Vascular-specific growth factors and blood vessel formation

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Mechanisms of angiogenesis and arteriogenesis

2000 • 4,120 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1999 • 2,034 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

1999 • 1,618 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

1994 • 1,269 citations

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

1998 • 1,239 citations

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

1998 • 1,082 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

1999 • 1,019 citations

Clinical applications of angiogenic growth factors and their inhibitors

1999 • 1,017 citations

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1995 • 990 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

VEGF is required for growth and survival in neonatal mice

1999 • 901 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF

1999 • 751 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

1999 • 708 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

1998 • 552 citations

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

1999 • 542 citations

Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity

1996 • 498 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression

2000 • 423 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

A model of angiogenesis in the mouse cornea.

1996 • 411 citations

VEGF Gene Delivery to Muscle

1998 • 363 citations

Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact

1999 • 338 citations

Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

1997 • 330 citations

Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

2000 • 323 citations

Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity.

1996 • 319 citations

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1998 • 311 citations

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development

1998 • 232 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF)

1999 • 199 citations

The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis.

1996 • 194 citations

Current biology of VEGF-B and VEGF-C

1999 • 183 citations

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

1993 • 179 citations

Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors

1999 • 170 citations

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

1992 • 132 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme

1994 • 111 citations

Vascular Endothelial Growth Factor Receptor-3

1999 • 109 citations

Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trial

1998 • 49 citations

Results of Intracoronary Recombinant Human Vascular Endothelial Growth Factor (rhVEGF) Administration Trial

1998 • 22 citations