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Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

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Quantitative analysis of the olfactory pathway for drug delivery to the brain

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Physiology and Pathophysiology of the Cerebrospinal Fluid

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Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

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Drug Delivery to the Brain

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Glial Cell Line-Derived Neurotrophic Factor Protects against Ischemia-Induced Injury in the Cerebral Cortex

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Free insulin‐like growth factors (IGF‐I and IGF‐II) in human serum

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Peptide Drug Delivery to the Brain

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Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

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Keeping track of neurotrophin receptors

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A femtomolar-acting neuroprotective peptide.

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Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

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Lentiviral Vectors: Regulated Gene Expression

2000 • 242 citations

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

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Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway

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Research advances in Alzheimer's disease and related disorders

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Anatomical relationships of the pia mater to cerebral blood vessels in man

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Intraputaminal Infusion of Nerve Growth Factor to Support Adrenal Medullary Autografts in Parkinson's Disease

1991 • 219 citations

Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression

1994 • 213 citations

Distribution of extracellular tracers in perivascular spaces of the rat brain

1991 • 208 citations

Insulin and insulin-like growth factor receptors in the nervous system

1989 • 207 citations

Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium

1985 • 205 citations

Neural actions of immunophilin ligands

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TGF-β1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia

1996 • 202 citations

Nasal Route for Direct Delivery of Solutes to the Central Nervous System: Fact or Fiction?

1998 • 202 citations

Biopharmaceutical benchmarks

2000 • 200 citations

Distribution of nerve growth factor following direct delivery to brain interstitium

1995 • 200 citations

Neuroprotection with noninvasive neurotrophin delivery to the brain

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Intranasal drug delivery

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Delivery of¹²⁵I-NGF to the Brain via the Olfactory Route

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Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1991 • 190 citations

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Transcytotic pathway for blood-borne protein through the blood-brain barrier.

1988 • 188 citations

Central nervous system effects of intranasally administered insulin during euglycemia in men.

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Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide.

1996 • 181 citations

Delayed Treatment with Intravenous Basic Fibroblast Growth Factor Reduces Infarct Size following Permanent Focal Cerebral Ischemia in Rats

1995 • 180 citations

Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth

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Endocytic and exocytic pathways of the neuronal secretory process and trans synaptic transfer of wheat germ agglutinin‐horseradish peroxidase in vivo

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The neurotrophins and their receptors

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Tracer diffusion of globular proteins in concentrated protein solutions.

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Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

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Fibrolast growth factors in the nervous system

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Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration.

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OVERVIEW OF DRUG‐PROTEIN BINDING

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Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury

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Basic Fibroblast Growth Factor Increases Long-Term Survival of Spinal Motor Neurons and Improves Respiratory Function after Experimental Spinal Cord Injury

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α2-macroglobulin is a binding protein for basic fibroblast growth factor

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Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze.

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TGFβ1 and TGFβ2 Concentrations Are Elevated in Parkinson's Disease in Ventricular Cerebrospinal Fluid

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TGF-β in the central nervous system: Potential roles in ischemic injury and neurodegenerative diseases

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Bioavailability and Transport of Peptides and Peptide Drugs into the Brain

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Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo.

2000 • 146 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat

1986 • 144 citations

MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF)

1990 • 143 citations

Transplants and Neurotrophic Factors Prevent Atrophy of Mature CNS Neurons after Spinal Cord Injury

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Prospects for Pharmacological Intervention in Alzheimer Disease

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Cytokines which signal through the LIF receptor and their actions in the nervous system

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Peptides crossing the blood–brain barrier: some unusual observations

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The Transport of a Drug to the Cerebrospinal Fluid Directly from the Nasal Cavity: The Relation to the Lipophilicity of the Drug.

1991 • 136 citations

Alzheimer's disease may begin in the nose and may be caused by aluminosilicates

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Growth/Differentiation Factor-15/Macrophage Inhibitory Cytokine-1 Is a Novel Trophic Factor for Midbrain Dopaminergic NeuronsIn Vivo

2000 • 135 citations

Drug “Diffusion” within the Brain^a

1988 • 134 citations

Neurotrophin‐7: a novel member of the neurotrophin family from the zebrafish

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Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

1998 • 130 citations

Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans

1996 • 129 citations

Patterns of Insulin‐like Growth Factor and IGF Receptor Gene Expression in the Brain: Functional Implications

1993 • 129 citations

Surveillance for morbidity and mortality among older adults--United States, 1995-1996.

1999 • 129 citations

Neurotrophic Factors Enter the Clinic

1994 • 125 citations

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1999 • 124 citations

Diffusion of albumins in rat cortical slices and relevance to volume transmission

1996 • 121 citations

Development of pharmacological agents for targeting neurotrophins and their receptors

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Signaling of the Cardiotrophin-1 Receptor

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Characterization of Insulin-Like Growth Factor Binding Proteins Produced in the Rat Central Nervous System*

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Recommendations for Nomenclature of the Insulin-Like Growth Factor Binding Protein Superfamily

1998 • 115 citations

Cellular and Molecular Neurosurgery: Pathways from Concept to Reality-Part II: Vector Systems and Delivery Methodologies for Gene Therapy of the Central Nervous System

1997 • 114 citations

Entry of pathogens into the central nervous system

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Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor gp130 dependent pathways

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Intrathecal Ciliary Neurotrophic Factor Delivery for Treatment of Amyotrophic Lateral Sclerosis (Phase I Trial)

1997 • 107 citations

Direct Drug Transport from the Rat Nasal Cavity to the Cerebrospinal Fluid: the Relation to the Molecular Weight of Drugs

1995 • 106 citations

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1999 • 105 citations

Nasal swell-bodies and cyclic changes in the air passage of the rat and rabbit nose.

1971 • 104 citations

Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury

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Neurotrophic factors in the therapy of diabetic neuropathy

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The Blood-brain barrier : cellular and molecular biology

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Isolation of human nerve growth factor from placental tissue

1978 • 101 citations

Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus

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Entry of EGF into brain is rapid and saturable

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Transfer of dopamine in the olfactory pathway following nasal administration in mice.

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Identification of soluble forms of the fibroblast growth factor receptor in blood.

1994 • 97 citations

Transport and elimination of recombinant human NGF during long-term delivery to the brain

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Recombinant Human and Rat Ciliary Neurotrophic Factors

1991 • 96 citations

Receptor‐mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors

1991 • 96 citations

Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients

1991 • 96 citations

Hypoxia Dramatically Increases the Nonspecific Transport of Blood‐Borne Proteins to the Brain

1997 • 95 citations

Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor

2000 • 94 citations

Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor‐β superfamily, on midbrain dopaminergic neurons

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Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke

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Engineering targeted in vivo drug delivery. I. The physiological and physicochemical principles governing opportunities and limitations.

1986 • 89 citations

Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging

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Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.

1996 • 85 citations

A nose-brain pathway for psychotropic peptides: evidence from a brain evoked potential study with cholecystokinin

1996 • 84 citations

Molecular Mimics of Insulin-like Growth Factor 1 (IGF-1) for Inhibiting IGF-1: IGF-Binding Protein Interactions

1998 • 83 citations

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

1993 • 83 citations

Cholinesterase Inhibitor Therapy Stabilizes Symptoms of Alzheimer Disease

2000 • 83 citations

Role of Insulin‐like Growth Factor Binding Proteins in Modifying IGF Actions^a

1993 • 83 citations

Experimental Therapeutics of Neurodegenerative Disorders: Unmet Needs

1998 • 82 citations

Pharmacokinetics of Intrathecally Applied BDNF and Effects on Spinal Motoneurons

1996 • 80 citations

Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans

1999 • 79 citations

Glutaraldehyde fixation increases retention of low molecular weight proteins (growth factors) transferred to nylon membranes for Western blot analysis

1989 • 79 citations

Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug

1994 • 78 citations

Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury

1997 • 77 citations

Structural Determinants of Neurotrophin Action

1995 • 77 citations

The nasal route of cerebrospinal fluid drainage in man. A light–microscope study

1994 • 76 citations

Immunophilin Ligands and GDNF Enhance Neurite Branching or Elongation from Developing Dopamine Neurons in Culture

2000 • 76 citations

Intrathecal Drug Administration

1992 • 71 citations

A Phase I Study of Recombinant Human Ciliary Neurotrophic Factor (rHCNTF) in Patients with Amyotrophic Lateral Sclerosis

1995 • 70 citations

Insulin‐like Growth Factor Receptors: Implications for Nervous System Function

1993 • 70 citations

Transport of Insulin‐Related Peptides and Glucose across the Blood‐Brain Barrier^a

1993 • 68 citations

The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways.

1993 • 68 citations

Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor.

2000 • 66 citations

Total synthesis of insulin-like growth factor I (somatomedin C).

1983 • 66 citations

Stabilization of nerve growth factor in controlled release polymers and in tissue

1997 • 64 citations

Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging

1993 • 64 citations

Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: Correlation with the topographical distribution of trk a messenger RNA-expressing cells

1993 • 63 citations

Bone Morphogenetic Proteins and Bone Morphogenetic Protein Gene Therapy in Neurological Surgery: A Review

2000 • 63 citations

Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain

1999 • 62 citations

Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications

1999 • 61 citations

Mammalian GFRα-4, a Divergent Member of the GFRα Family of Coreceptors for Glial Cell Line-derived Neurotrophic Factor Family Ligands, Is a Receptor for the Neurotrophic Factor Persephin

2000 • 61 citations

Controlled Release of Proteins to Tissue Transplants for the Treatment of Neurodegenerative Disorders

1996 • 59 citations

AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells

1995 • 59 citations

Neuroprotective Utility and Neurotrophic Action of Neurturin in Postnatal Motor Neurons: Comparison with GDNF and Persephin

1999 • 58 citations

Interaction of nerve growth factor with murine α‐macroglobulin

1989 • 58 citations

Peptide and Protein Drug Analysis

1999 • 57 citations

Axonal regeneration of sensory nerves is delayed by continuous intrathecal infusion of nerve growth factor

1997 • 56 citations

The movement of IGF-I into the brain parenchyma after hypoxic-ischaemic injury

1996 • 56 citations

Insulinlike growth factor binding proteins

1997 • 55 citations

Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington’s disease

2000 • 55 citations

Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: immunological and biological specificity

1997 • 53 citations

Identical or Overlapping Sequences in the Primary Structure of Human α2-Macroglobulin Are Responsible for the Binding of Nerve Growth Factor-β, Platelet-derived Growth Factor-BB, and Transforming Growth Factor-β

2000 • 53 citations

Nerve Growth Factor Treatment in Dementia

2000 • 53 citations

Tracer diffusion of proteins in DNA solutions

1992 • 52 citations

Increased CSF levels of nerve growth factor in patients with Alzheimer’s disease

2000 • 52 citations

Evidence for pore-like opening of the blood-brain barrier following forebrain ischemia in rats

1997 • 51 citations

Localized delivery of proteins in the brain: can transport be customized?

1998 • 51 citations

Intravenous Fibroblast Growth Factor Penetrates the Blood-Brain Barrier and Protects Hippocampal Neurons Against Ischemia-Reperfusion Injury

1998 • 51 citations

Extracellular release as the major degradative pathway of the insulin-like growth factor II/mannose 6-phosphate receptor

1991 • 51 citations

Putrescine‐Modified Nerve Growth Factor: Bioactivity, Plasma Pharmacokinetics, Blood‐Brain/Nerve Barrier Permeability, and Nervous System Biodistribution

1998 • 51 citations

The Influence of the Blood Pressure in Urographic Examination

1950 • 50 citations

Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain

1996 • 49 citations

Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects

1987 • 49 citations

Neurotrophic Factors: What Are They and What Are They Doing?

1993 • 48 citations

Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: Distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons

1996 • 48 citations

Intracerebroventricular infusion of nerve growth factor induces pain-like response in rats

2000 • 48 citations

The Pharmacokinetics of Subcutaneously Administered Recombinant Human Ciliary Neurotrophic Factor (rHCNTF) in Patients with Amyotrophic Lateral Sclerosis

1995 • 47 citations

Behavioral effects of neurohypophyseal peptides in healthy volunteers: 10 years of research

1991 • 46 citations

The blood-brain barrier and multiple sclerosis

1994 • 46 citations

LIF (AM424), a promising growth factor for the treatment of ALS

1998 • 45 citations

Orally active NGF synthesis stimulators: potential therapeutic agents in alzheimer's disease

1997 • 45 citations

Pharmacological induction of physiologically active nerve growth factor in rat peripheral nervous system.

1993 • 44 citations

Tracer Diffusion of Proteins in DNA Solutions. 2. Green Fluorescent Protein in Crowded DNA Solutions

2000 • 43 citations

Interaction of Nerve Growth Factor with the Mouse-Brain Neurotubule Protein(s)

1974 • 42 citations

A Soluble brain molecule related to epidermal growth factor receptor is a mitogen inhibitor for astrocytes

1989 • 40 citations

Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration.

1996 • 39 citations

Gene Expression along the Cerebral-Spinal Axis after Regional Gene Delivery

1999 • 38 citations

Neurotrophic Factors in the Treatment of Peripheral Neuropathy

2007 • 37 citations

Chemistry, structure, and function of insulin-like growth factors and their receptors: a review

1984 • 37 citations

Kinetic analysis of the elimination process of human epidermal growth factor (hEGF) in rats

1989 • 37 citations

Synthesis, purification, and characterization of human ciliary neuronotrophic factor from E. coli

1991 • 37 citations

Human epidermal growth factor—on molecular forms present in urine and blood

1992 • 37 citations

TGFα and the Blood–Brain Barrier: Accumulation in Cerebral Vasculature

1999 • 36 citations

Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration

1999 • 35 citations

Glial growth factors I-III are specific mitogens for glial cells

1996 • 34 citations

Biochemistry and Molecular Biology of Fibroblast Growth Factors

1993 • 34 citations

Solution Structure and Internal Motion of a Bioactive Peptide Derived from Nerve Growth Factor

1998 • 34 citations

The first attempt at radioisotopic evaluation of the integrity of the nose-brain barrier

1997 • 33 citations

The pharmacokinetics of free insulin-like growth factor-I in healthy subjects

1999 • 33 citations

The blood-brain barrier to horseradish peroxidase at the onset of bicuculline-induced seizures in hypothalamus, pallidum, hippocampus, and other selected regions of the rabbit

1986 • 32 citations

Distribution of Radioiodinated Recombinant Human Nerve Growth Factor in Primate Brain Following Intracerebroventricular Infusion

1996 • 32 citations

Cholecystokinin-8 protects central cholinergic neurons against fimbria–fornix lesion through the up-regulation of nerve growth factor synthesis

1999 • 32 citations

The brain and the lymphatic system (I).

1996 • 32 citations

Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic–ischemic brain injury

2000 • 31 citations

Evidence for Central Nervous Effects of Corticotropin-Releasing Hormone on Gastric Acid Secretion in Humans

1997 • 29 citations

NGF and Alzheimer's: Hopes and Fears

1990 • 28 citations

Local Reduction of Organ Size in Transgenic Mice Expressing a Soluble Insulin-Like Growth Factor II/Mannose-6-Phosphate Receptor

1998 • 28 citations

Soluble insulin-like growth factor-II/mannose 6-P receptor inhibits deoxyribonucleic acid synthesis in cultured rat hepatocytes.

1996 • 25 citations

Comparative Binding of Neurotrophins (NT-3, CNTF and NGF) and Various Cytokines to α2-Macroglobulin

1993 • 24 citations

Circadian variation in serum free and total insulin-like growth factor (IGF)-I and IGF-II in untreated and treated acromegaly and growth hormone deficiency

2000 • 24 citations

Insulin-Like Growth Factors in the Brain

1993 • 23 citations

Concentration dependence of protein diffusion

1987 • 22 citations

Proteins I: Composition and Structure

2002 • 21 citations

Recommendations for Nomenclature of the Insulin-Like Growth Factor Binding Protein Superfamily

1998 • 20 citations

Peptide and Protein Drugs

1994 • 20 citations

Serum free insulin-like growth factor-I is dose-dependently decreased by methylprednisolone and related to body weight changes in rats

1999 • 19 citations

Interaction of [125I]? nerve growth factor with acidic proteins

1981 • 19 citations

Clinical Applications of Neurotrophic Factors

1997 • 18 citations

Enhanced delivery of [125I]glial cell line-derived neurotrophic factor to the rat CNS following osmotic blood-brain barrier modification

1996 • 18 citations

Physicochemical Characterization of Recombinant Human Nerve Growth Factor Produced in Insect Cells with a Baculovirus Vector

1991 • 18 citations

A fibroblast growth factor binding protein in human cerebral spinal fluid

1995 • 17 citations

Effect of hyperthyroidism on circulating levels of free and total IGF-I and IGFBPs in rats

1995 • 17 citations

Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum

1996 • 15 citations

Pharmacokinetic considerations of regional administration and drug targeting: Influence of site of input in target tissue and flux of binding protein

1996 • 14 citations

Developmental changes in nerve growth factor level in rat serum

1992 • 14 citations

A Compartmental Model for Simulation of IGF-I Kinetics and Metabolism

1994 • 13 citations

The effect of nasal patency on the clearance of radiolabeled saline in healthy volunteers.

2000 • 13 citations

CNTF II, I presume?

2000 • 13 citations

Effect of Recombinant Human Growth Hormone and Insulin‐Like Growth Factor‐1 Administration on IGF‐1 and IGF‐Binding Protein‐3 Levels in Brain Injury

1999 • 12 citations

Reversible sedimentation and masking of nerve growth factor (NGF) antigen by high molecular weight fractions from rat brain

1997 • 11 citations

Lay-offs follow suspension of clinical trials of protein

1994 • 11 citations

Nervous Excitement over Neurotrophic Factors

1995 • 11 citations

Stability and interactions of recombinant human nerve growth factor in different biological matrices: in vitro and in vivo studies.

2000 • 10 citations

Epidermal Growth Factor: Structure, Expression, and Functions in the Central Nervous System

1993 • 9 citations

Previously reported nerve growth factor levels are underestimated due to an incomplete release from receptors and interaction with standard curve media

1999 • 8 citations

Gene therapy to the rescue in Parkinson's disease

2001 • 5 citations

Separation and microanalysis of growth factors by Phast system gel electrophoresis and by DNA synthesis in cell culture

1991 • 5 citations

Epi-Arachnoidal Drug Deposit

1999 • 4 citations

Kidney as an important metabolic organ for recombinant human insulin-like growth factor-I.

1997 • 4 citations

Assessing Commercial Potential of Central Nervous System Delivery Approaches

1994 • 4 citations

The Effect of Route of Administration and Distribution on Drug Action

2002 • 3 citations

Strategies for Administering Neurotrophic Factors to the Central Nervous System

1999 • 1 citations

Propentofylline Prevents Neuronal Dysfunction Induced by Infusion of Anti-Nerve Growth Factor Antibody into the rat Septum.

1997 • 1 citations

Deleted Work

1955 • 0 citations