Bcl-2 family proteins as ion-channels

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Formation of Bimolecular Membranes from Lipid Monolayers and a Study of Their Electrical Properties

1972 • 1,746 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Ionic channels of excitable membranes

1985 • 795 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

The crystal structure of diphtheria toxin

1992 • 663 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Six widespread bacterial clones among Escherichia coli K1 isolates

1983 • 453 citations

A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A

1991 • 416 citations

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.

1996 • 195 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Colicin E1 Binding to Membranes: Time-Resolved Studies of Spin-Labeled Mutants

1993 • 167 citations

A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1

1997 • 131 citations

A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members

1997 • 128 citations

Organization of Diphtheria Toxin T Domain in Bilayers: A Site-Directed Spin Labeling Study

1996 • 114 citations

Methods for studying colicins and their plasmids

1987 • 107 citations

The protein import machinery of mitochondria

1993 • 89 citations

Comparison of the macroscopic and single channel conductance properties of colicin E1 and its COOH-terminal tryptic peptide.

1983 • 74 citations

Insertion of diphtheria toxin into and across membranes: role of phosphoinositide asymmetry

1982 • 65 citations

Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor

1993 • 63 citations

Giga-Ohm Seals on Intracellular Membranes: A Technique for Studying Intracellular Ion Channels in Intact Cells

1997 • 48 citations

Membrane binding of the colicin E1 channel: activity requires an electrostatic interaction of intermediate magnitude

1996 • 39 citations

Intracellular Calcium Stores Are Not Required for Bcl-2-mediated Protection from Apoptosis

1996 • 36 citations

On the nature of the unfolded intermediate in the in vitro transition of the colicin E1 channel domain from the aqueous to the membrane phase

1994 • 35 citations

High-conductance pathways in mitochondrial membranes

1992 • 23 citations

[56] Use of lipid bilayer membranes to detect pore formation by toxins

1994 • 17 citations

Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells.

1996 • 16 citations

Structure-Function of the Channel-Forming Colicins

1995 • 4 citations