The Neuropilins Multifunctional Semaphorin and VEGF Receptors that Modulate Axon Guidance and Angiogenesis

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Neuropilin Is a Semaphorin III Receptor

1997 • 1,166 citations

Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

1993 • 1,146 citations

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

1997 • 1,131 citations

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

1999 • 1,118 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors

1999 • 803 citations

Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides

1998 • 784 citations

Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

1995 • 687 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Semaphorin 3A is a chemoattractant for cortical apical dendrites

2000 • 678 citations

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

1997 • 650 citations

Semaphorin III is needed for normal patterning and growth of nerves, bones and heart

1996 • 570 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility

1999 • 469 citations

Semaphorins and their receptors in vertebrates and invertebrates

2000 • 456 citations

Neuropilin-2 Is Required In Vivo for Selective Axon Guidance Responses to Secreted Semaphorins

2000 • 436 citations

Analysis of the L1-Deficient Mouse Phenotype Reveals Cross-Talk between Sema3A and L1 Signaling Pathways in Axonal Guidance

2000 • 423 citations

Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs

1995 • 412 citations

Neuropilin-2 and Neuropilin-1 Are Receptors for the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF) and of Placenta Growth Factor-2, but Only Neuropilin-2 Functions as a Receptor for the 145-Amino Acid Form of VEGF

2000 • 411 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

Neuropilin-2 Regulates the Development of Select Cranial and Sensory Nerves and Hippocampal Mossy Fiber Projections

2000 • 363 citations

Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain

1996 • 345 citations

A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System

1996 • 345 citations

Neuropilin-1 Is a Placenta Growth Factor-2 Receptor

1998 • 344 citations

Molecular basis of semaphorin-mediated axon guidance

2000 • 300 citations

Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor:In vivoexpression and antitumor activity

2000 • 299 citations

Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121

2001 • 298 citations

Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily

2000 • 290 citations

The interaction of Neuropilin-1 with Vascular Endothelial Growth Factor and its receptor Flt-1

2000 • 289 citations

Cloning and Characterization of Neuropilin-1-Interacting Protein: A PSD-95/Dlg/ZO-1 Domain-Containing Protein That Interacts with the Cytoplasmic Domain of Neuropilin-1

1999 • 282 citations

Enhancement of Tumor Growth and Vascular Density by Transfection of Vascular Endothelial Cell Growth Factor Into MCF-7 Human Breast Carcinoma Cells

1995 • 270 citations

Neuropilin-1 Extracellular Domains Mediate Semaphorin D/III-Induced Growth Cone Collapse

1998 • 269 citations

Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A

2000 • 242 citations

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

1998 • 232 citations

Semaphorin 3A–Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor

2001 • 227 citations

The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors

1991 • 224 citations

PlexinA1 Autoinhibition by the Plexin Sema Domain

2001 • 203 citations

Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms

1995 • 203 citations

Expression of a Cell Adhesion Molecule, Neuropilin, in the Developing Chick Nervous System

1995 • 200 citations

Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells

1996 • 200 citations

Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho

2001 • 187 citations

Genomic Organization of Human Neuropilin-1 and Neuropilin-2 Genes: Identification and Distribution of Splice Variants and Soluble Isoforms

2000 • 185 citations

Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors

1999 • 170 citations

Vascular Endothelial Growth Factor Receptor-1 and Neuropilin-2 Form Complexes

2001 • 148 citations

VEGF121Induces Proliferation of Vascular Endothelial Cells and Expression offlk-1without Affecting Lymphatic Vessels of the Chorioallantoic Membrane

1996 • 139 citations

Determination of Cell Adhesion Sites of Neuropilin-1

2000 • 108 citations

Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis

2001 • 71 citations

Growth-Associated Expression of a Membrane Protein, Neuropilin, in <i>Xenopus </i>Optic NerveFibers

1995 • 64 citations

A Dominant Negative Receptor for Specific Secreted Semaphorins Is Generated by Deleting an Extracellular Domain from Neuropilin-1

1999 • 63 citations

Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance

1998 • 54 citations

Effects of VEGF₁₆₅and VEGF₁₂₁on vasculogenesis and angiogenesis in cultured embryonic quail hearts

2001 • 50 citations

Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin

1999 • 47 citations