Identification of a Mitochondrial Na+/H+Exchanger

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure

1995 • 2,001 citations

A knowledge base for predicting protein localization sites in eukaryotic cells

1992 • 1,518 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

A simple and efficient method for direct gene deletion inSaccharomyces cerevisiae

1993 • 1,256 citations

Improved Green Fluorescent Protein by Molecular Evolution Using DNA Shuffling

1996 • 1,212 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Molecular physiology of vertebrate Na+/H+ exchangers

1997 • 624 citations

Stationary phase in the yeast Saccharomyces cerevisiae

1993 • 594 citations

Na+/H+ Exchangers of Mammalian Cells

1997 • 586 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes.

1985 • 506 citations

The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues

1978 • 402 citations

Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast

1996 • 377 citations

Translocation of some Anions Cations and Acids in Rat Liver Mitochondria

1969 • 371 citations

The development of mitochondrial medicine.

1994 • 296 citations

Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger

1993 • 267 citations

The Protein Import System of Mitochondria

1996 • 261 citations

Intracellular Sequestration of Sodium by a Novel Na+/H+ Exchanger in Yeast Is Enhanced by Mutations in the Plasma Membrane H+-ATPase

1997 • 248 citations

Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification

1995 • 243 citations

Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells.

1995 • 240 citations

The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria

1978 • 188 citations

Characterization of the NHA1 gene encoding a Na⁺/H⁺‐antiporter of the yeast Saccharomyces cerevisiae

1996 • 170 citations

Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

1992 • 168 citations

Integration of Mitochondrial Function

1988 • 165 citations

Structure/function studies of mammalian Na‐H exchangers‐‐an update.

1995 • 162 citations

[43] Analysis of mitochondrial function and assembly

1991 • 159 citations

Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.

1992 • 158 citations

Identification of Sites Required for Down-regulation of Na+/H+ Exchanger NHE3 Activity by cAMP-dependent Protein Kinase

1997 • 148 citations

Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.

1993 • 138 citations

Properties of a Cyclosporin-insensitive Permeability Transition Pore in Yeast Mitochondria

1997 • 132 citations

The Na+/H+ Exchanger NHE-1 Possesses N- and O-Linked Glycosylation Restricted to the First N-Terminal Extracellular Domain

1994 • 126 citations

Ca2+ metabolism in yeast cells and mitochondria

1970 • 107 citations

Regulation of oxidative phosphorylation in mitochondria by external free Ca2+ concentrations.

1985 • 94 citations

Transmembrane gradients of free Na+ in isolated heart mitochondria estimated using a fluorescent probe

1992 • 92 citations

The cloning and DNA sequence of the gene for the glutathione‐regulated potassium‐efflux system KefC of Escherichia coli

1991 • 89 citations

Cation transport systems in mitochondria: Na+ and K+ uniports and exchangers

1994 • 79 citations

The plasma membrane Na+/H+ exchanger 2 is an O-linked but not an N-linked sialoglycoprotein: Use of a polyclonal antibody to identify and characterize glycosylation

1994 • 77 citations

Identification of an 82,000-dalton protein responsible for K+/H+ antiport in rat liver mitochondria.

1984 • 73 citations

K+/H+ antiport in heart mitochondria.

1984 • 71 citations

Localization of catalytic and regulatory subunits of cyclic AMP-dependent protein kinases in mitochondria from various rat tissues

1990 • 66 citations

Effects of Na+/H+ antiport and intracellular pH in the regulation of HL-60 cell apoptosis

1995 • 60 citations

[54] Analysis of chromosome segregation in Saccharomyces cerevisiae

1991 • 57 citations

Unmasking the mitochondrial KH exchanger: Swelling-induced K+-loss

1978 • 55 citations

[24] Mitochondrial cation transport systems

1995 • 45 citations

Reconstitution and partial purification of the Na(+)-selective Na+/H+ antiporter of beef heart mitochondria.

1991 • 45 citations

Calcium-binding ATPase inhibitor protein of bovine heart mitochondria. Role in ATP synthesis and effect of calcium

1989 • 39 citations

Characterization of the mitochondrial Na+H+ exchange. The effect of amiloride analogues

1988 • 36 citations

Purification and properties of a protamine kinase and a type II casein kinase from bovine kidney mitochondria

1988 • 36 citations

Evidence for three different electrophoretic pathways in yeast mitochondria: Ion specificity and inhibitor sensitivity

1993 • 33 citations

Evidence for the allosteric regulation of the mitochondrial K+/H+ antiporter by matrix protons.

1990 • 31 citations

Inhibition of oxidative phosphorylation by a Ca2+-induced diminution of the adenine nucleotide translocator

1983 • 31 citations

Embryonic chick allantois: functional isolation and development of sodium transport

1986 • 29 citations

Kinetic properties of the sodium/hydrogen ion antiport of heart mitochondria

1989 • 29 citations

On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: Evidence for the absence of an Na+-selective Na+/H+ antiporter

1993 • 28 citations

K+/H+ exchange in yeast mitochondria: sensitivity to inhibitors, solubilization and reconstitution of the activity in proteoliposomes

1992 • 22 citations

The Na+/H+ antiport in renal mitochondria

1995 • 11 citations

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