Role of mitochondria in oxidative stress and ageing

Free radicals in biology and medicine

1991 • 17,840 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

The mitochondrial permeability transition

1995 • 2,412 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

1993 • 1,377 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Biochemical, physiological and medical aspects of ubiquinone function

1995 • 1,210 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

The biochemistry of programmed cell death

1995 • 997 citations

A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.

1990 • 981 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Mitochondrial role in cell aging

1980 • 919 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Activation of molecular oxygen by flavins and flavoproteins.

1994 • 785 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

1988 • 730 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Oxygen radical chemistry of polyunsaturated fatty acids

1989 • 716 citations

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

1996 • 699 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

1989 • 637 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Cardiolipins and biomembrane function

1992 • 597 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Effect of age onin vivorates of mitochondrial protein synthesis in human skeletal muscle

1996 • 552 citations

Chemical determination of free radical-induced damage to DNA

1991 • 523 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

Mitochondria and programmed cell death: back to the future

1996 • 508 citations

Oxidative stress: Free radical production in neural degeneration

1994 • 483 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Molecular Democracy: Who Shares the Controls?

1979 • 454 citations

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

1993 • 449 citations

Mitochondrial DNA and Disease

1995 • 444 citations

Untitled

1997 • 432 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

Current status of antioxidant therapy

1993 • 429 citations

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

1997 • 427 citations

The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q

1994 • 402 citations

Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees.

1991 • 398 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice

1997 • 388 citations

Redox and addition chemistry of quinoid compounds and its biological implications

1989 • 388 citations

Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell

1996 • 376 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Antioxidants and disease prevention

1994 • 369 citations

The Biosynthesis and Metabolism of Prostaglandins

1979 • 366 citations

Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage

1991 • 363 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

1990 • 358 citations

Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

1988 • 354 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1994 • 346 citations

The Kinetics of the Redox Reactions of Ubiquinone Related to the Electron‐Transport Activity in the Respiratory Chain

1973 • 338 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

The Reversible Removal of Cytochrome c from Mitochondria

1960 • 323 citations

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1994 • 316 citations

Free radicals in aging

1988 • 314 citations

Genetic and functional changes in mitochondria associated with aging

1997 • 311 citations

Distribution and redox state of ubiquinones in rat and human tissues

1992 • 310 citations

The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems.

1996 • 306 citations

Mitochondrial Encephalomyopathies

1993 • 297 citations

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1992 • 284 citations

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

1995 • 279 citations

Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

1990 • 259 citations

Functional binding of cardiolipin to cytochromec oxidase

1993 • 256 citations

Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster

1995 • 239 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes

1996 • 231 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

The mitochondrial site of superoxide formation

1986 • 208 citations

Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

1997 • 206 citations

Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase

1977 • 206 citations

Threshold Effects and Control of Oxidative Phosphorylation in Nonsynaptic Rat Brain Mitochondria

1996 • 204 citations

Arrangement of proteins in the mitochondrial inner membrane

1982 • 204 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Synthesis and processing of the precursor for human mangano-superoxide dismutase

1989 • 199 citations

New concepts on the role of ubiquinone in the mitochondrial respiratory chain

1981 • 194 citations

Reduced transcription of mitochondrial DNA in the senescent rat

1990 • 191 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

DNA oxidative damage and life expectancy in houseflies.

1994 • 188 citations

Mitochondrial Free Radical Signal in Ceramide‐Dependent Apoptosis: A Putative Mechanism for Neuronal Death in Parkinson's Disease

1997 • 186 citations

Bioenergetics in aging

1983 • 180 citations

Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

1993 • 175 citations

Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

1997 • 174 citations

The expanding clinical spectrum of mitochondrial diseases

1993 • 165 citations

Electron transfer properties of NADH: Ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON)

1991 • 165 citations

Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc₁ site of the mitochondrial respiratory chain

1983 • 164 citations

Modulation of Membrane Phospholipid Fatty Acid Composition by Age and Food Restriction

1993 • 164 citations

A novel heteroplasmic tRNAleu(CUN) mtDNA point mutation in a sporadic patient with mitochondrial encephalomyopathy segregates rapidly in skeletal muscle and suggests an approach to therapy

1996 • 162 citations

Age‐dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin

1997 • 156 citations

Steady-State Kinetics of the Reduction of Coenzyme Q Analogs by Complex I (NADH:Ubiquinone Oxidoreductase) in Bovine Heart Mitochondria and Submitochondrial Particles

1996 • 156 citations

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases

1995 • 156 citations

Generation of oxy radicals in biosystems

1989 • 151 citations

Mitochondrial complex I defects in aging.

1997 • 143 citations

The Mitochondrial DNA Mutation at 8993 Associated with NARP Slows the Rate of ATP Synthesis in Isolated Lymphoblast Mitochondria

1993 • 143 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles

1997 • 141 citations

Age Changes in Size and Number of Mitochondria of Human Hepatic Cells

1968 • 139 citations

Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria

1993 • 138 citations

[Free radicals and aging].

1990 • 136 citations

Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis.

1990 • 135 citations

Occurrence of a Particular Base Substitution (3243 A to G) in Mitochondrial DNA of Tissues of Ageing Humans

1993 • 134 citations

Untitled

1997 • 131 citations

Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.

1985 • 131 citations

Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy

1994 • 126 citations

Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E

1991 • 125 citations

Cyanide‐induced parkinsonism

1989 • 122 citations

Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.

1994 • 116 citations

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

1996 • 116 citations

Age-associated damage in mitochondrial DNA in human hearts

1993 • 114 citations

Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial particles

1995 • 111 citations

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunohistochemical study

1992 • 111 citations

The effect of aging and acetyl-l-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria

1992 • 111 citations

The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles.

1992 • 109 citations

How Diet Influences the Aging Process of the Rat

1994 • 107 citations

Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

1992 • 102 citations

Superoxide generation by the respiratory chain of tumor mitochondria

1987 • 100 citations

Oxygen Stress Induces an Apoptotic Cell Death Associated with Fragmentation of Mitochondrial Genome

1995 • 98 citations

Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients

1993 • 98 citations

The Interaction of Q Analogs, Particularly Hydroxydecyl Benzoquinone (Idebenone), with the Respiratory Complexes of Heart Mitochondria

1996 • 97 citations

Mitochondrial encephalomyopathies: Clinical and molecular analysis

1994 • 94 citations

Concentrations of vitamin E in various neuroanatomical regions and subcellular fractions, and the uptake of vitamin e by specific areas, of rat brain

1984 • 92 citations

Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging.

1996 • 92 citations

Aging-dependent Functional Alterations of Mitochondrial DNA (mtDNA) from Human Fibroblasts Transferred into mtDNA-less Cells

1996 • 90 citations

Mitochondrial dysfunction in movement disorders

1994 • 90 citations

Cardiolipin-dependent decrease of cytochrome c oxidase activity in heart mitochondria from hypothyroid rats

1997 • 89 citations

Changes in mitochondrial lipids of rat kidney during ischemia

1980 • 89 citations

Biosynthesis of mitochondrial manganese superoxide dismutase in saccharomyces cerevisiae. Precursor form of mitochondrial superoxide dismutase made in the cytoplasm.

1982 • 88 citations

Major changes in complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:coenzyme Q reductase

1995 • 88 citations

The specificity of mitochondrial complex I for ubiquinones

1996 • 87 citations

The mechanism of proton and electron transport in mitochondrial complex I

1994 • 78 citations

Free radicals, lipoproteins and cardiovascular dysfunction

1992 • 75 citations

Mitochondrial dysfunction in neurodegeneration.

1997 • 68 citations

Application of inhibitor titrations for the detection of oxidative phosphorylation defects in saponin-skinned muscle fibers of patients with mitochondrial diseases

1997 • 61 citations

The universality of bioenergetic disease: The role of mitochondrial mutation and the putative inter-relationship between mitochondria and plasma membrane NADH oxidoreductase

1994 • 60 citations

Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non‐synaptic mitochondria of aged rats

1997 • 60 citations

Post-ischemic apoptotic death of rat neonatal cardiomyocytes.

1995 • 58 citations

The inactivation of mitochondrial F1 ATPase by H2O2 is mediated by iron ions not tightly bound in the protein

1991 • 57 citations

An E.S.R. Investigation of the Reactive Intermediate Generated in the Reaction Between Fe^IIand H₂O₂in Aqueous Solution. Direct Evidence for the Formation of the Hydroxyl Radical

1992 • 57 citations

Studies on the Mechanism of Oxidative Phosphorylation

1966 • 56 citations

Inhibitor sensitivity of respiratory complex I in human platelets: A possible biomarker of ageing

1996 • 56 citations

Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates

1991 • 55 citations

The early intracellular production of a reactive oxygen intermediate mediates apoptosis in dexamethasone-treated thymocytes.

1995 • 53 citations

Fragmentation of Human Heart Mitochondrial DNA Associated with Premature Aging

1994 • 53 citations

Simulation of free radical reactions in biology and medicine: A new two-compartment kinetic model of intracellular lipid peroxidation☆

1990 • 52 citations

Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury

1985 • 51 citations

Iron chelators in medicine

1992 • 47 citations

The aleu207–>arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease

1993 • 47 citations

Varied Prevalence of Age-Associated Mitochondrial DNA Deletions in Different Species and Tissues: A Comparison between Human and Rat

1997 • 43 citations

Genotype and Phenotype of Severe Mitochondrial Cardiomyopathy: A Recipient of Heart Transplantation and the Genetic Control

1995 • 41 citations

Protective effect of exogenous coenzyme Q against damage by adriamycin in perfused rat liver.

1994 • 39 citations

Oxidative Modification of Nicotinamide Nucleotide Transhydrogenase in Submitochondrial Particles: Effect of Endogenous Ubiquinol

1996 • 39 citations

Extensive Tissue Oxygenation Associated with Mitochondrial DNA Mutations

1995 • 39 citations

Immune senescence

1994 • 38 citations

Oxidative energy failure in post-mitotic cells: a major factor in senescence.

1991 • 35 citations

PCR Analysis of platelet mtDNA: Lack of specific changes in Parkinson's disease

1993 • 33 citations

Oxygen-induced mitochondrial damage and aging

1992 • 32 citations

The rotenone-insensitive reduction of quinones and nitrocompounds by mitochondrial NADH:ubiquinone reductase

1991 • 28 citations

Delayed phytohemagglutinin-stimulated production of adenosine triphosphate by aged human lymphocytes: Possible relation to mitochondrial dysfunction

1983 • 25 citations

Pro- and anti-oxidant activities of the mitochondrial respiratory chain: factors influencing NAD(P)H-induced lipid peroxidation

1997 • 25 citations

Lack of major mitochondrial bioenergetic changes in cultured skin fibroblasts from aged individuals.

1994 • 24 citations

Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1.

1985 • 23 citations

H2O2-induced damage to beef heart mitochondria F0F1 ATP synthase complex: differential sensitivity of the F1 and F0 moieties.

1993 • 20 citations

Mitochondrial disorders: an overview.

1997 • 20 citations

The oxidation of ubiquinol by the isolated rieske iron-sulfur protein in solution

1990 • 20 citations

Changes in mitochondrial complex I activity and coenzyme Q binding site in Leber's hereditary optic neuropathy (LHON)

1997 • 18 citations

Chapter 6 NADH-ubiquinone oxidoreductase

1992 • 14 citations

What is in a name? Rules for radicals

1990 • 12 citations

Uptake and distribution of exogenous CoQ in the mitochondrial fraction of perfused rat liver

1994 • 11 citations

Deleted Work

1955 • 0 citations