Cellular adaptation to hypoxia: O₂‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O₂‐regulated gene expression

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1996 • 1,660 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

The PAS Superfamily: Sensors of Environmental and Developmental Signals

2000 • 1,030 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

1991 • 932 citations

Regulation of Human Placental Development by Oxygen Tension

1997 • 905 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein

2000 • 889 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

An essential role for p300/CBP in the cellular response to hypoxia

1996 • 780 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1997 • 775 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

2001 • 752 citations

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

2001 • 748 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia

2001 • 714 citations

Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

2001 • 704 citations

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

2001 • 666 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

1999 • 647 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1998 • 638 citations

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

2000 • 635 citations

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 • 633 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

2001 • 602 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

1998 • 572 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Identification of an angiogenic mitogen selective for endocrine gland endothelium

2001 • 549 citations

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

2000 • 529 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

Induction of HIF-1alpha in response to hypoxia is instantaneous.

2001 • 507 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

Mammalian Oxygen Sensing, Signalling and Gene Regulation

2000 • 453 citations

The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.

2000 • 452 citations

The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling

2000 • 451 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 443 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 421 citations

Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

2001 • 418 citations

Induction of HIF–1α in response to hypoxia is instantaneous

2001 • 416 citations

Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells

2001 • 415 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1997 • 406 citations

Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1

1997 • 400 citations

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans

2000 • 397 citations

Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death

1999 • 393 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

Synergistic Cooperation between Hypoxia and Transforming Growth Factor-β Pathways on Human Vascular Endothelial Growth Factor Gene Expression

2001 • 374 citations

Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

2000 • 371 citations

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

1997 • 368 citations

Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

2000 • 368 citations

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease

2001 • 364 citations

Identification of a Hypoxia Response Element in the Transferrin Receptor Gene

1999 • 359 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 355 citations

Transferrin Receptor Induction by Hypoxia

1999 • 352 citations

Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene

2002 • 341 citations

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

1998 • 333 citations

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α

2001 • 303 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

2000 • 287 citations

Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

2002 • 282 citations

Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein

1998 • 278 citations

Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency

2000 • 275 citations

Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand

1998 • 267 citations

A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α

2001 • 265 citations

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

2000 • 265 citations

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

2002 • 257 citations

Accumulation of HIF-1α under the influence of nitric oxide

2001 • 257 citations

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1999 • 243 citations

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

1999 • 241 citations

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

2000 • 237 citations

Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes

1998 • 233 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site

1995 • 228 citations

Early Expression of Myocardial HIF-1α in Response to Mechanical Stresses

2002 • 227 citations

Effect of Protein Kinase and Phosphatase Inhibitors on Expression of Hypoxia Inducible Factor 1

1995 • 225 citations

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia

1998 • 224 citations

aHIF: a Natural Antisense Transcript Overexpressed in Human Renal Cancer and During Hypoxia

1999 • 218 citations

Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells

1997 • 218 citations

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

2000 • 210 citations

Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

2001 • 207 citations

The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1

1995 • 200 citations

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

2000 • 196 citations

Jab1 Interacts Directly with HIF-1α and Regulates Its Stability

2002 • 193 citations

Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides

2000 • 188 citations

Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α

1999 • 186 citations

Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

2001 • 178 citations

A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor

2000 • 177 citations

Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.

2001 • 175 citations

Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells

2000 • 173 citations

EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK

1999 • 171 citations

Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1

1995 • 171 citations

Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia

1996 • 162 citations

Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

2001 • 161 citations

Heat Induction of the Unphosphorylated Form of Hypoxia-inducible Factor-1α Is Dependent on Heat Shock Protein-90 Activity

2002 • 153 citations

Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism

2001 • 150 citations

Oxygen‐regulated erythropoietin gene expression is dependent on a CpG methylation‐free hypoxia‐inducible factor‐1 DNA‐binding site

1998 • 139 citations

HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation

2001 • 138 citations

Characterization of an Oxygen/Redox-Dependent Degradation Domain of Hypoxia-Inducible Factor α (HIF-α) Proteins

1999 • 136 citations

Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway

2000 • 133 citations

Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways

2001 • 127 citations

Hypoxia Regulates the Expression of the Adrenomedullin and HIF-1 Genes in Cultured HL-1 Cardiomyocytes

1999 • 127 citations

Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

2001 • 126 citations

Molecular Mechanism of Hypoxia-inducible Factor 1α-p300 Interaction

2001 • 125 citations

Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain

2001 • 125 citations

Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene

1999 • 124 citations

The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription

2001 • 110 citations

Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks thetrans-Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1α

2001 • 110 citations

Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

2001 • 103 citations

O₂-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis

2000 • 101 citations

Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes

2001 • 98 citations

Mersalyl Is a Novel Inducer of Vascular Endothelial Growth Factor Gene Expression and Hypoxia-Inducible Factor 1 Activity

1998 • 92 citations

Absolute Requirement of Aryl Hydrocarbon Receptor Nuclear Translocator Protein for Gene Activation by Hypoxia

1996 • 91 citations

Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells

1997 • 89 citations

A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses

2001 • 88 citations

Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.

2001 • 86 citations

Dissecting hypoxia‐dependent and hypoxia‐independent steps in the HIF‐1α activation cascade: implications for HIF‐1α gene therapy

2001 • 83 citations

Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression

2001 • 76 citations

A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1α gene

2002 • 76 citations

Mouse Hypoxia-Inducible Factor-1α Is Encoded by Two Different mRNA Isoforms: Expression From a Tissue-Specific and a Housekeeping-Type Promoter

1998 • 74 citations

Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

2000 • 74 citations

Physiologically low oxygen concentrations determined in fetal skin regulate hypoxia‐inducible factor 1 and transforming growth factor β3

2002 • 72 citations

Complex role of protein phosphorylation in gene activation by hypoxia

1997 • 71 citations

Characterization of the α _1B -adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

1997 • 70 citations

Binding and regulation of HIF‐1α by a subunit of the proteasome complex, PSMA7

2001 • 61 citations

The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive

1997 • 59 citations

Hypoxia-inducible Mammalian Gene Expression Analyzed in Vivo at a TATA-driven Promoter and at an Initiator-driven Promoter

1998 • 57 citations

iNOS Expression Inhibits Hypoxia-Inducible Factor-1 Activity

2000 • 54 citations

Isoform-Specific Expression of Hypoxia-Inducible Factor-1α During the Late Stages of Mouse Spermiogenesis

2002 • 51 citations

Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxia

1999 • 43 citations

Hypoxia-Inducible Factor 1α and 1β Proteins Share Common Signaling Pathways in Human Prostate Cancer Cells

2001 • 42 citations

Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing

2000 • 40 citations

A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1α gene

2002 • 37 citations

Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor

2001 • 37 citations

Anoxic induction of a sarcoma virus-related VL30 retrotransposon is mediated by a cis-acting element which binds hypoxia-inducible factor 1 and an anoxia-inducible factor

1995 • 30 citations

In Vivo Analysis of DNA-Protein Interactions on the Human Erythropoietin Enhancer

1997 • 25 citations

Isoform-Specific Expression of Hypoxia-Inducible Factor-1 During the Late Stages of Mouse Spermiogenesis

2002 • 19 citations

Deleted Work

1955 • 0 citations