Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

1987 • 332 citations

Cyclosporin A slows collagen triple-helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans-isomerase.

1991 • 313 citations

Prolyl Isomerase: Enzymatic Catalysis of Slow Protein-Folding Reactions

1993 • 307 citations

Immunophilins in protein folding and immunosuppression ¹

1994 • 247 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Peptidylproline cis/trans isomerases

1995 • 235 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Complex structure of quisqualate-sensitive glutamate receptors in rat cortex

1985 • 216 citations

The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)

1993 • 192 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

1991 • 187 citations

The ADP-ATP Carrier in Mitochondrial Membranes

1976 • 181 citations

Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum

1991 • 168 citations

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1991 • 149 citations

Electrophysiology of the inner mitochondrial membrane

1994 • 147 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Isolation and characterization of a 40-kDa cyclophilin-related protein.

1992 • 125 citations

Chaotropic Ions Affect the Conformation of Quisqualate Receptors in Rat Cortical Membranes

1988 • 123 citations

On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter

1994 • 46 citations

The intramitochondrial volume measured using sucrose as an extramitochondrial marker overestimates the true matrix volume determined with mannitol

1983 • 44 citations

Evidence for the Involvement of a Membrane-Associated Cyclosporin-A-Binding Protein in the Ca2+-Activated Inner Membrane Pore of Heart Mitochondria

1995 • 38 citations

An ADP‐sensitive cyclosporin‐A‐binding protein in rat liver mitochondria

1994 • 36 citations

Diazotization and Thiocyanate Differentiate Agonists from Antagonists for the High‐ and Low‐Affinity Receptors of γ‐Aminobutyric Acid

1984 • 26 citations

Ca²⁺‐triggered membrane permeability transition in deenergized mitochondria from rat liver

1995 • 23 citations

Further characterization of the acid-soluble phosphoprotein (SDS/PAGE apparent molecular mass of 22 kDa) in rat fat-cells by peptide sequencing and immuno-analysis: effects of insulin and isoprenaline

1995 • 20 citations

Effects of chaotropic agents versus detergents on dihydroorotate dehydrogenase.

1977 • 13 citations