Intracellular targets for antidiabetic sulfonylureas and potassium channel openers

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

The Pharmacology of ATP-Sensitive Potassium Channels

1993 • 530 citations

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers

1996 • 447 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria.

1992 • 358 citations

The sulfonylurea receptor

1992 • 257 citations

Structure-activity relationships of K+ channel openers

1990 • 237 citations

Cation transport in mitochondria — The potassium cycle

1996 • 208 citations

PKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic β Cells

1996 • 196 citations

Regulation of mitochondrial metabolism through changes in matrix volume

1994 • 118 citations

Sulphonylurea Antidiabetic Drugs

1989 • 108 citations

The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

1992 • 72 citations

Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells

1995 • 72 citations

ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

1993 • 64 citations

Internalization of 3H-glibenclamide in pancreatic islet cells

1986 • 63 citations

Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide.

1995 • 59 citations

Pancreatic and Extrapancreatic Sulfonylurea Receptors

1992 • 59 citations

ATP-Sensitive Potassium Channels

1994 • 58 citations

Potassium Channel Opener, RP 66471, Induces Membrane Depolarization of Rat Liver Mitochondria

1995 • 56 citations

The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.

1987 • 50 citations

The Role of Mitochondrial Potassium Fluxes in Controlling the Protonmotive Force in Energized Mitochondria

1995 • 49 citations

ATP sensitive K+ conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide

1992 • 48 citations

Potassium channel openers induce mitochondrial matrix volume changes via activation of ATP-sensitive K+ channel.

1993 • 45 citations

Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells.

1994 • 43 citations

Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit

1992 • 40 citations

New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic beta-cell.

1994 • 39 citations

ATP-regulated K+ channel in mitochondria: Pharmacology and function

1996 • 34 citations

Evidence for three different electrophoretic pathways in yeast mitochondria: Ion specificity and inhibitor sensitivity

1993 • 33 citations

NEW PERSPECTIVES ON THE ACTIONS OF SULPHONYLUREAS AND HYPERGLYCEMIC SULFONAMIDES ON THE PANCREATIC B-CELL

1994 • 32 citations

Extrapancreatic effects of sulfonylurea drugs

1995 • 27 citations

Glibenclamide inhibits mitochondrial K+ and Na+ uniports induced by magnesium depletion

1996 • 26 citations

Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes

1991 • 24 citations

Demonstration of glibenclamide-sensitive K+ fluxes in rat liver mitochondria.

1993 • 21 citations

TMB-8 (8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenzoate) inhibits the ATP-sensitive K+ channel

1992 • 12 citations

ATP-sensitive potassium transport by pancreatic secretory granule membrane

1993 • 9 citations

Glibenclamide stimulates growth of human chondrocytes by IGF I dependent mechanisms

2009 • 9 citations

Guanidine derivative U-37883A, inhibits mitochondrial K+ uniport.

1995 • 8 citations

Effects of inhibitors and activators of ATP-regulated K+ channel on mitochondrial potassium uniport.

1996 • 7 citations

Glyburide increases the secretion, tissue uptake, and action of insulin in conscious normal dogs

1996 • 4 citations

Increase in insulin binding and inhibition of the decrease in the phospholipid content of human term placental homogenates in culture by the sulfonylurea glipizide

1993 • 3 citations