VEGF mRNA and Its Receptorflt-1Are Expressed in Reactive Astrocytes Following Neural Grafting and Tumor Cell Implantation in the Adult CNS

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Astrocytes induce blood–brain barrier properties in endothelial cells

1987 • 1,593 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1995 • 990 citations

Methods in Neurosciences

1992 • 622 citations

Astrocyte Responses to CNS Injury

1994 • 596 citations

Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent

1996 • 570 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1993 • 467 citations

Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possibleIn vivo regulatory mechanisms

1994 • 464 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Changing role of forebrain astrocytes during development, regenerative failure, and induced regeneration upon transplantation

1986 • 383 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

VEGF and flt

1996 • 276 citations

Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes

1997 • 266 citations

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

1996 • 239 citations

Vascular permeability alterations to horseradish peroxidase in experimental brain injury

1978 • 219 citations

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1998 • 207 citations

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

1997 • 195 citations

In situ hybridization; a practical approach

1993 • 194 citations

Angiogenesis in developing rat brain: An in vivo and in vitro study

1985 • 184 citations

Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes

1987 • 164 citations

Role of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trauma

1997 • 149 citations

Neocortical Transplants in the Mammalian Brain Lack a Blood-Brain Barrier to Macromolecules

1987 • 131 citations

Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures

1995 • 125 citations

Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature

1997 • 119 citations

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

1996 • 117 citations

Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants

1988 • 96 citations

Re‐evaluating the role of astrocytes in blood‐brain barrier induction

1993 • 95 citations

Allografts of CNS tissue possess a blood-brain barrier

1991 • 85 citations

Reactive astrocytes involved in the formation of lesional scars differ in the mediobasal hypothalamus and in other forebrain regions

1993 • 81 citations

Vascular endothelial growth factor (vascular permeability factor) expression in injured rat brain

1997 • 78 citations

Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain

1997 • 74 citations

Brain angiogenesis: Variations in vascular basement membrane glycoprotein immunoreactivity

1991 • 73 citations

Alterations in Fibroblast Growth Factor Receptor Expression Following Brain Injury

1996 • 72 citations

Why Do Neural Transplants Survive?

1995 • 72 citations

Allografts of CNS tissue possess a blood‐brain barrier: III. Neuropathological, methodological, and immunological considerations

1994 • 54 citations

Gamma-glutanyl-transpeptidase (GGTP) and NA+K+-ATPase activities in different subpopulations of cloned cerebral endothelial cells: Reponses to glial stimulation

1990 • 54 citations

Patterns of angiogenesis in neural transplant models: I. Autonomic tissue transplants

1987 • 51 citations

A new role for vascular endothelial growth factor and fibroblast growth factors: increasing endothelial resistance to oxidative stress

1997 • 51 citations

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

1988 • 49 citations

Reversible blood-brain barrier dysfunction to peroxidase after a small stab wound in the rat cerebral cortex.

1976 • 47 citations

Regional heterogeneity among astrocytes in the central nervous system

1990 • 47 citations

On the regional distribution of heparan sulfate proteoglycan immunoreactivity in the rat brain

1994 • 40 citations

The fine structure of vascular-astroglial relations in transplanted fetal neocortex

1989 • 36 citations

Immunocytochemical expression of the blood—brain barrier glucose transporter (GLUT‐1) in neural transplants and brain wounds

1994 • 30 citations

Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study

1996 • 30 citations

Molecular, Cellular, and Clinical Aspects of Angiogenesis

1996 • 29 citations

Effect of astroglial degeneration on the blood-brain barrier to protein in neonatal rats

1993 • 24 citations

Effect of Astroglial Degeneration on Neonatal Blood–Brain Barrier Marker Expression

1996 • 22 citations

Permeability of the Blood–Brain Barrier to Protein and [3H]GABA in Intraparenchymal Fetal CNS Tissue Grafts

1996 • 18 citations

Cerebral endothelial regeneration following experimental brain injury

1989 • 15 citations

Excitatory amino acid regulation of astrocyte proteoglycans

1996 • 11 citations

Wound Healing Angiogenesis: The Metabolic Basis of Repair

1996 • 11 citations

Models of Angiogenesis and the Blood–Brain Barrier

1994 • 2 citations