Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Calcium signaling

1995 • 1,905 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

1992 • 1,144 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Control of respiration and ATP synthesis in mammalian mitochondria and cells

1992 • 598 citations

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

1989 • 596 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

1997 • 513 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Spatial and temporal aspects of cellular calcium signaling

1996 • 480 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Regulation of oxidative phosphorylation in the mammalian cell

1990 • 432 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

Characterization of Cytosolic Calcium Oscillations Induced by Phenylephrine and Vasopressin in Single Fura-2-loaded Hepatocytes

1989 • 369 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1992 • 336 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

Calcium Spiking

1991 • 317 citations

Mechanisms and function of intercellular calcium signaling

1994 • 305 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i

1994 • 262 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria

1993 • 221 citations

Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes.

1990 • 220 citations

Coordination of Ca2+ Signaling by Intercellular Propagation of Ca2+ Waves in the Intact Liver

1995 • 220 citations

Physiological role of mitochondrial Ca2+ transport

1994 • 209 citations

Calcium oscillations in electrically non-excitable cells

1990 • 191 citations

Dynamic pacing of cell metabolism by intracellular Ca2+ transients.

1994 • 185 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

A Role for Calcium Influx in the Regulation of Mitochondrial Calcium in Endothelial Cells

1996 • 183 citations

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells

1997 • 183 citations

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.

1993 • 182 citations

Control of respiration and oxidative phosphorylation in isolated rat liver cells

1990 • 171 citations

Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist

1997 • 148 citations

Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells.

1996 • 144 citations

Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations.

1994 • 139 citations

Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells.

1992 • 104 citations

Stimulation of K-C1 cotransport in rat red cells by a hemolytic anemia-producing metabolite of dapsone

1989 • 101 citations

Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with α-adrenergic agonists and with glucagon

1980 • 93 citations

Changes in pyridine nucleotide levels alter oxygen consumption and extra-mitochondrial phosphates in isolated mitochondria: A 31P-NMR and NAD(P)H fluorescence study

1987 • 90 citations

Intercellular calcium waves in rat pancreatic acini: mechanism of transmission

1996 • 90 citations

Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin

1983 • 89 citations

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

1985 • 84 citations

Luminal communication between intracellular calcium stores modulated by GTP and the cytoskeleton.

1994 • 84 citations

Intracellular calcium waves generated by ins(1,4,5)P3-dependent mechanisms

1993 • 83 citations

Hormone-induced changes in NADH fluorescence and O2 consumption of rat hepatocytes

1982 • 75 citations

The hormonal regulation of pyruvate dehydrogenase complex

1996 • 75 citations

Ca2+ ions, an allosteric activator of calcium uptake in rat liver mitochondria

1986 • 73 citations

3 Pyruvate Dehydrogenase

1987 • 69 citations

Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content

1987 • 68 citations

The mechanism of the hormonal activation of respiration in isolated hepatocytes and its importance in the regulation of gluconeogenesis

1986 • 64 citations

Submicromolar Ca2+ regulates phosphorylating respiration by normal rat liver and AS-30D hepatoma mitochondria by different mechanisms.

1990 • 55 citations

The effect of hormones on proton compartmentation in hepatocytes.

1984 • 54 citations

The Ca2+-mobilizing actions of vasopressin and angiotensin differ from those of the α-adrenergic agonist phenylephrine in the perfused rat liver

1985 • 53 citations

Ca2+ binding to citrate cycle dehydrogenases

1990 • 50 citations

Glucagon treatment stimulates the metabolism of hepatic submitochondrial particles.

1978 • 40 citations

Effects of Calcium Ions on the Activation of Gluconeogenesis by Norepinephrine in Perfused Rat Liver

1980 • 34 citations

Control of oxidative phosphorylation in mitochondria, cells and tissues

1991 • 32 citations

α-adrenergic stimulation of respiration in isolated rat hepatocytes

1983 • 31 citations

Control of energy metabolism by glucagon and adrenaline in perfused rat liver

1986 • 29 citations

“Allosteric Regulation” of Calcium-Uptake in Rat Liver Mitochondria

1986 • 26 citations

Inhibition by Ca2+ of the hydrolysis and the synthesis of ATP in Ehrlich ascites tumour mitochondria: relation to the Crabtree effect

1995 • 22 citations

Continuous measurement of mitochondrial pH gradients in isolated hepatocytes by difference ratio spectroscopy

1991 • 17 citations

Spatial organization of oscillating calcium signals in liver

1995 • 16 citations

[11] Effects of hormones on mitochondrial processes

1989 • 11 citations

Chapter 18 Hormonal regulation of cellular energy metabolism

1992 • 5 citations