Physiological role of mitochondrial Ca2+ transport

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

The control of flux.

1973 • 1,381 citations

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

1974 • 1,378 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Electrophysiology of the pancreatic β-cell

1989 • 1,123 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

Cytosolic calcium oscillators

1988 • 690 citations

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

1975 • 559 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Energy-Linked Functions of Mitochondria

1963 • 462 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

Relation Between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart

1986 • 383 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

1985 • 356 citations

The release of acetylcholine from nerve endings by graded electric pulses

1967 • 356 citations

The inhibition of mitochondrial calcium transport by lanthanides and Ruthenium Red

1974 • 351 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1992 • 336 citations

Control of mitochondrial ATP synthesis in the heart

1991 • 333 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Relation between phosphate metabolites and oxygen consumption of heart in vivo

1989 • 249 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

The diabetic heart: metabolic causes for the development of a cardiomyopathy

1992 • 234 citations

Free energy change of ATP-hydrolysis: a causal factor of early hypoxic failure of the myocardium?,

1982 • 231 citations

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria

1993 • 221 citations

Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets

1991 • 216 citations

Ca2+ Oscillations Induced by Hormonal Stimulation of Individual Fura-2-loaded Hepatocytes

1989 • 195 citations

Control of metabolism: What do we have to measure?

1987 • 191 citations

The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria

1978 • 188 citations

Regulation of Citric Acid Cycle by Calcium

1989 • 187 citations

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.

1993 • 182 citations

Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.

1992 • 177 citations

The reversible Ca2+-induced permeabilization of rat liver mitochondria

1986 • 174 citations

Control of respiration and oxidative phosphorylation in isolated rat liver cells

1990 • 171 citations

Cytosolic free Ca2+ in single rat heart cells during anoxia and reoxygenation

1987 • 170 citations

Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential.

1988 • 163 citations

A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria.

1993 • 159 citations

Regulation of functional muscarinic receptor expression in tracheal smooth muscle cells

1991 • 154 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

1984 • 151 citations

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells

1993 • 147 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Respiratory control in the glucose perfused heart

1987 • 141 citations

Control of Mitochondrial Respiration in the Heart In Vivo

1990 • 134 citations

Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

1992 • 132 citations

A Kinetic Study of the Energy‐Linked Influx of Ca²⁺ into Heart Mitochondria

1976 • 131 citations

Dehydrogenase activation by Ca2+ in cells and tissues

1991 • 131 citations

Regulation of Mammalian Pyruvate and Branched-Chain α-Keto Acid Dehydrogenase Complexes by Phosphorylation — Dephosphorylation

1985 • 126 citations

Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones.

1990 • 123 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Control of mitochondrial ATP synthase in heart cells: inactive to active transitions caused by beating or positive inotropic agents

1990 • 113 citations

The effect of ruthenium red on the uptake and release of Ca2+ by mitochondria

1973 • 112 citations

³¹P‐NMR studies of respiratory regulation in the intact myocardium

1986 • 111 citations

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1988 • 110 citations

Studies on mitochondrial Ca2+-transportand matrix Ca2+ using fura-2-loaded rat heart mitochondria

1989 • 103 citations

The Regulation of Mitochondrial Calcium Transport in Heart

1985 • 102 citations

Dissociation between contractile function and oxidative metabolism in postischemic myocardium. Attenuation by ruthenium red administered during reperfusion.

1992 • 101 citations

Stimulation of K-C1 cotransport in rat red cells by a hemolytic anemia-producing metabolite of dapsone

1989 • 101 citations

Subcellular calcium and magnesium mobilization in rat liver stimulated in vivo with vasopressin and glucagon.

1987 • 98 citations

Cyclosporin A protects hepatocytes subjected to high Ca²⁺ and oxidative stress

1992 • 96 citations

Estimation of intramitochondrial pCa and pH by fura-2 and 2,7 biscarboxyethyl-5(6)-carboxyfluorescein (BCECF) fluorescence

1987 • 96 citations

Total and free myoplasmic calcium during a contraction cycle: x‐ray microanalysis in guinea‐pig ventricular myocytes.

1991 • 94 citations

Changes in mitochondrial calcium concentration during the cardiac contraction cycle

1993 • 94 citations

A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources

1981 • 91 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Mitochondrial calcium overloading in cardiomyopathic hamsters

1978 • 88 citations

Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using31P n.m.r. and ruthenium red

1989 • 84 citations

Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes

1987 • 83 citations

Intramitochondrial and extramitochondrial free calcium ion concentrations of suspensions of heart mitochondria with very low, plausibly physiological, contents of total calcium

1982 • 82 citations

Calcium and pH in Anoxic and Toxic Injury

1990 • 82 citations

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2

1987 • 82 citations

Calcium signalling in non-excitable cells: Notes on oscillations and store refilling

1989 • 78 citations

Conversion of esterified fura-2 and indo-1 to Ca2+-sensitive forms by mitochondria

1988 • 77 citations

Vasopressin and/or glucagon rapidly increases mitochondrial calcium and oxidative enzyme activities in the perfused rat liver.

1986 • 77 citations

Sodium/calcium exchange and intracellular calcium buffering in ferret myocardium: an ion‐sensitive micro‐electrode study.

1986 • 76 citations

Interactions between spermine and Mg2+ on mitochondrial Ca2+ transport.

1986 • 76 citations

THE ACCUMULATION OF DIVALENT IONS BY ISOLATED MITOCHONDRIA

1963 • 70 citations

Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets

1990 • 70 citations

The α-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+in vivo

1983 • 68 citations

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

1981 • 68 citations

Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondria

1989 • 66 citations

Evaluation of the hereditary Syrian hamster cardiomyopathy by 31P nuclear magnetic resonance spectroscopy: improvement after acute verapamil therapy.

1986 • 61 citations

Hereditary polymyopathy and cardiomyopathy in the syrian hamster. II. Development of heart necrotic changes in relation to defective mitochondrial function

1982 • 61 citations

Changes in Mitochondrial Matrix Free Calcium in Perfused Rat Hearts Subjected to Hypoxia-Reoxygenation

1993 • 61 citations

Intramitochondrial free calcium in cardiac myocytes in relation to dehydrogenase activation

1993 • 55 citations

Activation of dehydrogenase activity and cardiac respiration: a 31P-NMR study

1988 • 55 citations

Calcium and proton activities in rat cardiac mitochondria. Effect of matrix environment on behaviour of fluorescent probes

1989 • 52 citations

Energy metabolism and contractile function in rat heart during graded, isovolumic perfusion using 31P nuclear magnetic resonance spectroscopy

1987 • 52 citations

A 13C-NMR Study of Glucose Oxidation in the Intact Functioning Rat Heart Following Diabetes-induced Cardiomyopathy

1993 • 46 citations

The Ca2+ and Mg2+ dependence of Ca2+ uptake and respiratory function of porcine heart mitochondria. Probable physiological significance during the cardiac contraction-relaxation cycle.

1982 • 46 citations

Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters

1993 • 46 citations

Myocyte deenergization and intracellular free calcium dynamics

1988 • 45 citations

Effect of inotropic stimulation on mitochondrial calcium in cardiac muscle.

1992 • 45 citations

Calcium buffering in axons and axoplasm of Loligo.

1987 • 45 citations

Comparison of Ca2+, Sr2+, and Mn2+ fluxes in mitochondria of the perfused rat heart.

1980 • 45 citations

The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes

1980 • 44 citations

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca²⁺ in fura‐2‐loaded heart mitochondria

1988 • 42 citations

Cardiomyopathic and healthy acidotic hamster hearts: mitochondrial activity may regulate cardiac performance

1986 • 42 citations

[Ca2+]i transients in the cardiomyopathic hamster heart.

1991 • 38 citations

Calcium is released from the junctional sarcoplasmic reticulum during cardiac muscle contraction

1991 • 38 citations

Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria.

1992 • 33 citations

The loading of fura-2 into mitochondria in the intact perfused rat heart and its use to estimate matrix Ca2+ under various conditions

1992 • 32 citations

Subcellular calcium content in cardiomyopathic hamster hearts in vivo: an electron probe study.

1989 • 32 citations

Molecular Abnormalities in Cardiomyopathy1

2015 • 31 citations

Defects in regulation of mitochondrial ATP synthase in cardiomyocytes from spontaneously hypertensive rats

1990 • 31 citations

Regulation of cardiac mitochondrial calcium by average extramitochondrial calcium

1993 • 29 citations

Novel technique to load indo-1 free acid into single adult cardiac myocytes to assess cytosolic Ca2+

1992 • 28 citations

Energetics and the Failing Heart

1991 • 26 citations

Activation of pyruvate dehydrogenase by electrical stimulation, and low-Na+ perfusion of guinea-pig heart

1990 • 24 citations

Responses of contractile function to ruthenium red in rat heart

1988 • 24 citations

Influence of ruthenium red on rat heart subcellular calcium transport.

1989 • 22 citations

Mitochondrial dehydrogenase activity affects adaptation of cardiac oxygen consumption to demand

1993 • 21 citations

The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes

1984 • 21 citations

Calcium in the in situ mitochondria of rested and stimulated myocardium

1991 • 17 citations

Novel method to alter length and load in isolated mammalian cardiac myocytes

1994 • 13 citations