Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Superoxide Dismutase Activity, Oxidative Damage, and Mitochondrial Energy Metabolism in Familial and Sporadic Amyotrophic Lateral Sclerosis

1993 • 627 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima

1997 • 470 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1995 • 464 citations

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

1994 • 458 citations

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

1996 • 450 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Peroxynitrite Inhibits Glutamate Transporter Subtypes

1996 • 375 citations

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

1994 • 356 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Oxidative damage to protein in sporadic motor neuron disease spinal cord

1995 • 326 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins

1990 • 249 citations

Excitotoxin Lesions in Primates as a Model for Huntington's Disease: Histopathologic and Neurochemical Characterization

1993 • 245 citations

SOD1 mutation is assosiated with accumulation of neurofilaments in amyotrophic lateral scelaries

1996 • 237 citations

Inflammation and NO_x-induced nitration: Assay for 3-nitrotyrosine by HPLC with electrochemical detection

1997 • 175 citations

Concurrent generation of nitric oxide and superoxide damages surfactant protein A

1994 • 172 citations

Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylylation: relevance to signal transduction.

1996 • 171 citations

The Oxidative Inactivation of Sarcoplasmic Reticulum Ca²⁺-ATPase by Peroxynitrite

1996 • 162 citations

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1996 • 157 citations

Superoxide Dismutase Concentration and Activity in Familial Amyotrophic Lateral Sclerosis

1995 • 125 citations

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND

1996 • 118 citations

Hydroxyl Radicals Generated In Vivo Kill Neurons in the Rat Spinal Cord: Electrophysiological, Histological, and Neurochemical Results

1994 • 110 citations

Peroxynitrite Formation from Activated Human Leukocytes

1996 • 66 citations

Hazards of antioxidant combinations containing superoxide dismutase

1995 • 28 citations

Neuroprotective strategies

2022 • 2 citations