Class II Engagement in Brain Endothelial Cells Induces Protein Kinase A-Dependent IL-6 Secretion and Phosphorylation of cAMP Response Element-Binding Protein

1999 • 29 citations

Microglia Exhibit Clonal Variability in Eliciting Cytotoxic T Lymphocyte Responses Independent of Class I Expression

1999 • 12 citations