From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes

1992 • 370 citations

Characterization of Cytosolic Calcium Oscillations Induced by Phenylephrine and Vasopressin in Single Fura-2-loaded Hepatocytes

1989 • 369 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1997 • 336 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes

1997 • 254 citations

Intracellular Ca2+ Signals Activate Apoptosis in Thymocytes: Studies Using the Ca2+-ATPase Inhibitor Thapsigargin

1994 • 253 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

The role of creatine kinase in inhibition of mitochondrial permeability transition

1997 • 240 citations

Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

1996 • 234 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

Membrane Bioenergetics

1988 • 227 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

Coordination of Ca2+ Signaling by Intercellular Propagation of Ca2+ Waves in the Intact Liver

1995 • 220 citations

Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes.

1990 • 220 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

1993 • 198 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

1995 • 187 citations

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1997 • 179 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 172 citations

Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons

1996 • 169 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 166 citations

Correspondence

1996 • 164 citations

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1996 • 163 citations

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca²⁺ and Oxidant Stress

1996 • 163 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

Glutamate-induced intracellular acidification of cultured hippocampal neurons demonstrates altered energy metabolism resulting from Ca2+ loads

1994 • 152 citations

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1991 • 149 citations

Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

1994 • 149 citations

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

1995 • 118 citations

Tim23, a Protein Import Component of the Mitochondrial Inner Membrane, Is Required for Normal Activity of the Multiple Conductance Channel, MCC

1997 • 113 citations

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

1996 • 105 citations

Bcl-2 inhibits hydrogen peroxide-induced ER Ca2+ pool depletion.

1996 • 100 citations

Role of the Mitochondrial Permeability Transition in Salicylate Toxicity to Cultured Rat Hepatocytes: Implications for the Pathogenesis of Reye's Syndrome

1997 • 95 citations

Cyclosporin a protects hepatocytes against prooxidant-induced cell killing

1992 • 94 citations

Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

1990 • 88 citations

Calcium modulation of mitochondrial inner membrane channel activity

1991 • 87 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

1996 • 79 citations

Cyclosporin A Rescues Thymocytes from Apoptosis Induced by Very Low Concentrations of Thapsigargin: Effects on Mitochondrial Function

1996 • 72 citations

A model of mitochondrial Ca2+-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria

1998 • 66 citations

Targeting Peptides Transiently Block a Mitochondrial Channel

1995 • 61 citations

Inositol trisphosphate receptor mediated spatiotemporal calcium signalling

1995 • 59 citations

Bcl-2 acts subsequent to and independent of Ca2+ fluxes to inhibit apoptosis in thapsigargin- and glucocorticoidmtreated mouse lymphoma cells

1996 • 56 citations

Trifluoperazine and dibucaine‐induced inhibition of glutamate‐induced mitochondrial depolarization in rat cultured forebrain neurones

1997 • 51 citations

Ca2+ acting at the external side of the inner mitochondrial membrane can stimulate mitochondrial permeability transition induced by phenylarsine oxide

1997 • 51 citations

The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction

1992 • 46 citations

Mitochondria – the kraken wakes!

1998 • 45 citations

Multiple conductance levels in rat heart inner mitochondrial membranes studied by patch clamping

1992 • 44 citations

Mitochondrial Calcium in Relaxed and Tetanized Myocardium

1998 • 43 citations

The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction

1992 • 37 citations

GLUTAMATE‐INDUCED CALCIUM LOADS: EFFECTS ON ENERGY METABOLISM AND NEURONAL VIABILITY

1995 • 34 citations

Bcl-2 inhibits c-fos induction by calcium

1997 • 17 citations

Strontium excitability of the inner mitochondrial membrane: regenerative strontium-induced strontium release.

1995 • 14 citations

Cyclosporin A‐sensitive release of Ca²⁺from mitochondria in intact thymocytes

1997 • 9 citations

Comparison of the neuroprotective effects of APV and bcl-2 in glutamate-induced cell death

1997 • 7 citations

Cyclosporine inhibited calcium-mediated apoptosis of HL-60 cells.

1997 • 3 citations