Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

1966 • 3,631 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

1994 • 2,954 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Biochemical, physiological and medical aspects of ubiquinone function

1995 • 1,210 citations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

A non-disruptive technique for loading calcium buffers and indicators into cells

1981 • 1,121 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

[Protein import into mitochondria].

2000 • 971 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Mitochondria and cell death

1999 • 763 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Mitochondrial control of apoptosis: the role of cytochrome c

1998 • 751 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences

1979 • 727 citations

Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum.

1986 • 710 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

1999 • 664 citations

Role of mitochondria in oxidative stress and ageing

1998 • 649 citations

Specific inhibition of mitochondrial Ca++ transport by ruthenium red

1971 • 616 citations

Mitochondrial dysfunction in neurodegenerative diseases

1998 • 606 citations

Ca++ Uptake by Rat Kidney Mitochondria and Its Dependence on Respiration and Phosphorylation

1962 • 606 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1998 • 568 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

The Energy-linked Reaction of Calcium with Mitochondria

1965 • 556 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

1994 • 494 citations

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1998 • 494 citations

Mitochondrial calcium transport

1982 • 486 citations

Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum.

1988 • 475 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers

1996 • 447 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

Stoichiometry of Respiratory Stimulation, Accumulation of Ca++ and Phosphate, and Oxidative Phosphorylation in Rat Liver Mitochondria

1964 • 441 citations

CALCIUM UPTAKE BY RAT KIDNEY MITOCHONDRIA

1961 • 439 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Energy‐Linked Ion Movements in Mitochondrial Systems

1967 • 403 citations

The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues

1978 • 402 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

Bcl-2 family proteins and mitochondria

1998 • 374 citations

Translocation of some Anions Cations and Acids in Rat Liver Mitochondria

1969 • 371 citations

Regulation of cell magnesium

1992 • 371 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Regulation of Ca ²⁺ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1978 • 364 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria.

1992 • 358 citations

The release of calcium from heart mitochondria by sodium

1974 • 353 citations

Dominant Role of Mitochondria in Clearance of Large Ca2+ Loads from Rat Adrenal Chromaffin Cells

1996 • 352 citations

The inhibition of mitochondrial calcium transport by lanthanides and Ruthenium Red

1974 • 351 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

The effect of ruthenium red on Ca2+ transport and respiration in rat liver mitochondria

1972 • 321 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

Mitochondrial calcium transport

1980 • 304 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

The osmotic behavior and permeability to non-electrolytes of mitochondria

1955 • 293 citations

Biochemical and Osmotic Properties of Skeletal Muscle Mitochondria

1954 • 289 citations

The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.

1980 • 288 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Transport of calcium by mitochondria

1994 • 276 citations

Imaging the Permeability Pore Transition in Single Mitochondria

1998 • 269 citations

The Calcium‐Induced and Sodium‐Induced Effluxes of Calcium from Heart Mitochondria

1977 • 265 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate

1998 • 257 citations

Identification of a Mitochondrial Na+/H+Exchanger

1998 • 256 citations

VDAC, a Channel in the Outer Mitochondrial Membrane

1996 • 252 citations

Intracellular Sequestration of Sodium by a Novel Na+/H+ Exchanger in Yeast Is Enhanced by Mutations in the Plasma Membrane H+-ATPase

1997 • 248 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Calcium uptake and membrane potential in mitochondria

1974 • 247 citations

A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

1998 • 246 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume.

1985 • 237 citations

Structure-activity relationships of K+ channel openers

1990 • 237 citations

Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicity

1990 • 234 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

The Steady State Maintenance of Accumulated Ca++ in Rat Liver Mitochondria

1965 • 232 citations

Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

1987 • 232 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria

1993 • 221 citations

Hydroperoxide-induced loss of pyridine nucleotides and release of calcium from rat liver mitochondria.

1980 • 220 citations

Ca2+-dependent mechanisms of cytotoxicity and programmed cell death

1992 • 220 citations

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1993 • 213 citations

Novel Localization of a Na+/H+ Exchanger in a Late Endosomal Compartment of Yeast

1998 • 212 citations

Mitochondrial dysfunction in neurodegenerative disorders

1998 • 211 citations

Evidence for more than one C²⁺ion transport mechanism in mitochondria

1976 • 211 citations

Physiological role of mitochondrial Ca2+ transport

1994 • 209 citations

Cation transport in mitochondria — The potassium cycle

1996 • 208 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

1995 • 207 citations

Mitochondrial channel activity studied by patch-clamping mitoplasts

1989 • 206 citations

Hydroperoxides can modulate the redox state of pyridine nucleotides and the calcium balance in rat liver mitochondria

1979 • 205 citations

Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors.

1992 • 202 citations

Subcellular metabolic transients and mitochondrial redox waves in heart cells

1998 • 201 citations

Calcium Ion Distribution in Cytoplasm Visualized by Aequorin: Diffusion in Cytosol Restricted by Energized Sequestering

1975 • 196 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

Mitochondrial function as a determinant of recovery or death in cell response to injury

1998 • 190 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

Intramitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmaleimide on mitochondrial function.

1979 • 189 citations

The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria

1978 • 188 citations

Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

1995 • 187 citations

Regulation of Citric Acid Cycle by Calcium

1989 • 187 citations

Involvement of the ADPATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: Importance of the orientation of the nucleotide binding site

1988 • 186 citations

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.

1993 • 182 citations

The Initial Velocities of Calcium Uptake by Rat Liver Mitochondria

1973 • 182 citations

Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

1979 • 182 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

Spermine. A regulator of mitochondrial calcium cycling.

1984 • 181 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

Mitochondria and neuronal glutamate excitotoxicity

1998 • 178 citations

Some observations on the photometric estimation of mitochondrial volume

1958 • 175 citations

Molecular Cloning of Aralar, a New Member of the Mitochondrial Carrier Superfamily That Binds Calcium and Is Present in Human Muscle and Brain

1998 • 172 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 172 citations

Inhibition and activation of calcium transport in mitochondria. Effect of lanthanides and local anesthetic drugs

1969 • 170 citations

A heart mitochondrial Ca2+-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states

1990 • 168 citations

The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients

1998 • 165 citations

Ionophore A23187: the effect of proton concentration on complex formation with divalent and monovalent cations and the demonstration of potassium(1+) ion transport in mitochondria mediated by A23187

1976 • 163 citations

The Mechanism of Ion Translocation in Mitochondria. 4. Coupling of K+ Efflux with Ca2+ Uptake

1970 • 163 citations

Inhibition of mitochondrial calcium ion transport by an oxo-bridged dinuclear ruthenium ammine complex

1991 • 163 citations

Control of Hepatic Mitochondrial CO2 Fixation by Glucagon, Epinephrine, and Cortisol

1969 • 163 citations

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

1980 • 161 citations

Mitochondria in neuromuscular disorders

1998 • 161 citations

On the mechanism of regulation of the mitochondrial K+/H+ exchanger.

1980 • 160 citations

Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria.

1985 • 160 citations

Calcium transport in mitochondria

1970 • 158 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

1998 • 152 citations

Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

1994 • 149 citations

Untitled

1998 • 146 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Kinetics of calcium(2+) ion carrier in rat liver mitochondria

1979 • 143 citations

Ion Transport by Heart Mitochondria

1970 • 142 citations

The Sodium-Calcium Antiport of Heart Mitochondria Is Not Electroneutral

1995 • 142 citations

Mitochondrial Calcium Transport

1977 • 139 citations

Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations.

1994 • 139 citations

The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient

1976 • 139 citations

Pyridine‐nucleotide oxidation, Ca²⁺ cycling and membrane damage during tert‐butyl hydroperoxide metabolism by rat‐liver mitochondria

1984 • 135 citations

Determination of the Proton Electrochemical Gradient across Biological Membranes

1984 • 134 citations

Reconsidering mitochondrial structure: new views of an old organelle

1997 • 130 citations

Calcium and pyridine nucleotide interaction in mitochondrial membranes

1972 • 128 citations

The role of calcium in lethal cell injury

1990 • 128 citations

Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases

1998 • 126 citations

Isolation of a soluble Ca2+ binding glycoprotein from ox liver mitochondria

1972 • 125 citations

The role of mitochondria in the salvage and the injury of the ischemic myocardium

1998 • 125 citations

The Role of Phosphate in the Regulation of the Independent Calcium‐Efflux Pathway of Liver Mitochondria

1982 • 124 citations

Spermine Inhibition of the Permeability Transition of Isolated Rat Liver Mitochondria: An Investigation of Mechanism

1993 • 124 citations

Channels in Mitochondrial Membranes: Knowns, Unknowns, and Prospects for the Future

1993 • 123 citations

A Kinetic Study of Mitochondrial Calcium Transport

1975 • 120 citations

Mitochondrial metabolite transporters

1996 • 120 citations

Disequilibrium between steady-state Ca²⁺ ion accumulation ratio and membrane potential in mitochondria. Pathway and role of Ca²⁺ ion efflux

1977 • 118 citations

Swelling and contraction of the mitochondrial matrix. II. Quantitative application of the light scattering technique to solute transport across the inner membrane.

1985 • 114 citations

Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism

1998 • 111 citations

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1988 • 110 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

Increased permeability of mitochondria during Ca2+ release induced by t-butyl hydroperoxide or oxalacetate. the effect of ruthenium red.

1982 • 109 citations

Kinetics of mitochondrial calcium transport. II. A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium.

1986 • 106 citations

Translocation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline

1995 • 106 citations

The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage

1972 • 106 citations

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

1996 • 105 citations

On the regulation of K+ uniport in intact mitochondria by adenine nucleotides and nucleotide analogs.

1993 • 104 citations

Quinine inhibition of Na+ and K+ transport provides evidence for two cation/H+ exchangers in rat liver mitochondria.

1982 • 103 citations

Studies on mitochondrial Ca2+-transportand matrix Ca2+ using fura-2-loaded rat heart mitochondria

1989 • 103 citations

Inhibition of the Mitochondrial KATP Channel by Long-chain Acyl-CoA Esters and Activation by Guanine Nucleotides

1996 • 103 citations

The Regulation of Mitochondrial Calcium Transport in Heart

1985 • 102 citations

Energy Dependent Bivalent Cation Translocation in Rat Liver Mitochondria

1970 • 99 citations

Imaging the mitochondrial permeability transition pore in intact cells

1998 • 98 citations

Regulation of the mitochondrial matrix volume in vivo and in vitro. The role of calcium

1986 • 97 citations

Stimulation of mitochondrial calcium ion efflux by thiol-specific reagents and by thyroxine. The relationship to adenosine diphosphate retention and to mitochondrial permeability

1979 • 96 citations

Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition

1997 • 95 citations

The control of Ca2+ release from heart mitochondria.

1981 • 95 citations

The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides

1980 • 94 citations

Maintenance of Energy-Linked Functions in Rat-Liver Mitochondria Aged in the Presence of Nupercaine

1972 • 94 citations

Changes in mitochondrial calcium concentration during the cardiac contraction cycle

1993 • 94 citations

On the Relationship between Rate of ATP Synthesis and H⁺ Electrochemical Gradient in Rat‐Liver Mitochondria

1982 • 93 citations

The mitochondrial permeability transition. Interactions of spermine, ADP, and inorganic phosphate.

1994 • 93 citations

Regulation of the Mitochondrial Ca²⁺ Uniporter by External Adenine Nucleotides: The Uniporter Behaves Like a Gated Channel Which Is Regulated by Nucleotides and Divalent Cations

1997 • 92 citations

Ion transport in heart mitochondria. XIII. The effect of ethylenediaminetetraacetate on monovalent ion uptake

1968 • 92 citations

Mechanism of respiration-driven proton translocation in the inner mitochondrial membrane. Kinetics of proton translocation and role of cations

1973 • 90 citations

Mitochondrial Cation-Hydrogen Ion Exchange

1974 • 89 citations

Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane

1978 • 89 citations

Induction of the mitochondrial permeability transition by N-ethylmaleimide depends on secondary oxidation of critical thiol groups. Potentiation by copper-ortho-phenanthroline without dimerization of the adenine nucleotide translocase

1998 • 87 citations

Selective inhibition of the mitochondrial permeability transition pore at the oxidation‐reduction sensitive dithiol by monobromobimane

1995 • 85 citations

On the mechanism of A23187-induced potassium efflux in rat liver mitochondria.

1980 • 84 citations

EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane.

1988 • 81 citations

Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria.

1992 • 81 citations

Regulation of Ca²⁺ Efflux in Rat Liver Mitochondria

1983 • 80 citations

Cation transport systems in mitochondria: Na+ and K+ uniports and exchangers

1994 • 79 citations

Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

1996 • 79 citations

Immunochemical characterization of the adenine nucleotide translocator

1984 • 77 citations

Conversion of esterified fura-2 and indo-1 to Ca2+-sensitive forms by mitochondria

1988 • 77 citations

Electroneutral H+-K+ exchange in liver mitochondria Regulation by membrane potential

1983 • 76 citations

Na(+)-dependent Ca2+ efflux mechanism of heart mitochondria is not a passive Ca2+/2Na+ exchanger

1994 • 75 citations

Proton electrochemical potential in steady state rat liver mitochondria

1977 • 75 citations

Structural basis of ion channel permeation and selectivity

1994 • 75 citations

Cyclic AMP-induced Mg2+ release from rat liver hepatocytes, permeabilized hepatocytes, and isolated mitochondria.

1991 • 75 citations

On the mechanism by which dicyclohexylcarbodiimide and quinine inhibit K+ transport in rat liver mitochondria.

1986 • 75 citations

Manganous Ion as a Spin Label in Studies of Mitochondrial Uptake of Manganese

1972 • 74 citations

Mg2+ and the permeability of heart mitochondria to monovalent cations

1976 • 74 citations

Na⁺ releases Ca²⁺ from liver, kidney and lung mitochondria

1980 • 74 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Electric charge stoichiometry of calcium translocation in mitochondria

1977 • 74 citations

cDNA cloning of rat mitochondrial cyclophilin

1997 • 73 citations

Ca2+ ions, an allosteric activator of calcium uptake in rat liver mitochondria

1986 • 73 citations

Kinetics of mitochondrial calcium transport. I. Characteristics of the sodium-independent calcium efflux mechanism of liver mitochondria.

1986 • 72 citations

On the inter-relationship between glucagon action, the oxidation-reduction state of pyridine nucleotides, and calcium retention by rat liver mitochondria.

1980 • 71 citations

Electric charge stoicheiometry of calcium translocation in rat liver mitochondria

1977 • 70 citations

The Mitochondrial Sulfonylurea Receptor: Identification and Characterization

1997 • 69 citations

Permeability to water, dimension of surface, and structural changes during swelling in rat liver mitochondria

1972 • 68 citations

The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter

1985 • 68 citations

The participation of NADP, the transmembrane potential and the energy-linked NAD(P) transhydrogenase in the process of Ca2+ efflux from rat liver mitochondria

1987 • 66 citations

Thermodynamic and Kinetic Aspects of the Interconversion of Chemical and Osmotic Energies in Mitochondria

1971 • 66 citations

Effect of Mg2+ depletion of mitochondria on their permeability to K+: The mechanism by which ionophore A23187 increases K+ permeability

1977 • 65 citations

Relationships between Ca2+ release, Ca2+ cycling, and Ca2+-mediated permeability changes in mitochondria.

1985 • 65 citations

Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin

1997 • 65 citations

Activation of mitochondrial oxidative metabolism by calcium ions in Limulusventral photoreceptor

1988 • 65 citations

Stimulation by α-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver

1983 • 65 citations

Ruthenium red sensitive and insensitive calcium transport in rat liver and Ehrlich ascites tumor cell mitochondria

1978 • 62 citations

Distribution of permeant cations in rat liver mitochondria under steady-state conditions

1972 • 62 citations

The mechanism of mitochondrial swelling

1969 • 62 citations

Osmotic swelling of heart mitochondria in acetate and chloride salts

1978 • 62 citations

Pathways for Ca2+ efflux in heart and liver mitochondria

1987 • 61 citations

Energy-linked Ion Translocation in Submitochondrial Particles

1969 • 61 citations

Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by Ruthenium Red

1984 • 60 citations

Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger

1988 • 60 citations

Mitochondria, glutamate neurotoxicity and the death cascade

1998 • 59 citations

Volume changes in liver mitochondria.

1965 • 57 citations

Effect of inhibitors on the sigmoidicity of the calcium ion transport kinetics in rat liver mitochondria

1977 • 56 citations

Manganese stimulates calcium flux through the mitochondrial uniporter

1985 • 56 citations

Potassium Channel Opener, RP 66471, Induces Membrane Depolarization of Rat Liver Mitochondria

1995 • 56 citations

Swelling and Shrinkage Phenomena in Liver Mitochondria

1966 • 55 citations

Intramitochondrial free calcium in cardiac myocytes in relation to dehydrogenase activation

1993 • 55 citations

Unmasking the mitochondrial KH exchanger: Swelling-induced K+-loss

1978 • 55 citations

Untitled

1997 • 54 citations

Efflux of Ca²⁺andMn²⁺ from rat liver mitochondria

1978 • 53 citations

On the relative roles of Ca2+ and Mg2+ in regulating the endogenous K+/H+ exchanger of rat liver mitochondria.

1982 • 53 citations

Active accumulation of Sr2+ by rat-liver mitochondria II. Competition between Ca2+ and Sr2+

1965 • 53 citations

Spatial heterogeneity of intracellular Ca2+ concentration in nonbeating guinea pig ventricular myocytes.

1990 • 53 citations

Dissociation of NAD(P)+-stimulated mitochondrial Ca2+ efflux from swelling and membrane damage

1984 • 52 citations

Regulation of the mitochondrial Na+Ca2+ antiport by matrix pH

1991 • 52 citations

The Mitochondrial Uncoupling Protein: Structural and Genetic Studies

1997 • 52 citations

Mechanism of sodium ion independent calcium ion efflux from rat liver mitochondria

1983 • 52 citations

Structure-function relationships of the ADP/ATP carrier

1994 • 52 citations

Chemical Modification of Arginines by 2,3-Butanedione and Phenylglyoxal Causes Closure of the Mitochondrial Permeability Transition Pore

1998 • 51 citations

The Ca2+-Na+ antiporter of heart mitochondria operates electroneutrally

1980 • 51 citations

The Na(+)-independent Ca2+ efflux mechanism of liver mitochondria is not a passive Ca2+/2H+ exchanger.

1991 • 51 citations

Purification of a reconstitutively active K+/H+ antiporter from rat liver mitochondria.

1990 • 50 citations

Induction of electroneutral exchanges of H⁺ with K⁺ in rat liver mitochondria

1978 • 50 citations

Ruthenium red-sensitive and -insensitive release of Ca2+ from uncoupled heart mitochondria

1983 • 49 citations

The Role of Mitochondrial Potassium Fluxes in Controlling the Protonmotive Force in Energized Mitochondria

1995 • 49 citations

Sodium-induced calcium release from mitochondria in brown adipose tissue.

1979 • 48 citations

Mitochondrial cation transport: A progress report

1994 • 48 citations

Inhibition of the mitochondrial Ca2+ uniporter by pure and impure ruthenium red

1994 • 48 citations

A membrane potential‐modulated pathway for Ca²⁺ efflux in rat liver mitochondria

1982 • 47 citations

A re-evaluation of the role of mitochondrial pyruvate transport in the hormonal control of rat liver mitochondrial pyruvate metabolism

1984 • 47 citations

Dissociation between mitochondria calcium ion release and pyridine nucleotide oxidation.

1980 • 46 citations

Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters

1993 • 46 citations

Reconstitution and partial purification of the Na(+)-selective Na+/H+ antiporter of beef heart mitochondria.

1991 • 45 citations

Unmasking the mitochondrial KH exchanger: Tetraethylammonium-induced K+-loss

1979 • 45 citations

H⁺/site ratio and steady state distribution of divalent cations in mitochondria

1977 • 44 citations

Inhibition of Na⁺‐dependent Ca²⁺ efflux from heart mitochondria by amiloride analogues

1983 • 44 citations

A comparison of the effects of different divalent cations on a number of mitochondrial reactions linked to ion translocation

1969 • 43 citations

Kinetic Analysis of the Mitochondrial Permeability Transition

1996 • 43 citations

Ion transport by heart mitochondria. XVIII. Swelling and contraction of heart mitochondria suspended in ammonium chloride

1970 • 43 citations

Separate pathways for Ca²⁺ uptake and release in liver mitochondria

1978 • 43 citations

Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells.

1994 • 43 citations

Activation of Latent K+ Uniport in Mitochondria Treated with the Ionophore A23187

1989 • 42 citations

The Ca2+-induced permeability transition pore is involved in Ca2+-induced mitochondrial oscillations

1994 • 40 citations

A quantitative correlation between the kinetics of solutes and water translocation in Liver Mitochondria

1972 • 40 citations

Mitochondrial transport of K+ and Mg2+

1987 • 39 citations

K⁺ Fluxes and the mitochondrial membrane potential

1975 • 39 citations

Effect of Ca2+, peroxides, SH reagents, phosphate and aging on the permeability of mitochondrial membranes

1987 • 39 citations

Mechanism of active shrinkage in mitochondria I. Coupling between weak electrolyte fluxes

1976 • 39 citations

Spermine, another specific allosteric activator of calcium uptake in rat liver mitochondria

1988 • 38 citations

Sodium-calcium exchange in dog heart mitochondria: effects of ischemia and verapamil

1983 • 38 citations

Magnesium transport by mitochondria

1994 • 38 citations

Induction of respiration-dependent net efflux of K+ from heart mitochondria by depletion of endogenous divalent cations.

1980 • 38 citations

Intracellular targets for antidiabetic sulfonylureas and potassium channel openers

1997 • 38 citations

The activation of Na+-dependent efflux of Ca2+ from liver mitochondria by glucagon and β-adrenergic agonists

1983 • 38 citations

Submitochondrial localization of the NAD+ glycohydrolase. Implications for the role of pyridine nucleotide hydrolysis in mitochondrial calcium fluxes.

1993 • 37 citations

Mitochondrial Volume Control

1988 • 37 citations

The K+ conductance of the inner mitochondrial membrane. A study of the inducible uniport for monovalent cations

1991 • 37 citations

Mechanism of active shrinkage in mitochondria II. Coupling between strong electrolyte fluxes

1976 • 37 citations

Calcium ion cycling in rat liver mitochondria

1978 • 36 citations

Effect of Polycation Peptides on Mitochondrial Permeability Transition

1995 • 36 citations

Stimulation of calcium-ion efflux from liver mitochondria by sodium ions and its response to ADP and energy state

1981 • 35 citations

Purification of the channel component of the mitochondrial calcium uniporter and its reconstitution into planar lipid bilayers

1994 • 35 citations

The Ba2+ sensitivity of the Na+-induced Ca2+ efflux in heart mitochondria: the site of inhibitory action

1986 • 33 citations

t-Butylhydroperoxide-induced Ca2+ efflux from liver mitochondria in the presence of physiological concentrations of Mg2+ and ATP

1986 • 32 citations

On the nature of P_i‐induced, Mg²⁺‐prevented Ca²⁺ release in rat liver mitochondria

1982 • 32 citations

Evidence for the allosteric regulation of the mitochondrial K+/H+ antiporter by matrix protons.

1990 • 31 citations

Is the mitochondrial Ca²⁺ uniporter a voltage‐modulated transport pathway?

1991 • 31 citations

ΔpH Induced Calcium Fluxes in Rat Liver Mitochondria

1979 • 30 citations

Kinetic properties of the potassium/hydrogen ion antiport of heart mitochondria

1990 • 30 citations

Mg²⁺ restores membrane potential in rat liver mitochondria deenergized by Ca²⁺ and phosphate movements

1982 • 29 citations

Effect of micromolar concentrations of manganese ions on calcium-ion cycling in rat liver mitochondria

1983 • 29 citations

Kinetic properties of the sodium/hydrogen ion antiport of heart mitochondria

1989 • 29 citations

On the Relationship between Calcium and Phosphate Transport, Transmembrane Potential and Acetoacetate-Induced Oxidation of Pyridine Nucleotides in Rat-Liver Mitochondria

1983 • 28 citations

Stereospecific action of diltiazem on the mitochondrial NaCa exchange system and on sarcolemmal Ca-channels

1987 • 28 citations

Amiloride and diltiazem inhibition of microsomal and mitochondrial Na+ and Ca2+ transport

1984 • 28 citations

Energy-linked Ion Translocation in Submitochondrial Particles

1973 • 27 citations

Ca²⁺‐dependent inhibition by trifluoperazine of the Na⁺‐Ca²⁺ carrier in mitoplasts derived from heart mitochondria

1985 • 27 citations

[8] Calcium ion transport in mitochondria

1989 • 26 citations

Glibenclamide inhibits mitochondrial K+ and Na+ uniports induced by magnesium depletion

1996 • 26 citations

The Na⁺‐independent Ca²⁺ efflux system in mitochondria is a Ca²⁺/2H⁺ exchange system

1990 • 26 citations

The effects of Mg2+ and adenine nucleotides on the sensitivity of the heart mitochondrial Na+-Ca2+ carrier to extramitochondrial Ca2+. A study using arsenazo III-loaded mitochondria

1987 • 25 citations

Ruthenium red inhibits mitochondrial Na+ and K+ uniports induced by magnesium removal.

1990 • 25 citations

Ca2+ Transport against its electrochemical gradient in cytochrome oxidase vesicles reconstituted with mitochondrial hydrophobic proteins

1981 • 25 citations

Comparison of effects of glucagon and valinomycin on rat liver mitochondria and cells.

1974 • 24 citations

A gated pathway for electrophoretic Na⁺ fluxes in rat liver mitochondria

1990 • 23 citations

Effects of Monovalent Cations on Ca(2+) Transport in Mitochondria; A Comparison between Brown Fat and Liver Mitochondria from Rat.

1980 • 22 citations

A System for Producing and Monitoring in Vitro Calcium Pulses Similar to Those Observed in Vivo

1994 • 22 citations

Inhibition by Sr2+ of specific mitochondrial Ca2+-efflux pathways

1983 • 22 citations

Effect of ruthenium red on calcium efflux from rat liver mitochondria

1980 • 21 citations

Demonstration of glibenclamide-sensitive K+ fluxes in rat liver mitochondria.

1993 • 21 citations

Induction of electroneutral exchanges of H⁺ with Na⁺, divalent and organic cations in rat liver mitochondria

1978 • 20 citations

Mitochondrial oscillation and activation of H+/cation exchange

1982 • 20 citations

Ba2+ ions inhibit the release of Ca2+ ions from rat liver mitochondria

1985 • 19 citations

Evidence against norepinephrine-stimulated efflux of mitochondrial Mg2+ from intact cardiac myocytes

1994 • 15 citations

Rapid efflux of Ca2+ from heart mitochondria in the presence of inorganic pyrophosphate

1984 • 14 citations

Regulation of mitochondrial K+H+ antiport activity by hydrogen ions

1991 • 13 citations

Inhibition of brain mitochondrial Ca2+ transport by amiloride analogues

1985 • 13 citations

The effect of alkanols on Ca2+ transport in brain mitochondria

1992 • 12 citations

Characterization of calciphorin, the low molecular weight calciu, ionophore, from rat liver mitochondria

1984 • 11 citations

Uptake, retention, and efflux of Ca2+ by mitochondrial preparations from skeletal muscle

1984 • 9 citations

Identification of a 20-kDa protein with calcium uptake transport activity. Reconstitution in a membrane model

1994 • 9 citations

cAMP control of Mg2+ homeostasis in heart and liver cells.

1992 • 9 citations

Mitochondrial channels revisited

1996 • 8 citations

Guanidine derivative U-37883A, inhibits mitochondrial K+ uniport.

1995 • 8 citations

Non-respiring Rat Liver Mitochondria Do Not Have a Ca2+/2H+ Antiporter.

1987 • 8 citations

Effects of inhibitors and activators of ATP-regulated K+ channel on mitochondrial potassium uniport.

1996 • 7 citations

Inhibition of the Na+/Ca2+ antiport of heart mitochondria by diethylpyrocarbonate

1987 • 7 citations

Detection and Localization of Synexin (Annexin VII) in Xenopus Adult and Embryonic Tissues Using an Antibody to the Xenopus N-terminal PGQM Repeat Domain

1996 • 5 citations