Identification of Two Novel Loci for Dominantly Inherited Familial Amyotrophic Lateral Sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

1994 • 2,090 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

1996 • 1,201 citations

Mutant dynactin in motor neuron disease

2003 • 933 citations

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

2002 • 822 citations

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

2001 • 722 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

2001 • 660 citations

Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease

2001 • 316 citations

Linkage of Familial Amyotrophic Lateral Sclerosis With Frontotemporal Dementia to Chromosome 9q21-q22

2000 • 316 citations

Estimating the power of a proposed linkage study for a complex genetic trait.

1989 • 236 citations

Familial amyotrophic lateral sclerosis

2002 • 231 citations

Construction of human linkage maps: Likelihood calculations for multilocus linkage analysis

1986 • 215 citations

A Novel Locus for Familial Amyotrophic Lateral Sclerosis, on Chromosome 18q

2002 • 138 citations